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101.
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Bala R. Subramanyam M.D. Emil J. Balthazar B. Nagesh Raghavendra Mariano R. Madamba 《Abdominal imaging》1982,7(1):47-51
Five cases of exophytic gastrointestinal leiomyosarcoma were evaluated by sonography. In 3 of the 5 cases, identification of intraluminal air or intestinal lumen in an eccentric location to the mass was helpful in recognizing the exophytic nature of the mass. Tumor necrosis was present in all of the masses and also in 1 case of hepatic metastasis. Recognition of the exophytic nature of the mass and the presence of tumor necrosis favor the diagnosis of leiomyosarcoma. 相似文献
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Vemuganti L Raghavendra Rao Mustafa K Ba?kaya A Muralikrishna Rao Aclan Do?an Robert J Dempsey 《Brain research》1998,783(1):627
There is increasing evidence that the elevated levels of polyamines play an important role in the secondary injury following traumatic brain injury (TBI). Ornithine decarboxylase (ODC) is the rate-limiting enzyme of polyamine biosynthesis. Presently, we measured the ODC protein levels by Western blot analysis in the cerebral cortex of rats sacrificed at 2 h, 6 h, 24 h, 72 h and 168 h after controlled cortical impact injury. TBI resulted in a significant increase in ODC protein levels (2.5 to 5.5 fold, P<0.05) and enzyme activity (13 to 21 fold, p<0.01) between 2 and 6 h after the injury. ODC protein levels and enzyme activity returned to normal, control levels by 72 h after the injury. Increased ODC protein and enzyme activity could contribute to vasogenic edema and the pathogenesis of neuronal dysfunction after TBI by stimulating the formation of polyamines. 相似文献
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Endomyocardial fibrosis 总被引:2,自引:0,他引:2
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The ability to control the oxygen level to which cells are exposed in tissue culture experiments is crucial for many applications.
Here, we design, develop and test a microbioreactor (MBR) for long-term cell culture studies with the capability to accurately
control and continuously monitor the dissolved oxygen (DO) level in the cell microenvironment. In addition, the DO level can
be controlled independently from other cues, such as the viscous shear-stress acting on the cells. We first analyze the transport
of oxygen in the proposed device and determine the materials and dimensions that are compatible with uniform oxygen tension
and low shear-stress at the cell level. The device is also designed to culture a statistically significant number of cells.
We use fully transparent materials and the overall design of the device is compatible with live-cell imaging. The proposed
system includes real-time read-out of actual DO levels, is simple to fabricate at low cost, and can be easily expanded to
control the concentration of other microenvironmental solutes. We performed control experiments in the absence of cells to
demonstrate that the MBR can be used to accurately modulate DO levels ranging from atmospheric level to 1%, both under no
flow and perfusion conditions. We also demonstrate cancer cell attachment and viability within the MBR. The proposed MBR offers
the unprecedented capability to perform on-line measurement and analysis of DO levels in the microenvironment of adherent
cultures and to correlate them with various cellular responses. 相似文献
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