全文获取类型
收费全文 | 6354篇 |
免费 | 372篇 |
国内免费 | 36篇 |
专业分类
耳鼻咽喉 | 76篇 |
儿科学 | 156篇 |
妇产科学 | 226篇 |
基础医学 | 910篇 |
口腔科学 | 169篇 |
临床医学 | 511篇 |
内科学 | 1139篇 |
皮肤病学 | 160篇 |
神经病学 | 445篇 |
特种医学 | 333篇 |
外科学 | 881篇 |
综合类 | 116篇 |
一般理论 | 2篇 |
预防医学 | 642篇 |
眼科学 | 118篇 |
药学 | 538篇 |
中国医学 | 65篇 |
肿瘤学 | 275篇 |
出版年
2023年 | 32篇 |
2022年 | 79篇 |
2021年 | 187篇 |
2020年 | 95篇 |
2019年 | 166篇 |
2018年 | 207篇 |
2017年 | 143篇 |
2016年 | 133篇 |
2015年 | 184篇 |
2014年 | 209篇 |
2013年 | 278篇 |
2012年 | 464篇 |
2011年 | 490篇 |
2010年 | 254篇 |
2009年 | 189篇 |
2008年 | 338篇 |
2007年 | 351篇 |
2006年 | 310篇 |
2005年 | 282篇 |
2004年 | 310篇 |
2003年 | 230篇 |
2002年 | 241篇 |
2001年 | 181篇 |
2000年 | 212篇 |
1999年 | 155篇 |
1998年 | 61篇 |
1997年 | 49篇 |
1996年 | 46篇 |
1995年 | 38篇 |
1994年 | 35篇 |
1993年 | 39篇 |
1992年 | 71篇 |
1991年 | 54篇 |
1990年 | 62篇 |
1989年 | 69篇 |
1988年 | 57篇 |
1987年 | 56篇 |
1986年 | 56篇 |
1985年 | 56篇 |
1984年 | 28篇 |
1983年 | 38篇 |
1982年 | 25篇 |
1981年 | 14篇 |
1979年 | 14篇 |
1978年 | 20篇 |
1977年 | 16篇 |
1976年 | 19篇 |
1974年 | 17篇 |
1973年 | 12篇 |
1972年 | 13篇 |
排序方式: 共有6762条查询结果,搜索用时 312 毫秒
11.
D J Martin B D Schoub G B Miller J G Sim 《Suid-Afrikaanse tydskrif vir geneeskunde》1990,78(9):533-535
The diagnostic and therapeutic implications of human immunodeficiency virus (HIV) infection and tuberculosis in South Africa, where tuberculosis remains a major health problem, are reviewed. Mycobacterium tuberculosis is a high-grade pathogen and is able to establish infection early in immunodeficiency. With HIV infection showing significant entry into the heterosexual population in the RSA, an increasing number of cases with both infections can be expected to occur. The radiological appearance in combined infection is variable, ranging from a formal cavitatory picture to the more common finding of diffuse pulmonary infiltration. Intrathoracic adenopathy is a more specific sign of tuberculosis in HIV infection, since it is not associated with persistent generalised lymphadenopathy and pulmonary opportunistic infections, such as Pneumocystis carinii pneumonia. Intercurrent pneumonic infections and other pulmonary manifestations of HIV disease render the interpretation of new infiltrates on chest radiography problematical. Tuberculin skin testing remains useful in HIV infection and should be performed in all HIV-infected patients. The value of tuberculosis serology still remains questionable. Standard antituberculosis drug regimens are effective, but maintenance treatment must be continued for life and should include isoniazid and rifampicin. BCG vaccination is recommended routinely at birth in infants with HIV infection and for asymptomatic HIV-infected individuals who have not previously been immunised. 相似文献
12.
Kyung Bok Lee Jong Sig Kim Sang Tae Kwak Wonbo Sim Jong Hwan Kwak Yeong Shik Kim 《Archives of pharmacal research》1998,21(5):555-558
Chondroitin sulfates were isolated from the mud snail. For the quantitative analysis of enzymatic digestion products of isolated
chondroitin sulfates, strong anion exchange-high performance liquid chromatography (SAX-HPLC) was performed. By the action
of chondroitinase ABC, three unsaturated disaccharides 2-acetamide-2-deoxy-3-O-(β-D-gluco-4-enepyranosyluronic acid)-D-galactose (ΔDi-OS), 2-acetamide-2-deoxy-3-O-(β-D-gluco-4-enepyranosyluronic acid)-6-O-sulfo-D-galactose (ΔDi-6S) and 2-acetamide-2-deoxy-3-O-(β-D-gluco-4-enepyranosyluronic acid)-4-O-sulfo-D-galactose (ΔDi-4S) were produced from the mud snail chondroitin sulfates. The analysis showed that relative proportion
of ΔDi-OS/ΔDi-6S/ΔDi-4S was 58.7/3.1/38.2. The immunomodulating activity of chondroitin sulfate was examined by cell proliferation
assay and these results suggest that it might be a immunosuppressant. 相似文献
13.
14.
Fibular reconstruction for giant cell tumor of the distal radius 总被引:2,自引:0,他引:2
R D Lackman D J McDonald R D Beckenbaugh F H Sim 《Clinical orthopaedics and related research》1987,(218):232-238
The management of giant cell tumors involving the distal radius has always been a difficult problem. After resection to eradicate a primary or recurrent lesion, transplantation of a nonvascularized fibular autograft was used in 12 patients. Of these patients, ten had good to excellent functional results. The procedure can restore a functionally useful wrist. 相似文献
15.
Carlos Cotrim Otília Sim?es M J Loureiro Pedro Cordeiro Rita Miranda Cecília Silva Teresa Avillez Manuel Carrageta 《Revista portuguesa de cardiologia》2006,25(5):529-533
We describe the case of a pregnant woman with idiopathic pulmonary arterial hypertension, a responder in right heart catheterization, followed since the first trimester in outpatient consultations, admitted to hospital at 23 weeks gestation. She was treated with inhaled iloprost until delivery (at 34 weeks gestation) and continuous infusion of iloprost throughout the perioperative period and following days. This line of therapy has proved efficacious in previous cases. The authors present echocardiographic images that document acute changes in ventricular synchrony during inhalation of iloprost. 相似文献
16.
The protein phosphatase inhibitor okadaic acid was used to investigate the protein phosphatases involved in the endogenous dephosphorylation of proteins in intact synaptosomes. Despite the fact that the calcium-dependent protein phosphatase (calcineurin) is most concentrated in synaptosomes and accounts for approximately 0.3% of synaptoplasmic protein, the majority of the dephosphorylation activity under both basal and depolarisation conditions is due to protein phosphatase type 1 (PP1) and/or protein phosphatase type 2A (PP2A). Nevertheless our results do suggest that calcineurin is active in synaptosomes and has 2 effects: a rapid, direct dephosphorylation of a limited range of substrates and an indirect activation of PP1 presumably by dephosphorylation of protein phosphatase 1 inhibitor-1. 相似文献
17.
18.
19.
Quality of life in adult survivors of lung,colon and prostate cancer 总被引:22,自引:0,他引:22
C. A. C. Schag P. A. Ganz D. S. Wing M. -S. Sim J. J. Lee 《Quality of life research》1994,3(2):127-141
In a cross-sectional study design, a disease free sample of 57 lung, 117 colon, and 104 prostate cancer survivors who represented short, intermediate and long-term survivors completed a detailed assessment of quality of life (QOL) and rehabilitation needs using the CAncer Rehabilitation Evaluation System (CARES). Demographic and medical data, social support, and a global QOL rating were also assessed. Lung cancer patients showed no differences in QOL with respect to their period of survival. QOL improved for survivors of colon cancer as they lived for longer periods, but declined with time for survivors of prostate cancer. The best predictor of QOL for all groups was KPS, although other variables such as type of hospital, gender, and work status were predictive for survivors of colon cancer. For survivors of prostate cancer comorbidity with other medical illnesses, time since diagnosis and comorbidity due to psychiatric difficulties were predictive of QOL. All groups had significant rehabilitation problems in the domains of physical, psychosocial, sexual, medical interaction, and marital relationships. Lung cancer survivors had more problems than the other cancer survivors. We conclude that patients who survive cancer do not return to a state of normal health. They demonstrate a variety of difficulties with which they must cope as they continue to survive. Greater efforts need to be made early in diagnosis and treatment to understand rehabilitation problems and target interventions in the hope of reducing later sequelae.Currently in private practice, Glendale, CaliforniaC. A. C. Schag was supported in part by Veterans Administration Health Research and Development Grant 83-002 and in part by Cares Consultants, 2210 Wilshire Blvd., Suite 359, Santa Monica, CA 90403.Address requests for Information about CARES to: CARES Consultants, 2210 Wilshire Blvd., Suite 359, Santa Monica, CA 90403, USA. Tel: (+1) 310-450-7410; Fax: (+1) 310-399-0016 相似文献
20.
C1: molecular interactions with activating systems. 总被引:1,自引:0,他引:1
The molecular events controlling complement activation have been gradually unravelled over the past three decades, stimulated by improved isolation procedures and a better understanding of the roles of individual proteins. In this review, Bob Sim and Ken Reid examine the interactions between C1q and its numerous ligands in the initiation of the classical pathway cascade. 相似文献