全文获取类型
收费全文 | 22766篇 |
免费 | 1518篇 |
国内免费 | 226篇 |
专业分类
耳鼻咽喉 | 381篇 |
儿科学 | 327篇 |
妇产科学 | 297篇 |
基础医学 | 3904篇 |
口腔科学 | 396篇 |
临床医学 | 1884篇 |
内科学 | 4498篇 |
皮肤病学 | 751篇 |
神经病学 | 1953篇 |
特种医学 | 1198篇 |
外科学 | 3082篇 |
综合类 | 94篇 |
一般理论 | 4篇 |
预防医学 | 855篇 |
眼科学 | 496篇 |
药学 | 2136篇 |
中国医学 | 296篇 |
肿瘤学 | 1958篇 |
出版年
2024年 | 16篇 |
2023年 | 201篇 |
2022年 | 508篇 |
2021年 | 828篇 |
2020年 | 425篇 |
2019年 | 596篇 |
2018年 | 695篇 |
2017年 | 528篇 |
2016年 | 794篇 |
2015年 | 1015篇 |
2014年 | 1160篇 |
2013年 | 1374篇 |
2012年 | 2029篇 |
2011年 | 1949篇 |
2010年 | 1129篇 |
2009年 | 921篇 |
2008年 | 1413篇 |
2007年 | 1310篇 |
2006年 | 1215篇 |
2005年 | 1095篇 |
2004年 | 955篇 |
2003年 | 827篇 |
2002年 | 725篇 |
2001年 | 429篇 |
2000年 | 401篇 |
1999年 | 339篇 |
1998年 | 170篇 |
1997年 | 127篇 |
1996年 | 116篇 |
1995年 | 101篇 |
1994年 | 80篇 |
1993年 | 69篇 |
1992年 | 100篇 |
1991年 | 103篇 |
1990年 | 81篇 |
1989年 | 75篇 |
1988年 | 76篇 |
1987年 | 67篇 |
1986年 | 51篇 |
1985年 | 52篇 |
1984年 | 37篇 |
1983年 | 41篇 |
1982年 | 27篇 |
1981年 | 20篇 |
1980年 | 24篇 |
1979年 | 38篇 |
1978年 | 19篇 |
1976年 | 18篇 |
1972年 | 15篇 |
1969年 | 15篇 |
排序方式: 共有10000条查询结果,搜索用时 31 毫秒
991.
992.
Min-Ho Shin Jin-Su Choi Jung-Ae Rhee Young-Hoon Lee Hae-Sung Nam Seul-Ki Jeong Kyeong-Soo Park Hye-Yeon Kim So-Yeon Ryu Seong-Woo Choi Hee Nam Kim Hye-Rim Song Jane A. Cauley Sun-Seog Kweon 《Atherosclerosis》2014
Objective
We evaluated the association between APOE polymorphism and carotid atherosclerosis in two large independent cohorts from South Korea.Methods
The datasets were from the Dong-gu Study (N = 9056) and the Namwon Study (N = 10,158). Carotid ultrasonography was performed to measure carotid intima-media thickness (IMT) and the presence of carotid plaques. The APOE polymorphism was determined by PCR-RFLP. We performed combined and separate analyses for the two datasets.Results
In the combined analysis, individuals with E2E2 or E2E3 genotype had a lower common carotid IMT compared with individuals with E3E3 genotype (0.684 mm vs. 0.736 mm, p = 0.007; 0.718 mm vs. 0.736 mm, p < 0.001, respectively). This association was very slightly attenuated but remained statistically significant after adjustment for blood lipids (0.690 mm vs. 0.736 mm, p = 0.033; 0.725 mm vs. 0.736 mm, p = 0.005, respectively). Compared with individuals with E3E3 genotype, individuals with E2E3 genotype had lower risk for carotid plaque (odds ratio (OR) = 0.83, 95% confidence interval (CI) = 0.75–0.93), while individuals with E3E4 genotype had a higher risk for carotid plaque (OR = 1.09, 95% CI = 1.00–1.20). After adjustment for blood lipids, ORs of E2E3 genotype for carotid plaque was slightly attenuated but remained significant (OR = 0.87 95% CI = 0.78–0.97), while OR of E3E4 genotype were slightly attenuated and not significant (OR = 1.08, 95% CI, 0.99–1.18).Conclusions
We found that APOE polymorphism is associated with carotid atherosclerosis and this association was partly mediated through blood lipid. Our results suggest that APOE polymorphism may influence atherosclerosis through non-lipid pathways. 相似文献993.
Won-Suk Lee Hye-Youn Kim Jae Yeon Seok Ho Hee Jang Yeon Ho Park So-Young Kim Dong Bok Shin Suntaek Hong 《Medicine》2014,93(28)
Recent evidence suggests that patient derived xenograft (PDX) models can maintain certain pathological and molecular features of the original disease. However, these characterizations are limited to immunohistochemistry or by tissue microarray analysis. We conducted a high-throughput sequencing of primary colon tumor and PDX has not been reported yet.Fresh primary colon cancer tissues that originate from surgery were implanted into the subcutaneous space of 6- to 8-week-old female BALB/c nu/nu or NOD/SCID mice and serially passaged in vivo. Ion AmpliSeq Cancer Hotspot Panel v2 (Ion Torrent) was used to detect frequent somatic mutations and similarity of molecular characteristics between the 10 patient tumors and matched PDX.Histologic and immunohistochemical analyses revealed a high degree of pathologic similarity including histologic architecture and expression of CEA, CK7, and CD20 between the patient and xenograft tumors. In 80% cases, all of the somatic mutations detected in primary tumor were concordantly detected in PDX models. However, 2 PDX models showed gained mutations such as PIK3CA or FBWX7 mutation.Ten patient-derived advanced colon cancer xenograft models were established. These models maintained the key characteristic features of the original tumors, suggesting useful tool for preclinical personalized medicine platform. 相似文献
994.
Jong Bong Lee Tae Hwan Kim Wanshan Feng Hyeon Gwan Choi Atheer Zgair Soyoung Shin Sun Dong Yoo Pavel Gershkovich Beom Soo Shin 《Journal of pharmaceutical sciences》2019,108(2):1047-1052
For performance assessment of the lipid-based drug delivery systems (LBDDSs), in vitro lipolysis is commonly applied because traditional dissolution tests do not reflect the complicated in vivo micellar formation and solubilization processes. Much of previous research on in vitro lipolysis has mostly focused on rank-ordering formulations for their predicted performances. In this study, we have incorporated in vitro lipolysis with microsomal stability to quantitatively predict the oral bioavailability of a lipophilic antineoplastic drug bexarotene (BEX) administered in LBDDS. Two types of LBDDS were applied: lipid solution and lipid suspension. The predicted oral bioavailability values of BEX from linking in vitro lipolysis with microsomal stability for lipid solution and lipid suspension were 34.2 ± 1.6% and 36.2 ± 2.6%, respectively, whereas the in vivo oral bioavailability of BEX was tested as 31.5 ± 13.4% and 31.4 ± 5.2%, respectively. The predicted oral bioavailability corresponded well with the oral bioavailability for both formulations, demonstrating that the combination of in vitro lipolysis and microsomal stability can quantitatively predict oral bioavailability of BEX. In vivo intestinal lymphatic uptake was also assessed for the formulations and resulted in <1% of the dose, which confirmed that liver microsomal stability was necessary for correct prediction of the bioavailability. 相似文献
995.
996.
Asif Jan Jisu Shin Junsung Ahn Sungeun Yang Kyung Joong Yoon Ji-Won Son Hyoungchul Kim Jong-Ho Lee Ho-Il Ji 《RSC advances》2019,9(46):27002
Low temperature CO oxidation reaction is known to be facilitated over platinum supported on a reducible cerium oxide. Pt species act as binding sites for reactant CO molecules, and oxygen vacancies on surface of cerium oxide atomically activate the reactant O2 molecules. However, the impacts of size of Pt species and concentration of oxygen vacancy at the surface of cerium oxide on the CO oxidation reaction have not been clearly distinguished, thereby various diverse approaches have been suggested to date. Here using the co-precipitation method we have prepared pure ceria support and infiltrated it with Pt solution to obtain 0.5 atomic% Pt supported on cerium oxide catalyst, and then systematically varied the size of Pt from single atom to ∼1.7 nm sized nanoparticles and oxygen vacancy concentration at surface of cerium oxide by controlling the heat-treatment conditions, which are temperature and oxygen partial pressure. It is found that Pt nanoparticles in range of 1–1.7 nm achieve 100% of CO oxidation reaction at ∼100 °C lower temperature compared to Pt single atom owing to the facile adsorption of CO but weaker binding strength between Pt and CO molecules, and the oxygen vacancy in the vicinity of Pt accelerates CO oxidation below 150 °C. Based on this understanding, we show that a simple hydrogen reduction at 550 °C for the single atom Pt supported on CeO2 catalyst induces the formation of highly dispersed Pt nanoparticles with size of 1.7 ± 0.2 nm and the higher concentration of surface oxygen vacancies simultaneously, enabling 100% conversion from CO to CO2 at 200 °C as well as 16% conversion even at 150 °C owing to the synergistic effects of Pt nanoparticles and oxygen vacancies.Understanding on effects of Pt size and oxygen vacancy at CeO2 surface in Pt/CeO2 catalyst for CO oxidation reaction enables to boost catalytic activity. 相似文献
997.
998.
999.
1000.
Jo Jae-Cheol Kim Seok Jin Lee Ho Sup Eom Hyeon-Seok Lee Soon Il Park Yong Lee Jeong-Ok Lee Yoojin Yhim Ho-Young Yang Deok-Hwan Byun Ja Min Kang Hye Jin Kim Hyo Jung Shin Ho-Jin Yoo Kwai Han Suh Cheolwon 《Annals of hematology》2020,99(2):223-228
Annals of Hematology - Limited-stage (Ann Arbor stage I or II) mantle cell lymphoma (MCL) is an extremely rare disease. Thus, there is little data on the clinical features and treatment outcomes of... 相似文献