Mediastinal lymph node clearance after docetaxel-cisplatin neoadjuvant chemotherapy is prognostic of survival in patients with stage IIIA pN2 non-small-cell lung cancer: a multicenter phase II trial.

PURPOSE: A multicenter, phase II trial investigated the efficacy and toxicity of neoadjuvant docetaxel-cisplatin in locally advanced non-small-cell lung cancer (NSCLC) and examined prognostic factors for patients not benefiting from surgery. PATIENTS AND METHODS: Ninety patients with previously untreated, potentially operable stage IIIA (mediastinoscopically pN2) NSCLC received three cycles of docetaxel 85 mg/m2 day 1 plus cisplatin 40 mg/m2 days 1 and 2, with subsequent surgical resection. RESULTS: Administered dose-intensities were docetaxel 85 mg/m2/3 weeks (range, 53 to 96) and cisplatin 95 mg/m2/3 weeks (range, 0 to 104). The 265 cycles were well tolerated, and the overall response rate was 66% (95% confidence interval [CI], 55% to 75%). Seventy-five patients underwent tumor resection with positive resection margin and involvement of the uppermost mediastinal lymph node in 16% and 35% of patients, respectively (perioperative mortality, 3%; morbidity, 17%). Pathologic complete response occurred in 19% of patients with tumor resection. In patients with tumor resection, downstaging to N0-1 at surgery was prognostic and significantly prolonged event-free survival (EFS) and overall survival (OS; P =.0001). At median follow-up of 32 months, the median EFS and OS were 14.8 months (range, 2.4 to 53.4) and 33 months (range, 2.4 to 53.4), respectively. Local relapse occurred in 27% of patients with tumor resection, with distant metastases in 37%. Multivariate analyses identified mediastinal clearance (hazard ratio, 0.22; P =.0003) and complete resection (hazard ratio, 0.26; P =.0006) as strongly prognostic for increased survival. CONCLUSION: Neoadjuvant docetaxel-cisplatin is effective and tolerable in stage IIIA pN2 NSCLC. Resection is recommended only for patients with mediastinal downstaging after chemotherapy.     

爱普列特抑制体外培养的大鼠前列腺上皮细胞生长(英文)

目的:研究爱普列特对体外培养前列腺上皮细胞表皮生长因子受体和胰岛素样生长因子-Ⅰ受体表达的影响,探讨其抗前列腺增生的分子机制。方法:MTT法检测爱普列特对外源性表皮生长因子(epider-mal growth factof,EGF),胰岛素样生长因Ⅰ(insulin-like growth factor Ⅰ,IGF-Ⅰ)诱导的大鼠前列腺上皮细胞增殖的作用,逆转录PCR及流式细胞术定量检测体外培养前列腺上皮细胞EGFR和IGF-ⅠR mRNA及蛋白表达。结果:爱普列特180nmol/L和360nmol/L可以明显抑制IGF-Ⅰ5,25μg/L诱导的细胞增殖;爱普列特360 nmol/L可以抑制EGF25μg/L诱导的细胞增殖;爱普列特360nmol/L可以明显下调EGFR、IGF-ⅠR mRNA的表达,而爱普列特180nmol/L则没有明显作用;爱普列特180nmol/L和360nmol/L均可以明显下调EGFR和IGF-ⅠR蛋白的表达。结论:爱普列特抗前列腺增生的分子机制与纠正增生时异常表达的生长因子有关。     

氯霉素滴眼液的吸附伏安法测定

在０．０１ｍｏｌ／ＬＮａＯＨ溶液中，氯霉素具有灵敏的吸附还原波，峰电位在－０．５３Ｖ（ｖｓ．ＳＣＥ）。浓度在５．０×１０－３～２．５×１０－１μｇ／ｍｌ范围内，峰电流与浓度呈线性关系。可用吸附伏安法测定滴眼液中氯霉素含量，结果满意。     

Homonymous central quadrantanopia caused by an extrastriate (v2/v3) infarction: a case report

A 66-year-old Taiwanese aboriginal male had complained of right-side blurred vision for 2 months, especially when reading. He had a 10-year history of hypertension and cardiovascular disease. His best-corrected visual acuity was 20/25 in each eye. Ophthalmoscopy revealed asymmetrical cupping, but a normal disc. Humphrey perimetry showed an upper homonymous paracentral quadrantanopic defect. Brain magnetic resonance imaging showed an infarction in the left lower calcarine area over the extrastriate (V2/V3) cortical area and a narrowing of the left middle and posterior cerebral arteries due to severe arteriosclerosis.     

EITOP方案治疗复发和难治性非霍奇金淋巴瘤疗效分析

目的:探讨用足叶乙甙(VP-16,E)、异环磷酰胺(Ifosfamide,I)、吡柔比星(Pirarubicin,T)、长春新碱(VCR,O)、泼尼松(Prednisone,P)组成的EITOP方案治疗复发或难治非霍奇金淋巴瘤的疗效和毒性。方法:42例患者予EITOP方案治疗,异环磷酰胺1.2g.(m2)-1.d-1静脉滴注,d1～d5,吡柔比星30mg.(m2)-1.d-1静脉注射,d1～d3,长春新碱1.4mg.(m2)-1.d-1,静脉注射,d1,泼尼松40mg.(m2)-1.d-1口服,d1～d7,平均每3周为1周期,全组患者接受3个～8个周期治疗,平均4个周期。结果:42例患者接受EITOP方案化疗,完全缓解22例,部分缓解10例,总有效率76.19%,中位生存期为42个月,毒副作用主要为骨髓抑制。结论:EITOP方案是治疗复发或难治非霍奇金淋巴瘤的有效方案,毒性反应可耐受。     

Predictors of community women's osteoporosis prevention intention--a pilot study

The main purpose of this pilot study was to identify the predictors of community women's osteoporosis prevention intention. The osteoporosis assessment scales were self-developed and contained 5 scales: a demographics scale, a health status scale, an osteoporosis health belief scale (OHBS), a knowledge scale, and a prevention intention scale. The content validity of the five scales ranged from.90 to 1.00. Test-retest was used to examine the reliability of the demographic characteristics scale and the health status scale, which ranged from.9 to 1.0. Meanwhile, the reliability coefficients of the OHBS comprising perceived susceptibility, perceived seriousness, perceived benefit, and perceived barrier were .75, .90, .80, and .72. In this pilot study, the coefficient of KR-20 for osteoporosis knowledge was .88. The value of Cronbach 's Coefficient Alpha for prevention intention was .85. The results of this research were : (1) The averaged scores of the OHBS comprising perceived susceptibility, perceived seriousness, perceived benefit, and perceived barrier were 2.8 (SD = 0.5), 2.2 (SD = 0.7), 1.9 (SD = 0.4), and 2.9 (SD = 0.7). Meanwhile, the averaged score for women's knowledge on osteoporosis was 10.0 (SD = 2.8). The averaged score for women's intentions for the prevention of osteoporosis was 2.5 (SD = 0.6). (2) There were some significant correlations between OHBS and demographics, health status, knowledge, and prevention intention. (3) Knowledge was positively correlated with perceived barriers, prevention intention, age, self-rated score for health, breast feeding time, and amount of calcium intake. (4) Prevention intention was positively correlated with knowledge, number of children, age of fracture, and hormone replacement therapy. (5) The major factors influencing intention for community women were, in order, knowledge, educational level (high school graduate), number of children (n = 2), self-rated health score, experience of bone density examination (yes), hormone replacement therapy (yes), and kyphosis (yes). These seven items accounted for 45.8% of the variation in intention. The results of this pilot study can help community health professionals evaluate, implement and improve community women's health beliefs regarding prevention of osteoporosis.     

非致炎浓度的福尔马林激活小鼠皮肤辣椒素受体

目的：探索非致炎浓度的福尔马林对小鼠皮肤辣椒素受体（vanilloid receptor type 1，VR1）的激活作用。方法：选用KM小鼠随机分为3组：福尔马林（formalin，FM）组、辣椒素（capsaicin，CAP）组和Capsazepine（CPZ）组。采用注射后5min内小鼠舔舐注射脚掌的时间作为评价疼痛反应的指标，对各组小鼠的痛反应进行观测。结果：0．025％FM和200μmol／LCAP是理想的实验浓度，既能引起显著疼痛反应，又不引起炎性损伤的致痛浓度，适于研究受体拮抗剂的抗疼痛作用；1μmol／LCPZ分别与200μmol／LCAP和0．025％FM共注射能有效的拮抗CAP和FM引起的疼痛反应。结论：非致炎浓度FM所致的疼痛反应在外周可能由VR1介导。     

Possible mechanisms mediating apoptosis of bronchial epithelial cells in chronic obstructive pulmonary disease – A next-generation sequencing approach

Purpose

Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory airway disease characterized by persistent airflow limitation. Apoptosis of pulmonary structural cells contributes to pulmonary destruction and dysfunction. This study aimed to explore the possible mechanisms underlying decreased cell proliferation and increased apoptosis of bronchial epithelial cells of COPD.

An accelerometer-based handheld system to reduce breaks in performance of young adults with cognitive impairments

This study assessed the possibility of training two individuals with cognitive impairments using a system that reduced breaks in performance. This study was carried out according to an ABAB sequence in which A represented the baseline and B represented intervention phases. Data showed that the two participants significantly increased their target response, thus reducing breaks and improving vocational job performance during the intervention phases. Practical and developmental implications of the findings are discussed.