全文获取类型
收费全文 | 4117篇 |
免费 | 220篇 |
国内免费 | 21篇 |
专业分类
耳鼻咽喉 | 77篇 |
儿科学 | 236篇 |
妇产科学 | 21篇 |
基础医学 | 317篇 |
口腔科学 | 49篇 |
临床医学 | 351篇 |
内科学 | 1170篇 |
皮肤病学 | 53篇 |
神经病学 | 311篇 |
特种医学 | 134篇 |
外科学 | 687篇 |
综合类 | 84篇 |
一般理论 | 1篇 |
预防医学 | 113篇 |
眼科学 | 205篇 |
药学 | 297篇 |
中国医学 | 10篇 |
肿瘤学 | 242篇 |
出版年
2024年 | 2篇 |
2023年 | 52篇 |
2022年 | 89篇 |
2021年 | 228篇 |
2020年 | 76篇 |
2019年 | 139篇 |
2018年 | 219篇 |
2017年 | 119篇 |
2016年 | 136篇 |
2015年 | 122篇 |
2014年 | 211篇 |
2013年 | 282篇 |
2012年 | 398篇 |
2011年 | 393篇 |
2010年 | 200篇 |
2009年 | 152篇 |
2008年 | 241篇 |
2007年 | 281篇 |
2006年 | 265篇 |
2005年 | 208篇 |
2004年 | 173篇 |
2003年 | 135篇 |
2002年 | 117篇 |
2001年 | 17篇 |
2000年 | 19篇 |
1999年 | 13篇 |
1998年 | 17篇 |
1997年 | 11篇 |
1996年 | 10篇 |
1995年 | 15篇 |
1994年 | 2篇 |
1993年 | 3篇 |
1992年 | 3篇 |
1991年 | 3篇 |
1990年 | 2篇 |
1989年 | 2篇 |
1988年 | 1篇 |
1984年 | 1篇 |
1981年 | 1篇 |
排序方式: 共有4358条查询结果,搜索用时 15 毫秒
71.
Nils Henninger Diogo C. Haussen Nikolaos Kakouros Magdy Selim D. Eric Searls Sandeep Kumar Gottfried Schlaug Louis R. Caplan 《Neurocritical care》2013,19(2):167-175
Background and Purpose
To evaluate the relationship between infarct location and QTc-prolongation in patients with posterior circulation strokes.Methods
Admission electrocardiograms (ECG) of 131 patients among a prospective sample of 407 consecutive adult patients in the New England Medical Center Posterior Circulation Registry were retrospectively analyzed. The QT interval (ms) was measured and corrected using Bazett’s formula (QTcBazett) as well as linear regression functions (QTcLinear). QTcBazett > 440 ms and QTcLinear ≥ 450 ms for men (≥460 ms for women) were considered prolonged. Multivariable linear and logistic regression analyses were used to identify independent predictors of the QTc.Results
Overall, 34 % of patients had a prolonged QTcBazett and 7 % had a prolonged QTcLinear noted on the admission ECG. There was a significant association between temporal lobe infarction and QTcBazett and QTcLinear (p < 0.001 for both) in multivariable linear regression analyses adjusting for demographics, ECG parameters, and preadmission medication use. In multivariable logistic regression analysis, temporal lobe infarction emerged as an independent predictor of prolonged QTcBazett (p = 0.009) and QTcLinear (p = 0.008), respectively. Sensitivity analyses excluding patients with transient ischemic attack yielded similar results. Exploratory analyses indicated that patients with temporal lobe infarction had worse functional 30-day outcomes in multivariable logistic regression (p = 0.022). However, there was no significant association between QTc and 30-day functional outcome.Conclusions
QTc-prolongation is common after posterior circulation stroke and associated with temporal lobe infarction. Prospective studies are needed to confirm these preliminary findings and to examine potential long-term consequences. 相似文献72.
73.
74.
Although the concept of extracorporeal membrane oxygenation (ECMO) has remained unchanged, component technology has evolved considerably over the past three decades. Presently the clinical conditions requiring ECMO support have been updated with input from the outcome data of patient registries. Modern circuit configuration has become less cumbersome, safer, and more efficient. Technological advances now allow prolonged support with fewer complications compared to the past eras and facilitate transition to a single bedside caregiver model, similar to hemofiltration or ventricular-assist devices. The clinical considerations and indicators for placing the patient on ECMO, the various circuit configurations, clinical and technical issues, and management aspects are considered in this article. 相似文献
75.
76.
77.
78.
Sridevi Nair Murugesan Vanathi Ritika Mukhija Radhika Tandon Sandeep Jain Yoko Ogawa 《Indian journal of ophthalmology》2021,69(5):1038
Ocular graft-versus-host disease (oGVHD) occurs as a complication following hematopoietic stem cell transplantation and is associated with significant ocular morbidity resulting in a marked reduction in the quality of life. With no current consensus on treatment protocols, management becomes challenging as recurrent oGVHD often refractory to conventional treatment. Most authors now diagnose and grade the disease based on criteria provided by the National Institutes of Health Consensus Conference (NIH CC) or the International Chronic oGVHD (ICCGVHD) consensus group. This article will provide an insight into the diagnostic criteria of oGVHD, its classification, and clinical severity grading scales. The inflammatory process in oGVHD can involve the entire ocular surface including the eyelids, meibomian gland, corneal, conjunctiva, and lacrimal system. The varied clinical presentations and treatment strategies employed to manage them have been discussed in the present study. The recent advances in ocular surface imaging in oGVHD patients such as the use of meibography and in vivo confocal microscopy may help in early diagnosis and prognostication of the disease. Researching tear proteomics and identification of novel potential tear biomarkers in oGVHD patients is an exciting field as they may help in objectively diagnosing the disease and monitoring the response to treatment. 相似文献
79.
80.
Jyoti Korram Lakshita Dewangan Indrapal Karbhal Rekha Nagwanshi Sandeep K. Vaishanav Kallol K. Ghosh Manmohan L. Satnami 《RSC advances》2020,10(41):24190
An enzyme immobilized glutathione (GSH)-capped CdTe quantum dot (QD)-based fluorescence assay has been developed for monitoring organophosphate pesticides. In principle, GSH-capped CdTe QDs exhibit higher sensitivity towards H2O2 produced from the active enzymatic reaction of acetylcholinesterase (AChE) and choline oxidase (CHOx), which results in the fluorescence (FL) “turn-off” of the GSH-capped CdTe QDs. A “turn-on” FL of the CdTe QDs at 520 nm was recovered in the presence of organophosphate (OP). The FL changes of the GSH-capped CdTe QD/AChE/CHOx biosensor reasonably correspond to the amount of OP pesticides. The detection limit of the CdTe/AChE/CHOx biosensor towards paraoxon, dichlorvos, malathion and triazophos was 1.62 × 10−15 M, 75.3 × 10−15 M, 0.23 × 10−9 M and 10.6 × 10−12 M, respectively. The GSH-capped CdTe QDs/AChE/CHOx biosensor was applied as a FL nanoprobe for assaying the enzymatic activity of AChE. The inhibited AChE was reactivated up to 94% using pyridine oximate (2-PyOx−), and functionalized pyridinium oximates (4-C12PyOx− and 4-C18PyOx−) of varying chain lengths. It was found that the reactivation potency of the tested oximes varied with the chain length of the oximes. This biosensing system offers the promising benefit for the determination of the OP pesticides in food, water and environmental samples.An enzyme immobilized glutathione (GSH)-capped CdTe quantum dot (QD)-based fluorescence assay has been developed for monitoring organophosphate pesticides. 相似文献