Possibilities of sterility therapy in a patient with a premature menopause due to an X-chromosomal anomaly - a case report

Our report concerns a patient with a climacterium praecox and an X-chromosomal anomaly (86% 46, XX; 7% 47, XXX; 7% 45, X0) desiring to give birth. She conceived once after down-regulation of the gonadotrophins by means of a cyclical hormone replacement therapy followed by gonadotrophin stimulation, as well as a second time under down-regulation with a GnRH-analogue and gonadotrophin stimulation. On the basis of the case report and of the literature, a possible interval therapy in such a patient, especially one even with increasing ovarian insufficiency, will be portrayed and discussed.     

Arthus phenomenon like skin reaction and antibody pattern in rabbits immunized with various myxovirus fractions

Summary Rabbits immunized with measles- and mumps viruses grown in monkey kidney cells and chick embryo fibroblasts and with their water- and organic solvent fractions obtained by Tween-ether treatment developed immediate type skin hyperreactivity (Arthus phenomenon-like) to challenge with the complete viruses and calf serum, but not to challenge with tissue antigens prepared in the absence of calf serum. The skin reaction in animals immunized with ether fractions was stronger than in animals immunized with water fractions or complete virus, respectively. The intensity of individual skin reactions in each animal was better correlated to the presence of precipitating antibody against calf serum or a component thereof than to the HI titer against the viruses used for immunization.The seriological tests for measles and mumps were supported by the Bundesminister für Jugend, Familie und Gesundheit, Bonn, BRD.     

The influence of experimental diabetes on the distribution of LDH-isoenzymes in rat skeletal muscle (author's transl)]

The distribution of LDH-isoenzymes from homogenate-supernatant of M. soleus of normal and streptozotocin-diabetic male rats was investigated by agargel-electrophoresis. Five LDH-isoenzymes could be detected in the M. soleus of normal rats; the average proportion of H-subunits was 69.1% (age 3-4 month) resp. 69.6% (age 13 month) from the total value. In male rats of the same age a mild diabetes was induced by intravenous injection of 65 mg streptozotocin per kg body weight. In the M. soleus of these animals also 5 LDH-isoenzymes were detected. After 1-2 month duration of diabetes the LDH1 is decreased from 30.3% of controls to 18.2% and the LDH4 is increased from 11.1% of controls to 20.1%. The H-subunit value decreased to 61.9% from the total value. In long term diabetes (11 month) the values of single fractions and the H-subunit value did not differ from those of controls. The findings are discussed considering the composition of M. soleus on different fiber types and the influence of diabetic conditions.     

Infant Vocalization: An Index of Maternal Attitude Toward the Child

Brief observations of mother-stimulated infant vocalizationwere perform ed during pediatric clinic visits on 4- to 6-month-oldinfants to determine whether mothers with positive attitudestoward the pregnancy and/or the in fant would have infants whovocalized more during clinic visits. Mothers with more positiveattitudes toward the pregnancy, assessed prenatally, had infantswho showed significantly more vocalization during clinic visitsat 5 months, 6 months, and the combination of 5 and 6 months.Mothers with more positive attitudes toward the infant had infantswho showed signcantly more vocalization at 4 months and thecombination of observations at 4 months and 6 months. Resultssuggest that brief observations of vocalization during clinicvisits may be useful as a rough index of the quality of themother-child interaction.     

Incidence and diagnosis of acute rheumatic fever in Denmark, 1980 and 1983. A retrospective analysis of the fulfillment of the revised Jones criteria in hospitalized patients

A review of 1547 official hospital record summaries concerning discharges during the period 1980 through 1983 of patients whose diagnoses had been coded as acute rheumatic fever revealed that in only 61% of the cases had this illness been diagnosed or suspected. A substantial proportion of the remaining patients had had acute non-rheumatic pericarditis diagnosed. The medical records were analyzed for 141 patients diagnosed in 1980 or 1983 by hospital departments as having acute rheumatic fever with regard to the revised Jones criteria. They were fulfilled in 47 patients, 23 of whom were considered unlikely cases of rheumatic fever. Eight patients were considered possible cases, although they did not fulfill the revised Jones criteria. The current annual incidence of acute rheumatic fever was estimated to be at most 0.3 per 100,000 inhabitants.