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91.
Rahman SM Dobrzyn A Dobrzyn P Lee SH Miyazaki M Ntambi JM 《Proceedings of the National Academy of Sciences of the United States of America》2003,100(19):11110-11115
We have shown previously that mice with a targeted disruption in the stearoyl-CoA desaturase 1 gene (SCD1-/-) have increased insulin sensitivity compared with control mice. Here we show that the SCD1-/- mice have increased insulin signaling in muscle. The basal tyrosine phosphorylation of the insulin receptor and insulin receptor substrates 1 and 2 are elevated. The tyrosine phosphorylation of insulin-like growth factor-1 receptor was similar between SCD1+/+ and SCD1-/- mice. The association of insulin receptor substrates 1 and 2 with alphap85 subunit of phosphatidylinositol 3-kinase as well as the phosphorylation of Akt-Ser-473 and Akt-Thr-308 are also elevated in the SCD1-/- mice. Interestingly, the mRNA levels, protein mass, and activity of the protein-tyrosine phosphatase-1B implicated in the attenuation of the insulin signal are reduced in the SCD1-/- mice, whereas the levels of the leukocyte antigen-related protein phosphatase are similar between two groups of mice. The content of glucose transporter 4 in the plasma membrane and basal as well as insulin-mediated glucose uptake are increased in the SCD1-/- mice. In addition, the muscle glycogen content and the activities of glycogen synthase and phosphorylase are increased in the SCD1-/- mice. We hypothesize that loss of SCD1 function induces increased insulin signaling at least in part by a reduction in the expression of protein-tyrosine phosphatase 1B. SCD1 could be a therapeutic target in the treatment of diabetes. 相似文献
92.
Majid Shafiq Zaman Shah Ayesha Saleem Maham T Siddiqi Kashif S Shaikh Farah F Salahuddin Rizwan Siwani Haider Naqvi 《Substance abuse treatment, prevention, and policy》2006,1(1):31-7
Background
Drug abuse is hazardous and known to be prevalent among young adults, warranting efforts to increase awareness about harmful effects and to change attitudes. This study was conducted to assess the perceptions of a group of medical students from Pakistan, a predominantly Muslim country, regarding four drugs namely heroin, charas, benzodiazepines and alcohol. 相似文献93.
目的:报道特发性黄斑裂孔行玻璃体切除并内界膜(ILM)剥离术后,未曾报道的并发症。方法:回顾性分析1996—2001年间,232例连续性患者因特发性黄斑裂孔进行玻璃体切除并内界膜(ILM)剥离术。4例患者术后发现有医源性偏心性黄斑裂孔。利用光学相干断层扫描检查这些黄斑裂孔。结果:术 相似文献
94.
ZA Bhutta 《Archives of disease in childhood》1996,75(3):214-217
The risk factors for mortality were analysed in a consecutive group of 1158 children presenting to the Aga Khan University Medical Center, Karachi, with multidrug resistant typhoid fever that had been proved on culture. There were 19 deaths, representing an overall case fatality rate of 1.6%. Multidrug resistant typhoid was associated with a more severe clinical illness and higher rates of toxicity, hepatomegaly, hypotensive shock, and death. Irrespective of drug resistance status, typhoid fever was found to be a more severe illness in young infants with significantly higher rates of diarrhoea, hypotensive shock, and mortality. Univariate analysis of admission characteristics associated with increased risk for mortality revealed significant association with younger age (p < 0.05), hypotensive shock or hypothermia (p < 0.001), obtundation (p < 0.001), seizures (p < 0.05), anaemia at admission (p < 0.005), and leucocytosis (p < 0.001). Logistic regression analysis of risk factors for mortality showed persistent association of hypothermia, toxicity, and anaemia with mortality. The data provides evidence that multidrug resistant typhoid in childhood is associated with increased risk of mortality, especially in infancy and closer attention to several risk factors for increased morbidity and case fatality rates may lead to improved outcome of treatment. 相似文献
95.
While the impact of seatbelts on injury is favorable, their use is also associated with unique and previously unrecognized patterns of injury. Two cases of combined subclavian and vertebral artery injury, when lap shoulder harness restraints were used, are presented. 相似文献
96.
97.
Reimschuessel R Stewart L Squibb E Hirokawa K Brady T Brooks D Shaikh B Hodsdon C 《The AAPS journal》2005,7(2):E288-E327
Information about drug residues and pharmacokinetic parameters in aquatic species is relatively sparse. In addition, it is difficult to rapidly compare data between studies due to differences in experimental conditions, such as water temperatures and salinity. To facilitate the study of aquatic species drug metabolism, we constructed a Fish Drug/Chemical Analysis Phish-Pharm (FDA-PP) database. This database consists of more than 400 articles that include data from 90 species (64 genera) of fish. Data fields include genus, species, water temperatures, the average animal weight, sample types analyzed, drug (or chemical) name, dosage, route of administration, metabolites identified, method of analysis, protein binding, clearance, volume of distribution in a central compartment (Vc) or volume of distribution at steady-state (Vd), and drug half-lives (t((1/2))). Additional fields list the citation, authors, title, and Internet links. The document will be periodically updated, and users are invited to submit additional data. Updates will be announced in future issues of The AAPS Journal. This database will be a valuable resource to investigators of drug metabolism in aquatic species as well as government and private organizations involved in the drug approval process for aquatic species. 相似文献
98.
99.
100.
Shaikh AH Rana M Shaikh AH 《Journal of the College of Physicians and Surgeons--Pakistan : JCPSP》2005,15(9):580-581
This case report describes a young man with bilateral flank pain for one year following a gunshot trauma to abdomen. On ureteroscopy a pellet was found in the right ureter. 相似文献