全文获取类型
收费全文 | 1314篇 |
免费 | 98篇 |
国内免费 | 9篇 |
专业分类
耳鼻咽喉 | 23篇 |
儿科学 | 14篇 |
妇产科学 | 21篇 |
基础医学 | 188篇 |
口腔科学 | 8篇 |
临床医学 | 134篇 |
内科学 | 281篇 |
皮肤病学 | 18篇 |
神经病学 | 144篇 |
特种医学 | 80篇 |
外科学 | 259篇 |
综合类 | 3篇 |
预防医学 | 75篇 |
眼科学 | 7篇 |
药学 | 83篇 |
肿瘤学 | 83篇 |
出版年
2024年 | 2篇 |
2023年 | 10篇 |
2022年 | 28篇 |
2021年 | 50篇 |
2020年 | 34篇 |
2019年 | 63篇 |
2018年 | 64篇 |
2017年 | 35篇 |
2016年 | 48篇 |
2015年 | 54篇 |
2014年 | 81篇 |
2013年 | 84篇 |
2012年 | 132篇 |
2011年 | 136篇 |
2010年 | 89篇 |
2009年 | 49篇 |
2008年 | 102篇 |
2007年 | 82篇 |
2006年 | 70篇 |
2005年 | 53篇 |
2004年 | 43篇 |
2003年 | 37篇 |
2002年 | 28篇 |
2001年 | 3篇 |
2000年 | 3篇 |
1999年 | 2篇 |
1998年 | 3篇 |
1996年 | 1篇 |
1995年 | 1篇 |
1993年 | 3篇 |
1991年 | 3篇 |
1989年 | 2篇 |
1988年 | 6篇 |
1987年 | 1篇 |
1986年 | 4篇 |
1982年 | 3篇 |
1981年 | 3篇 |
1980年 | 1篇 |
1979年 | 2篇 |
1977年 | 3篇 |
1974年 | 2篇 |
1972年 | 1篇 |
排序方式: 共有1421条查询结果,搜索用时 390 毫秒
971.
972.
973.
Nicolas Guéguen Sebastien Meineri Virginie Charles-Sire 《Journal of behavioral medicine》2010,33(6):466-473
Though the positive effect of touch on compliance has been widely reported in the social psychology literature, a new evaluation
has been made in a health setting. Six general practitioners were instructed to touch (or not) their patients on the forearm
for 1–2 s. Patients who suffered from mild pharyngitis were solicited by the practitioners at the end of the consultation
for a verbal promise to take the antibiotic medication as prescribed. One week later, patients were contacted at home to determine
the number of pills that had been taken and to evaluate the practitioner. Touch increased medication adherence in both male
and female patients, but was associated with a greater increase in male patients. It was also found that practitioners were
perceived to be more concerned about their patients by those in the touch condition. Practitioner competence appeared to be
slightly higher in the touch condition. The theoretical implications of this positive effect of tactile contact are discussed
and the practical interest for practitioners is highlighted, showing how this nonverbal technique could help them to increase
the medication adherence of their patients. 相似文献
974.
Fabienne Moritz Jacques Benichou Marc Vanheste Jean-Christophe Richard Sebastien Line Marie-France Hellot Guy Bonmarchand Jean-Michel Muller 《European journal of emergency medicine》2003,10(3):204-208
This study aimed to assess the short-term respiratory effects of a new portable device that delivers a continuous positive airway pressure via a face mask (Boussignac-CPAP) in patients with severe acute cardiogenic pulmonary oedema, and the feasibility of using this technique in an emergency department. We prospectively studied 30 consecutive patients with acute cardiogenic pulmonary oedema. They were randomly assigned either to the Boussignac-CPAP valve, which delivered oxygen, or to standard oxygen delivery for a duration of 30 min. The end-expiratory pressure reached 9.3+/-0.3 cm H2O with the Boussignac-CPAP valve. At the end of the 30 min period, the decreases in respiratory rate and muscular activity were significantly greater among patients assigned to the Boussignac-CPAP valve compared with those on standard oxygen delivery [24+/-1.6 breaths/min, median 24 (15-37) versus 28.5+/-1.9, median 27 (16-38) and 1.3+/-0.2, median 1 (0-4) versus 2.7+/-0.3, median 2 (0-4), respectively]. Moreover, the arterial oxygen tension to inspired oxygen concentration ratio and tidal volume were improved at the end of the 30 min Boussignac-CPAP period compared with baseline. Boussignac-CPAP was easily implemented and no side-effects were reported. Continuous positive pressure delivered using the Boussignac-CPAP device is feasible in an emergency care setting. It can quickly improve respiratory distress in acute cardiogenic pulmonary oedema patients. A larger trial should be initiated in such an emergency care setting to demonstrate the effectiveness of the Boussignac-CPAP device. 相似文献
975.
Rachel F. Rodgers PhD Caterina Lombardo PhD Silvia Cerolini PhD Debra L. Franko PhD Mika Omori PhD Matthew Fuller-Tyszkiewicz PhD Jake Linardon PhD Philippe Courtet MD PhD Sebastien Guillaume MD PhD 《The International journal of eating disorders》2020,53(7):1166-1170
The current COVID-19 pandemic has created a global context likely to increase eating disorder (ED) risk and symptoms, decrease factors that protect against EDs, and exacerbate barriers to care. Three pathways exist by which this pandemic may exacerbate ED risk. One, the disruptions to daily routines and constraints to outdoor activities may increase weight and shape concerns, and negatively impact eating, exercise, and sleeping patterns, which may in turn increase ED risk and symptoms. Relatedly, the pandemic and accompanying social restrictions may deprive individuals of social support and adaptive coping strategies, thereby potentially elevating ED risk and symptoms by removing protective factors. Two, increased exposure to ED-specific or anxiety-provoking media, as well as increased reliance on video conferencing, may increase ED risk and symptoms. Three, fears of contagion may increase ED symptoms specifically related to health concerns, or by the pursuit of restrictive diets focused on increasing immunity. In addition, elevated rates of stress and negative affect due to the pandemic and social isolation may also contribute to increasing risk. Evaluating and assessing these factors are key to better understanding the impact of the pandemic on ED risk and recovery and to inform resource dissemination and targets. 相似文献
976.
977.
978.
979.
Suraya Bondy Camilla Tajzler Sebastien J. Hotte Anil Kapoor Kevin Zbuk Aly-Khan A. Lalani 《Current oncology (Toronto, Ont.)》2021,28(1):226
Li-Fraumeni Syndrome (LFS) is defined by germline mutations of the p53 tumour suppressor gene. Adrenocortical carcinoma (ACC) is a rare aggressive malignancy that is commonly associated with LFS. Most LFS-linked ACC cases occur in children, and limited research has been dedicated to the clinical outcomes and genomics of adult cases with LFS-linked ACC. We report on a 34-year-old female who was diagnosed with three separate malignancies: stage III invasive ductal carcinoma of the right breast, metastatic ACC from the right adrenal gland, and grade 2 pleomorphic sarcoma of the left hand. Her invasive breast ductal carcinoma was treated with neoadjuvant chemotherapy, and she received a bilateral mastectomy after her LFS was confirmed with genetic blood testing. Adrenal ACC was initially treated with a right nephrectomy and adrenalectomy, followed by adjuvant mitotane and two lines of chemotherapy after disease recurrence. Her hand sarcoma was treated by second ray amputation. Further, we conducted deep next-generation sequencing of each of her unique tumour tissue samples using FoundationONE CDx. A whole-genome shot capture followed by in vitro sequencing performed by the Illumina® HiSeq platform revealed a germline P191fs*18 TP53 mutation across all three tissue samples. This case provides insight into the genomics and clinical characteristics of LFS-linked adult-onset ACC and demonstrated that p53 mutations were preserved throughout each malignancy, without apparent treatment pressures on genomic profiling. This case reinforces the critical importance of adopting best practices for LFS, which include the implementation of highly vigilant screening and management of care in a multidisciplinary setting. 相似文献
980.