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131.
Meghan T. Hession M.D. Shannon M. Campbell D.O. Sophie J. Balk M.D. Deborah L. Cummins M.D. 《Pediatric dermatology》2013,30(5):626-627
This report presents results from an online survey of New York State pediatricians regarding their counseling habits and attitudes toward indoor tanning among adolescents, as well as their awareness of current legislation that restricts youth access to tanning beds. 相似文献
132.
Jaelyn R. Farris Shannon S. Carothers Bert Jody S. Nicholson Kerrie Glass John G. Borkowski 《Administration and policy in mental health》2013,40(3):211-223
This study assessed the secondary effects of a parent training intervention program on maternal adjustment, with a focus on understanding ways in which program efficacy differed for participants as a function of whether or not their children had behavior problems. Mothers (N = 99) of toddlers (2–3 years of age) were randomly assigned to receive one of three levels of intervention: (1) informational booklet (2) booklet + face-to-face parent training sessions, or (3) booklet + web-based parent training sessions. Findings indicated that all levels of intervention were associated with increases in maternal well-being for participants with typically developing children. Mothers of toddlers with behavior problems, however, did not benefit from receiving only the booklet but significantly benefitted from receiving either the face-to-face or web-based interventions. Findings are discussed in terms of efficient and efficacious program dissemination and the resulting implications for public policy. 相似文献
133.
134.
Jeffrey T. West Sheena M. Horning Kelli J. Klebe Shannon M. Foster R. Elisabeth Cornwell David Perrett 《Experimental aging research》2013,39(2):146-168
Background/Study Context: An emotion recognition task that morphs emotional facial expressions from an initial neutral expression to distinct increments of the full emotional expression was administered to 482 individuals, 20 to 89 years of age. Methods: Participants assessed six basic emotions at 25%, 50%, 75%, and 100% of the full facial expression. Results: Participants in the three oldest age groups (60s, 70s, and 80s) demonstrated decreased performance for the recognition of the fear, anger, and sad emotions. Increased age was associated with increased recognition rates for the disgust expression, whereas no age effect was detected for the happy and surprise expressions. Covariate analyses revealed age effects were reduced by processing speed, but were unaffected by decision-making ability. The effects of age on individual emotions and levels of presentation are discussed. Conclusion: These findings suggest that age has the greatest impact on the recognition of the sad emotion and the greatest age effect at the 50% level of presentation across the adult life span. 相似文献
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136.
Shannon C. Wieland Christopher A. Cassa Kenneth D. Mandl Bonnie Berger 《Proceedings of the National Academy of Sciences of the United States of America》2008,105(46):17608-17613
Datasets describing the health status of individuals are important for medical research but must be used cautiously to protect patient privacy. For patient data containing geographical identifiers, the conventional solution is to aggregate the data by large areas. This method often preserves privacy but suffers from substantial information loss, which degrades the quality of subsequent disease mapping or cluster detection studies. Other heuristic methods for de-identifying spatial patient information do not quantify the risk to individual privacy. We develop an optimal method based on linear programming to add noise to individual locations that preserves the distribution of a disease. The method ensures a small, quantitative risk of individual re-identification. Because the amount of noise added is minimal for the desired degree of privacy protection, the de-identified set is ideal for spatial epidemiological studies. We apply the method to patients in New York County, New York, showing that privacy is guaranteed while moving patients 25—150 times less than aggregation by zip code. 相似文献
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138.
Erica K. Husser PhD Donna M. Fick PhD Marie Boltz PhD Priyanka Shrestha RN MS Jonathan Siuta MD Shannon Malloy MA Abigail Overstreet MA Douglas L. Leslie PhD Long Ngo PhD Yoojin Jung MS PhD Sharon K. Inouye MD MPH Edward R. Marcantonio MD MSc 《Journal of the American Geriatrics Society》2021,69(5):1349-1356
139.
Huijin Dong Johanna R. Mora Catherine Brockus Shannon D. Chilewski Robert Dodge Colin Merrifield W. Matthew Dickerson Binodh DeSilva 《The AAPS journal》2015,17(6):1511-1516
Immunogenicity testing for PEGylated biotherapeutics should include methods to detect both anti-protein and anti-PEG antibodies (anti-PEG). Although some methods have been published for the detection of anti-PEG antibodies, the information is incomplete and, in some cases, reagents used (such as Tween-20) are known to interfere with detection. This rapid communication describes the use of BioScale’s Acoustic Membrane MicroParticle (AMMP®) technology using the ViBE® Workstation to measure anti-PEG antibodies in human serum samples. Briefly, a sample spiked with monoclonal human IgG anti-PEG antibody is diluted in buffer and incubated with paramagnetic beads coated with linear chain mPEG to capture anti-PEG antibodies. The complex is then captured on an acoustic membrane coated with Protein A. The change in mass on the membrane caused by the binding of the complex to the membrane results in a signal proportional to the mass of anti-PEG antibodies. The data indicate that an assay with a sensitivity of less than 1000 ng/mL for IgG is achievable. This level of sensitivity is better than current published reports on IgG anti-PEG antibody detection.KEY WORDS: acoustic membrane microparticle technology, anti-peg antibodies, emerging technology, immunogenicity assays, pegylated biotherapeutics 相似文献
140.
Flaherty Susan M. Moran Christopher J. Scott-Vernaglia Shannon E. 《Digestive diseases and sciences》2022,67(2):364-366
Digestive Diseases and Sciences - 相似文献