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Kristo Nuutila PhD Mansher Singh MD Carla Kruse MD Justin Philip BEng Edward J. Caterson MD PhD Elof Eriksson MD PhD 《Wound repair and regeneration》2016,24(6):1097-1102
Standardized and reproducible animal models are crucial in medical research. Rodents are commonly used in wound healing studies since, they are easily available, affordable and simple to handle and house. However, the most significant limitation of rodent models is that the wounds heal by contraction while in humans the primary mechanisms of healing are reepithelialization and granulation tissue formation. The robust contraction results in faster wound closure that complicates the reproducibility of rodent studies in clinical trials. We have developed a titanium wound chamber for rodent wound healing research. The chamber is engineered from two pieces of titanium and is placed transcutaneously on the dorsum of a rodent. The chamber inhibits wound contraction and provides a means for controlled monitoring and sampling of the wound environment in vivo with minimal foreign body reaction. This technical report introduces two modalities utilizing the titanium chambers in rats: (1) Wound in a skin island model and, (2) Wound without skin model. Here, we demonstrate in rats how the “wound in a skin island model” slows down wound contraction and how the “wound without skin” model completely prevents the closure. The titanium wound chamber provides a reproducible standardized models for wound healing research in rodents. 相似文献
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Bikram Kesharee Mohanty Sudip Dutta Baruah Ashutosh Marwah Vishal Kamlaprasad Singh Rajesh Sharma 《Indian Journal of Thoracic and Cardiovascular Surgery》2016,32(2):133-135
Successful single stage repair of complete atrioventricular septal defect and cricotracheal stenosis in an 8-month-old baby with Trisomy 21 is described. The case is notable for rarity of cricoid stenosis being managed together with the long segment tracheal narrowing using the technique of slide cricotracheoplasty. 相似文献
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Isolation of a lytic bacteriophage against virulent Aeromonas hydrophila from an organized equine farm 下载免费PDF全文
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S.P. Singh PhD Ola Ibrahim MSc Hugh J. Byrne PhD Jopi W. Mikkonen MSc Arto P. Koistinen PhD Arja M. Kullaa PhD Fiona M. Lyng PhD 《Head & neck》2016,38(Z1):E2403-E2411
Optical diagnosis techniques offer several advantages over traditional approaches, including objectivity, speed, and cost, and these label‐free, noninvasive methods have the potential to change the future workflow of cancer management. The oral cavity is particularly accessible and, thus, such methods may serve as alternate/adjunct tools to traditional methods. Recently, in vivo human clinical studies have been initiated with a view to clinical translation of such technologies. A comprehensive review of optical methods in oral cancer diagnosis is presented. After an introduction to the epidemiology and etiological factors associated with oral cancers currently used, diagnostic methods and their limitations are presented. A thorough review of fluorescence, infrared absorption, and Raman spectroscopic methods in oral cancer diagnosis is presented. The applicability of minimally invasive methods based on serum/saliva is also discussed. The review concludes with a discussion on future demands and scope of developments from a clinical point of view. © 2015 Wiley Periodicals, Inc. Head Neck 38 : E2403–E2411, 2016 相似文献
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Anesthetic management of premature conjoined twins posted for nonseparation emergency surgery 下载免费PDF全文
Sunita Kulhari Amit Rastogi Ashish Kanaujia Poulomi Biswas Prabhat Kumar Singh 《Paediatric anaesthesia》2016,26(12):1204-1205
Craniopagus conjoined twins are rare, and the chance that an anesthesiologist might face the challenge of providing anesthesia for this condition is very rare. The incidence of conjoined twins ranges from 1 : 50 000 to 1 : 200 000 births. We describe the anesthetic management of a pair of premature craniopagus conjoined twins posted for emergency surgery prior to their separation. 相似文献
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Tacrolimus combined with corticosteroids versus Modified Ponticelli regimen in treatment of idiopathic membranous nephropathy: Randomized control trial 下载免费PDF全文