全文获取类型
收费全文 | 8981篇 |
免费 | 387篇 |
国内免费 | 75篇 |
专业分类
耳鼻咽喉 | 95篇 |
儿科学 | 142篇 |
妇产科学 | 161篇 |
基础医学 | 988篇 |
口腔科学 | 196篇 |
临床医学 | 556篇 |
内科学 | 2262篇 |
皮肤病学 | 160篇 |
神经病学 | 587篇 |
特种医学 | 362篇 |
外科学 | 1805篇 |
综合类 | 22篇 |
一般理论 | 1篇 |
预防医学 | 242篇 |
眼科学 | 217篇 |
药学 | 467篇 |
中国医学 | 17篇 |
肿瘤学 | 1163篇 |
出版年
2023年 | 69篇 |
2022年 | 140篇 |
2021年 | 222篇 |
2020年 | 121篇 |
2019年 | 144篇 |
2018年 | 221篇 |
2017年 | 155篇 |
2016年 | 187篇 |
2015年 | 219篇 |
2014年 | 269篇 |
2013年 | 342篇 |
2012年 | 596篇 |
2011年 | 672篇 |
2010年 | 372篇 |
2009年 | 326篇 |
2008年 | 615篇 |
2007年 | 619篇 |
2006年 | 561篇 |
2005年 | 551篇 |
2004年 | 498篇 |
2003年 | 491篇 |
2002年 | 441篇 |
2001年 | 131篇 |
2000年 | 125篇 |
1999年 | 127篇 |
1998年 | 126篇 |
1997年 | 78篇 |
1996年 | 80篇 |
1995年 | 59篇 |
1994年 | 67篇 |
1993年 | 55篇 |
1992年 | 95篇 |
1991年 | 66篇 |
1990年 | 77篇 |
1989年 | 55篇 |
1988年 | 57篇 |
1987年 | 47篇 |
1986年 | 51篇 |
1985年 | 38篇 |
1984年 | 36篇 |
1983年 | 36篇 |
1982年 | 21篇 |
1981年 | 13篇 |
1980年 | 17篇 |
1979年 | 21篇 |
1978年 | 16篇 |
1977年 | 19篇 |
1975年 | 13篇 |
1971年 | 10篇 |
1970年 | 11篇 |
排序方式: 共有9443条查询结果,搜索用时 15 毫秒
1.
2.
An attempt was made to explore the quantitative relationship between the intestinal absorption data obtained from in vivo studies and in situ perfusion studies. The time course of the fraction remaining to be absorbed of L-glucose, erythritol, and urea in the small intestine following the intrajejunal administration to rats was described by a one-compartment model. Thus derived first-order intestinal absorption rate constants (ka) obtained from the in vivo studies in rats were compared with the membrane permeability clearances (CLa,m) estimated in a single-pass perfusion system. Not only were ka and CLa,m in the same increasing order of L-glucose less than erythritol less than urea, but also the operational luminal volumes given as CLa,m/ka were in agreement with the in vivo luminal volume of jejunum estimated by an inulin dilution method. This result suggests that the in vivo intestinal absorption rate (or ka) can be correlated with the intestinal membrane permeability (or CLa,m) by taking the in vivo luminal volume into account. 相似文献
3.
Yutaka Okishio Tadayoshi Takeuchi Akikazu Fujita Kiyotaka Suenaga Kaori Fujinami Satoru Munakata Tadashi Takewaki Fumiaki Hata 《Journal of Smooth Muscle Research》2005,41(3):163-174
Recently an essential role of interstitial cells of Cajal (ICC) within myenteric plexus (ICC-MY) was suggested in ascending contraction and descending relaxation in the mouse ileum. The role of ICC in these neural reflexes was examined in the distal colonic segments prepared from the wild type and c-kit mutant, W/W(V) mice, in the present study. Localized distension of the segments from the wild type mice by using a small balloon resulted in ascending contraction and descending relaxation. In the segments from the mutant mice, localized distension also induced these neural reflexes similar to those observed in the wild type mice. Immunohistochemical examination demonstrated that ICC-MY and ICC present in muscle layers (ICC-IM) were severely disrupted in the mutant mouse, but only ICC, present within submucosal plexus (ICC-SMP), remained unchanged. In the small strips with ICC-SMP absent prepared from the mutant mouse, electrical field stimulation induced contraction or relaxation in the absence or presence of atropine, respectively. It was suggested that ICC have no important role in the ascending and descending neural reflexes in the mouse distal colon, this is in direct contrast to the role of ICC-MY in the ileum. 相似文献
4.
Objectives To analyze the relationship between lateral displacement of the mandible and scoliosis.
Methods From April 2002 through July 2003, we examined posteroanterior cephalometric radiographs and chest X-rays from 85 patients
with jaw deformities and a control group of 20 patients with no jaw deformities. To measure the lateral shift of the mandible,
we drew a horizontal baseline (X axis) on the cephalogram connecting the intersection of the external margins of the orbits and the most lateral points of
the greater wings of the sphenoid. A vertical baseline (Y axis) was then marked perpendicular to the X axis, intersecting the ethmoid crista galli. Then, we measured the lateral displacement of the mandibular mentum from the
Y axis. Displacement to the right was designated positive; that to the left was designated negative. Cobb's method was used
to measure scoliosis curves on chest X-rays; the direction of the curve was designated similarly.
Results Of the 85 patients with jaw deformity, 23 (27.1%) had a Cobb angle exceeding 10°. None of the control group had scoliosis
exceeding 10°. No correlation was found between the direction of mandibular displacement and the direction of scoliosis.
Conclusion This study suggests a relationship between jaw deformities and scoliosis, as scoliosis was found in 27.1% of the patients
with a main complaint of jaw deformity. 相似文献
5.
Tetsuya Ozeki Shuji Beppu Takuto Mizoe Yuuki Takashima Hiroshi Yuasa Hiroaki Okada 《Journal of controlled release》2005,107(3):387-394
In this study, we used a novel 4-fluid nozzle spray drier to prepare composite microparticles of a water-insoluble drug, flurbiprofen (FP), and a water-soluble drug, sodium salicylate (SS), for the purpose of improving the water solubility of FP. An ethanol solution of FP and an aqueous SS solution were simultaneously introduced through different liquid passages in the 4-fluid nozzle spray drier and then spray-dried. Quantitative elemental analysis suggested that the FP/SS ratio in each composite microparticle was nearly the same as the formulation ratio. We also found that SS and FP exist in a low crystallinity state in the composite particles. Release of FP from dissolved composite microparticles was markedly improved because of an increase in the effective surface area following rapid dissolution of SS. This study shows that it is possible to prepare FP-SS composite microparticles using a 4-fluid nozzle spray drier in single process and that this can improve the ability of FP to dissolve in water. 相似文献
6.
Yuhei Okubo Junji Yonese Satoru Kawakami Sinya Yamamoto Yoshinobu Komai Hideki Takeshita Yuichi Ishikawa Iwao Fukui 《International journal of urology》2007,14(9):854-855
Renal cell carcinoma (RCC) causes many kinds of symptoms such as hypercalcemia, hypertension, polycythemia and fever. Here we describe a rare case of RCC presenting with a persistent cough. After radical nephrectomy, the obstinate cough disappeared. When the tumor recurred locally, the cough also recurred. Furthermore, the cough disappeared completely again after the removal of the recurrent tumor. Although all the clinical findings suggested that the RCC caused the cough, we could not identify a specific humoral substance responsible for the cough. 相似文献
7.
Mizuaki Sakura Satoru Kawakami Hitoshi Masuda Tsuyoshi Kobayashi Yukio Kageyama Kazunori Kihara 《International journal of urology》2007,14(12):1109-1112
Since 1998, we have performed minimum incision endoscopic surgery (MIES) for renal cell carcinoma (RCC). For seven dialysis patients with bilateral RCC, we have performed sequential bilateral MIES radical nephrectomy. It was carried out by retroperitoneal approach through a single minimum incision that narrowly permitted extraction of the specimen using endoscopy and direct stereovision, without trocar ports, without gas insufflation and without the insertion of the hands of operators into the operative field. Although six of the seven patients had multiple complications in addition to chronic renal failure (CRF), bilateral kidneys were successfully removed by sequential MIES radical nephrectomy without major operative complication. Postoperative recovery was prompt with all patients resuming oral feeding and walking by the second postoperative day. Sequential bilateral MIES radical nephrectomy, leaving the peritoneal cavity intact and without imposing circulatory stress caused by gas insufflation, is a feasible treatment for bilateral RCCs in dialysis patients. 相似文献
8.
9.
Toyohiro Kagawa Fumiko Fukunari Tomoko Shiraishi Miwako Yamasaki Takahiro Ichihara Yuka Kihara Ryousuke Zeze Kentaro Nogami Kenji Yuasa 《Oral Radiology》2006,22(2):47-51
Objectives To develop a simple image viewer that utilizes image files in general-purpose formats that are written from the original 3DX
volume data.
Methods We used FLASH MX2004 for Macintosh to develop a simple image viewer. In developing the software for the simple image viewer,
we decided that the viewer should provide the following features: (1) be available to both Windows OS and Mac OS, (2) allow
interlocking of the 3D images, (3) display image enlargement, and (4) allow distance measurements. The accuracy of the distance
measurements was evaluated.
Results The procedure was as follows: (1) write 3D images in jpeg format to a folder on i-VIEW; (2) place the folder containing the
3D images into the directory of the simple image viewer software on a PC; (3) start the software and open the window to input
the folder name containing the 3D images; and (4) display the 3D images. Our viewer had features such as image enlargement,
interlocking 3D images, drawing, and distance measurements. No significant differences were shown between the measurements
made by our simple viewer and the actual values of the images in any direction.
Conclusions Our image-viewing software for 3DX is beneficial for clinical use. 相似文献
10.
Yutaka Ejima Yoko Hasegawa Satoru Sanada Noriyuki Miyama Ryo Hatano Tomohiro Arata Michiko Suzuki Itsuro Kazama Akira Sato Susumu Satomi Wataru Hida Mitsunobu Matsubara 《Hypertension research》2006,29(4):261-267
Since the prevalence and clinical characteristics of young-onset hypertension are still to be elucidated, we performed targeted-screening at an annual university health check-up for two consecutive years. Out of 16,464 subjects in 2003 and 17,032 in 2004 that were aged less than 30 years, 22 and 26 students (all males) exhibited high blood pressure (BP), respectively, on three occasions during casual BP measurements at the Tohoku University Health Center (systolic and diastolic BP of 140 and/or 90 mmHg or greater, respectively). These students were asked to measure their BP at home, and 9 subjects in total were diagnosed as having essential hypertension (EH). The remaining students were diagnosed as having white coat hypertension (WCH). In 8 out of 9 EH students, their father and/or mother had also been treated with antihypertensive medication. Adjustment by attendance ratio for each BP measurement suggested that the incidence of EH was around 0.1% and that of hypertension (EH and WCH) was around 0.5% in university students aged less than 25 years, since most of the subjects and hypertensive students were between 18 and 24 years old. Body mass index of the EH, which was more than 25 kg/m2 (overweight), was significantly higher than that with WCH. In conclusion, the combination of repeated casual BP measurements and home BP effectively identified young-onset EH. The clinical parameters indicated that male gender, genetic background, and excessive weight were risk factors for young-onset hypertension. 相似文献