全文获取类型
收费全文 | 242169篇 |
免费 | 20917篇 |
国内免费 | 14354篇 |
专业分类
耳鼻咽喉 | 2181篇 |
儿科学 | 3053篇 |
妇产科学 | 4881篇 |
基础医学 | 28313篇 |
口腔科学 | 4217篇 |
临床医学 | 30950篇 |
内科学 | 39916篇 |
皮肤病学 | 2823篇 |
神经病学 | 13558篇 |
特种医学 | 8538篇 |
外国民族医学 | 96篇 |
外科学 | 26732篇 |
综合类 | 34199篇 |
现状与发展 | 48篇 |
一般理论 | 45篇 |
预防医学 | 15181篇 |
眼科学 | 6672篇 |
药学 | 24230篇 |
164篇 | |
中国医学 | 10917篇 |
肿瘤学 | 20726篇 |
出版年
2024年 | 698篇 |
2023年 | 3478篇 |
2022年 | 8673篇 |
2021年 | 11381篇 |
2020年 | 8388篇 |
2019年 | 7554篇 |
2018年 | 7995篇 |
2017年 | 6978篇 |
2016年 | 6672篇 |
2015年 | 10103篇 |
2014年 | 12705篇 |
2013年 | 11917篇 |
2012年 | 17579篇 |
2011年 | 19284篇 |
2010年 | 11792篇 |
2009年 | 9416篇 |
2008年 | 12810篇 |
2007年 | 12872篇 |
2006年 | 12428篇 |
2005年 | 12504篇 |
2004年 | 8646篇 |
2003年 | 7671篇 |
2002年 | 6613篇 |
2001年 | 5992篇 |
2000年 | 6127篇 |
1999年 | 6406篇 |
1998年 | 3649篇 |
1997年 | 3668篇 |
1996年 | 2788篇 |
1995年 | 2585篇 |
1994年 | 2233篇 |
1993年 | 1499篇 |
1992年 | 2290篇 |
1991年 | 1997篇 |
1990年 | 1665篇 |
1989年 | 1454篇 |
1988年 | 1264篇 |
1987年 | 1176篇 |
1986年 | 941篇 |
1985年 | 748篇 |
1984年 | 491篇 |
1983年 | 381篇 |
1982年 | 225篇 |
1981年 | 201篇 |
1980年 | 191篇 |
1979年 | 243篇 |
1978年 | 141篇 |
1977年 | 112篇 |
1976年 | 97篇 |
1974年 | 116篇 |
排序方式: 共有10000条查询结果,搜索用时 10 毫秒
31.
Yulong Lian Jing Xiao Chen Zhang Suzhen Guan Fuye Li Hua Ge 《Archives of environmental & occupational health》2016,71(2):74-84
The present study compared the level of occupational strain and work ability among Han, Hui, Uygur, Hui, and Kazakh teachers, and explored ethnic differences based on the associations of psychosocial factors at work, occupational strain, and work ability. A cross-sectional survey was conducted among 2,941 teachers in primary and secondary schools in Xinjiang Province, China. Psychosocial factors, occupational strain, and work ability were measured using the Occupation Stress Inventory—Revised Edition (OSI-R) and Work Ability Index. Han and Hui teachers experienced reduced work ability compared with Uygur and Kazakh teachers, and this finding was caused, in part, by exposure to psychosocial factors at work. The vocational and psychological strains caused by these factors play an important role in reduced work ability among all ethnic teacher groups. The findings indicate the importance of taking action to reduce occupational strain for promoting teachers' work ability in multiethnic workplaces. 相似文献
32.
33.
34.
35.
目的本研究立足于项目组前期研究的成果上,积极探索吉林辽宁两省目标设置水平的差异,并进一步探究受目标设置影响下的工作落实结果情况,探讨产生差异的原因。
方法以系统穷尽的方式收集吉林辽宁两省2000至2017年有关目标与工作落实情况的指标,利用Spearman相关和线性回归分析吉林辽宁两省目标设置对于突发应急工作落实情况的影响。
结果吉林辽宁两省突发应急领域的目标设置水平与工作落实情况总体均呈现上升趋势,截至2017年,吉林目标设置水平与工作落实情况分别为46%与60%,辽宁为60%与53.3%,且目标设置水平与工作落实呈正相关。
结论有公众需要为依据且定量可考的目标设置对于工作落实、推进、完善具有积极的正反馈作用,建立科学量化的突发应急目标设置评价体系是适宜可行的。 相似文献
36.
Gui-Qi Zhu Ke-Qing Shi Sha Huang Gui-Qian Huang Yi-Qian Lin Zhi-Rui Zhou Martin Braddock Yong-Ping Chen Ming-Hua Zheng 《Medicine》2015,94(11)
Major ursodeoxycholic acid (UDCA)-based therapies for primary biliary cirrhosis (PBC) include UDCA only, or combined with either methotrexate (MTX), corticosteroids (COT), colchicine (COC), or bezafibrate (BEF). As the optimum treatment regimen is unclear and warrants exploration, we aimed to compare these therapies in terms of patient mortality or liver transplantation (MOLT) and adverse events (AE).PubMed, the Cochrane Library, and Scopus were searched for randomized controlled trials up to August 31, 2014. We estimated the hazard ratios (HRs) for MOLT and odds ratios (ORs) for AE. A sensitivity analysis based on the dose of UDCA was also executed.Thirty-one eligible articles were included. Compared with COT plus UDCA, UDCA (HR 0.38, 95% confidence interval [CI] 0.09–1.39), BEF plus UDCA (HR 0.29, 95% CI 0.02–4.83), COC plus UDCA (HR 0.39, 95% CI 0.07–2.25), MTX plus UDCA (HR 0.28, 95% CI 0.05–1.63), or OBS (HR 0.49, 95% CI 0.11–2.01) all provided an increased risk of MOLT. With respect to drug AE profile, although not differing appreciably, BEF plus UDCA was associated with more AEs compared with UDCA (OR 3.16, 95% CI 0.59–20.67), COT plus UDCA (OR 2.27, 95% CI 0.15–33.36), COC plus UDCA (OR 1.00, 95% CI 0.09–12.16), MTX plus UDCA (OR 2.03, 95% CI 0.23–17.82), or OBS (OR 3.00, 95% CI 0.53–20.75). The results of sensitivity analyses were highly consistent with previous analyses.COT plus UDCA was the optimal UDCA-based regimen for both MOLT and AEs. BEF plus UDCA was most likely to cause AEs, whereas monotherapy with UDCA and coadministriation of COT plus UDCA appeared to be associated with the fewest AEs for PBC treatment. 相似文献
37.
Xiujuan Tian Zhiying Chen Shaomin Shi Xianwen Wang Wanli Wang Ning Li Jing Wang 《Medicine》2015,94(37)
Oral cancer, predominantly oral squamous cell carcinoma (OSCC), is one of the most leading causes of cancers worldwide. Due to a low 5-year survival rate, highly effective methods for the early detection of OSCC are totally needed. MicroRNAs (miRNAs), as promising biomarkers, can bring insights into tumorigenesis of oral cancers. However, studies on the accuracy of miRNAs detection in OSCC have inconsistent conclusions, leading us to conduct this meta-analysis. The aim of this study was to systematically review the articles investigating the diagnostic value of miRNAs in OSCC.The PubMed, Embase, Chinese National Knowledge Infrastructure (CNKI), Web of Science were searched (updated to June 11th, 2015) to identify all articles evaluating the diagnostic yield of miRNAs for OSCC. The pooled sensitivity, specificity, and other diagnostic parameters were used to assess the performance of miRNAs assays on OSCC detection. Statistical analysis was conducted by employing the R software.The present meta-analysis comprised 23 studies from 10 articles, including 598 OSCC patients and 320 healthy individuals, available for analysis. The summary receiver operator characteristic (SROC) curve was plotted. Meanwhile, the pooled diagnostic parameters and the area under curve (AUC) were calculated based on all included studies. The pooled diagnostic parameters calculated from all 23 studies were as follows: pooled sensitivity of 0.759 (95% CI: 0.701–0.809), pooled specificity of 0.773 (95% CI: 0.713–0.823) and AUC of 0.832, which indicates a relatively high diagnostic accuracy of miRNAs in differentiating OSCC patients from healthy controls. Meanwhile, In addition, subgroup analyses were conducted to access the heterogeneity between studies, which is based on specimen (serum/plasma/blood/saliva/ tissue) and ethnicity (Asian/Caucasian).In summary, our meta-analysis suggests that miRNAs might be used in noninvasive screening tests for OSCC, which needs further large-scale studies to be validated. 相似文献
38.
39.
40.
Richard Kim Elaine Tan Emily Wang Amit Mahipal Dung-Tsa Chen Biwei Cao Fadzai Masawi Cindy Machado James Yu Dae Won Kim 《The oncologist》2020,25(12):e1893-e1899
Lessons Learned
- The combination of trametinib and sorafenib has an acceptable safety profile, albeit at doses lower than approved for monotherapy.
- Maximum tolerated dose is trametinib 1.5 mg daily and sorafenib 200 mg twice daily.
- The limited anticancer activity observed in this unselected patient population does not support further exploration of trametinib plus sorafenib in patients with hepatocellular carcinoma.