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991.
Rafiye Ciftciler Haluk Demiroglu Yahya Buyukasık Mufide Okay Salih Aksu Nilgun Sayınalp Umit Yavuz Malkan Ibrahim Celalettin Haznedaroglu Osman Ozcebe Hakan Goker 《Transfusion and apheresis science》2018,57(6):752-755
Background and Aim
This is a retrospective study aiming to investigate the effect of the number of high dose cytarabine-based chemotherapy (HiDAC) courses in patients with acute myeloid leukemia before allogenic stem cell transplantation (ASCT).Materials and Methods
A total of 110 patients with acute myeloid leukemia who received ASCT between 2001 and 2018 were included in the study.Results
Of the 110 patients, 25 (23%) patients received one course of HiDAC, 42 (38%) patients received two courses of HiDAC, 34 (31%) patients received three courses of HiDAC and 9 (8%) patients received four courses of HiDAC. Median follow-up for survivors was 71 months (range 4–186) for all patients. The 3-year overall survival for patients who received one course of HiDAC and patients who received more than one course of HiDAC were 49% and 70%, respectively (p?=?0.29). The 3-year disease free survival (DFS) for patients who received one course of HiDAC and patients who received more than one course of HiDAC were 38% and 66%, respectively (p?=?0.05). There was no statistically significant difference in OS between patients who received one or more than one consolidation chemotherapy. But there was nearly a statistically significant difference between patients who received one or more than one consolidation chemotherapy in DFS.Conclusion
In conclusion, the administration of more than one consolidation chemotherapy may provide longer DFS, however the number of consolidation chemotherapy is not associated with statistically significant differences in overall outcomes. 相似文献992.
Yang Y Goh SY Tan SB Ho HJ Emmanuel S Wang P Ng HS 《European Journal of Internal Medicine》2012,23(1):e1-e4
Summary
Diabetes mellitus (DM) has been declared as a global public health threat to society. However, the burden of the disease in elderly Asian patients has not been described. The aim of the study is to assess the disease burden of DM and its associated adverse outcomes in elderly patients from an Asian hospital using the hospital inpatient database.Methods
Retrospective study of hospital discharge database from 2004 to 2008 to identify patients aged 65 years and above with DM and its associated ‘adverse outcomes’ using International Statistical Classification of Diseases and Related Health Problems, 9th Revision, Australian Modification (ICD-9-AM) codes.Results
Of 89,875 hospitalized patients aged 65 years and above over the 5 years, 31,124 (34.6%) patients had DM, and the percentage of DM cases increased steadily from 34.3% to 35.6%. Prevalence of DM-associated adverse outcomes was higher in DM patients than in non-DM patients (53.8% vs. 31.5%, p < 0.001). For trends over time, the adverse outcomes decreased in both DM patients (58.1% to 53.6%) and non-DM patients (34.3% to 31.4%, all p < 0.001). All disease-specific adverse outcomes except renal disease decreased over time both in DM and non-DM patients (all p < 0.05). There were increased trends over time for renal disease in both DM patients (16.1% to 23.2%, p < 0.001) and non-DM patients (6.7% to 10.4%, p < 0.001).Conclusion
The burden of DM in this group of elderly patients is high. Elderly patients with DM experienced much higher rates of the adverse outcomes. 相似文献993.
The purpose of this study was to evaluate transcutaneous electrical nerve stimulation (TENS) and other common treatment methods used in the process of wound healing in terms of the expression levels of pro-inflammatory cytokines. In the study, 24 female and 24 male adult Wistar–Albino rats were divided into five groups: (1) the non-wounded group having no incision wounds, (2) the control group having incision wounds, (3) the TENS (2 Hz, 15 min) group, (4) the physiological saline (PS) group and (5) the povidone iodine (PI) group. In the skin sections, interleukin-1 beta (IL-1β), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α) were assessed with enzyme-linked immunosorbent assay and immunohistochemical methods. In the non-wounded group, the expression of IL-1β, IL-6, and TNF-α signaling molecules was weaker in the whole tissue; however, in the control group, significant inflammatory response occurred, and strong cytokine expression was observed in the dermis, granulation tissue, hair follicles, and sebaceous glands (P?<?0.05). In the TENS group, the decrease in TNF-α, IL-1β, and IL-6 immunoreaction in the skin was significant compared to the other forms of treatment (P?<?0.05). Distinctive decreases of pro-inflammatory cytokines observed in the dermis in the TENS group suggest that TENS shortened the healing process by inhibating the inflammation phase. 相似文献
994.
Elias B Mignone J Hall M Hong SP Hart L Sareen J 《Social science & medicine (1982)》2012,74(10):1560-1569
It has been theorized that suicide behaviours amongst indigenous peoples may be an outcome of mass trauma experienced as a result of colonization. In Canada, qualitative evidence has suggested that the Indian Residential School System set in motion a cycle of trauma, with some survivors reporting subsequent abuse, suicide, and other related behaviours. It has been further postulated that the effects of trauma can also be passed inter-generationally. Today, there are four generations of Canadian First Nations residential school survivors who may have transmitted the trauma they experienced to their own children and grandchildren. No empirical study has ever been undertaken to demonstrate this dynamic. This study is therefore the first to investigate whether a direct or indirect exposure to Canada's residential school system is associated with trauma and suicide behaviour histories. Data were collected in 2002/2003 from a representative sample of Manitoba, Canada, First Nations adults (N = 2953), including residential (N = 611) and non-residential school attendees (N = 2342). Regression analyses showed that for residential school attendees negative experiences in residential school were associated with a history of abuse, and that this history and being of younger age was associated with a history of suicide thoughts, whereas abuse history only was associated with a history of suicide attempts. For First Nations adults who did not attend a residential school, we found that age 28-44, female sex, not having a partner, and having a parent or grandparent who attended a residential school was associated with a history of abuse. This history, along with age and having had a parent or grandparent who attended residential school was associated with a history of suicide thoughts and attempts. In conclusion, this is the first study to empirically demonstrate, at the population level, the mental health impact of the residential school system on survivors and their children. 相似文献
995.
Brett?G?MitchellEmail author Richard?Say Anne?Wells Fiona?Wilson Linda?Cloete Lucinda?Matheson 《BMC nursing》2014,13(1):43
Background
In recent year, national bodies have been actively addressing the increasing concern on the spread of healthcare-associated infections (HAIs). The current study measures the knowledge, intentions and beliefs of third-year Australian nursing students on key infection prevention and control (IPC) concepts.Methods
A cross-sectional study of final-year undergraduate nursing students from Schools of Nursing at six Australian universities was undertaken. Students were asked to participate in an anonymous survey. The survey explored knowledge of standard precautions and transmission based precautions. In addition intentions and beliefs towards IPC were explored.Results
349 students from six universities completed the study. 59.8% (95% CI 58.8–60.8%) of questions were answered correctly. Significantly more standard precaution questions were correctly answered than transmission-based precaution questions (p?<?0.001). No association was found between self-reported compliance with IPC activities and gender or age. Certain infection control issues were correlated with the percentage of correctly answered transmission-based precaution questions. The participants were most likely to seek infection control information from an infection control professional.Conclusion
Knowledge on transmission-based precautions was substandard. As transmission-based precautions are the foundation of IPC for serious organisms and infections, education institutions should reflect on the content and style of educational delivery on this topic.996.
Julie W Rutten Joost Haan Gisela M Terwindt Sjoerd G van Duinen Elles MJ Boon 《Expert review of molecular diagnostics》2014,14(5):593-603
CADASIL is an autosomal dominant inherited disease, characterized by mid-adult onset of cerebrovascular disease and dementia. CADASIL is caused by mutations in the NOTCH3 gene, which encodes the NOTCH3 protein. Pathogenic mutations in CADASIL are highly distinctive in the sense that they lead to the loss or gain of a cysteine residue in 1 of the 34 EGFr domains of the NOTCH3 protein. The majority are missense mutations, but small deletions, insertions and splice-site mutations have been reported, which typically also lead to a numerical cysteine alteration. Whether numerical cysteine-altering mutations are a rule in CADASIL remains subject of debate, as there are reports suggesting pathogenicity of other types of mutations. However, for most of these the association with CADASIL was later revoked or is questionable. Here, we discuss and provide recommendations for the interpretation of NOTCH3 mutations in the diagnosis of CADASIL. 相似文献
997.
998.
Patients with rickettsial infection may present with encephalitis or meningitis but neurologic involvement is rare in murine typhus. Here, we report two patients with Rickettsia typhi meningitis who presented with cranial neuropathy, presumably caused by two distinct disease processes. Recognition of the disease manifestations is important because rickettsial infections are potentially associated with significant morbidity. Simple effective treatments are available. 相似文献
999.
Anaemia of chronic disease in rheumatoid arthritis: in vivo effects of tumour necrosis factor alpha blockade 总被引:7,自引:0,他引:7
Davis D; Charles PJ; Potter A; Feldmann M; Maini RN; Elliott MJ 《Rheumatology (Oxford, England)》1997,36(9):950-956
Anaemia of chronic disease (ACD) is a common feature of active rheumatoid
arthritis (RA). Inflammatory cytokines, particularly tumour necrosis factor
alpha (TNF-alpha), interleukin-1 (IL-1) and interleukin- 6 (IL-6), are
thought to contribute to the pathogenesis of ACD, possibly by inhibiting
erythropoietin (EPO) production. In this study, we examined the in vivo
effects of TNF-alpha blockade with a chimeric monoclonal antibody, cA2, on
erythropoiesis in RA patients with ACD. Administration of cA2 led to a
dose-dependent increase in haemoglobin levels compared to placebo and these
changes were accompanied by a reduction in both EPO and IL-6 levels. The
data support the notion that TNF-alpha is important in the causation of
ACD, but suggest a mechanism independent of EPO suppression. Instead,
TNF-alpha may act directly on bone marrow red cell precursors.
相似文献
1000.