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971.
972.
Ektor Tsuneo Onishi Cláudia Couto de Barros Coelho Jeanne Oiticica Ricardo Rodrigues Figueiredo Rita de Cassia Cassou Guimarães Tanit Ganz Sanchez Adriana Lima Gürtler Alessandra Ramos Venosa André Luiz Lopes Sampaio Andreia Aparecida Azevedo Anna Paula Batista de Ávila Pires Bruno Borges de Carvalho Barros Carlos Augusto Costa Pires de Oliveira Clarice Saba Fernando Kaoru Yonamine Ítalo Roberto Torres de Medeiros Letícia Petersen Schmidt Rosito Marcelo José Abras Rates Sandro de Menezes Santos Torres 《Revista brasileira de otorrinolaringologia (English ed.)》2018,84(2):135-149
Introduction
Tinnitus and sound intolerance are frequent and subjective complaints that may have an impact on a patient's quality of life.Objective
To present a review of the salient points including concepts, pathophysiology, diagnosis and approach of the patient with tinnitus and sensitivity to sounds.Methods
Literature review with bibliographic survey in LILACS, SciELO, Pubmed and MEDLINE database. Articles and book chapters on tinnitus and sound sensitivity were selected. The several topics were discussed by a group of Brazilian professionals and the conclusions were described.Results
The prevalence of tinnitus has increased over the years, often associated with hearing loss, metabolic factors and inadequate diet. Medical evaluation should be performed carefully to guide the request of subsidiary exams. Currently available treatments range from medications to the use of sounds with specific characteristics and meditation techniques, with variable results.Conclusion
A review on tinnitus and auditory sensitivity was presented, allowing the reader a broad view of the approach to these patients, based on scientific evidence and national experience. 相似文献973.
Guillermo V. Sanchez Caitlin Biedron Lauren R. Fink Kelly M. Hatfield Jordan Micah F. Polistico Monica P. Meyer Rebecca S. Noe Casey E. Copen Amanda K. Lyons Gonzalo Gonzalez Keith Kiama Mark Lebednick Bonnie K. Czander Amen Agbonze Aimee R. Surma Avnish Sandhu Valerie H. Mika Tyler Prentiss John Zervos Donia A. Dalal Amber M. Vasquez Sujan C. Reddy John Jernigan Paul E. Kilgore Marcus J. Zervos Teena Chopra Carla P. Bezold Najibah K. Rehman 《MMWR. Morbidity and mortality weekly report》2020,69(27):882
974.
975.
Zaima Mazorra Lisset Chao Anabel Lavastida Belinda Sanchez Mayra Ramos Normando Iznaga Tania Crombet 《Seminars in oncology》2018,45(1-2):18-26
One of the most known oncogenes is the epidermal growth factor receptor (EGFR) family. It activates multiple signaling cascades that promote carcinogenesis and immune evasion. Therefore, these molecules have been extensively targeted in cancer immunotherapy. Beyond EGFR signaling cascade inhibition, some of these agents are able to induce T-cell activation, transforming a passive therapy into a vaccine-like effect. Nimotuzumab is an IgG1 humanized monoclonal antibody directed against the extracellular domain of the EGFR blocking the binding to its ligands. It possesses unique pharmacodynamic properties, which allow treating patients for long-term periods and with very low toxicity. Based on its clinical effect, nimotuzumab has been approved in Cuba and abroad for the treatment of different epithelial tumors. Recently, new potential mechanisms of action of nimotuzumab involving the activation of the innate and adaptive immune response have been reported. This review summarizes the main properties of nimotuzumab in comparison with other EGFR-specific monoclonal antibodies, highlighting its capacity to activate an effective immune response. In addition, differential clinical effects of this antibody and ongoing clinical trials to deeply characterize the biomarkers of clinical benefit are shown. 相似文献
976.
Balbani AP Sanchez TG Butugan O Kii MA Angélico FV Ikino CM D'Antonio WE 《International journal of pediatric otorhinolaryngology》1998,46(1-2):37-42
The removal of foreign bodies in children is very common in the otolaryngologist's daily routine. We present a prospective series of 187 cases of ear and nose foreign bodies removed from children aged 0-12 years old in a 6-month period--95 females (50.8%) and 92 males (49.2%); 78 children (41.71%) aged from 1 to 2 years, 66 (35.29%) from 3 to 5 years. There were 93 cases (49.73%) of ear foreign bodies, in which a bean was the most common (24.73%), and 94 cases (50.27%) of nose foreign bodies, in which sponge fragments predominated (36.17%). In 82 cases (45.85%), the removal was performed within the first 24 h after the foreign body insertion, and 86 (45.98%) of the patients had previous attempts to remove it. Thirteen cases with complications (external ear canal lacerations, tympanic membrane perforation) were observed in patients in whom these previous attempts had been made, but there were no sequelae. This corresponds to one of the largest reports of ear and nose foreign body removal in children in the literature; we conclude that younger children are more prone to insert foreign bodies, which are objects usually found at home. Complications may occur as a result of attempts to remove the foreign body without the help of specialised personnel or proper conditions. 相似文献
977.
Sanchez MN Barker C Brosnan J 《Dermatology nursing / Dermatology Nurses' Association》1998,10(6):419-23, 429
As the prophylactic use of heparin continues to increase, nurses must be aware that heparin use may cause heparin-induced skin necrosis--a rare but serious complication. Although even more severe complications may occur from heparin use, this discussion will focus on skin necrosis caused by subcutaneous heparin. Should heparin-induced skin necrosis develop, heparin therapy must be discontinued immediately. This case presentation illustrates one patient's reaction to this complication. 相似文献
978.
Drebot MA Gavrilovskaya I Mackow ER Chen Z Lindsay R Sanchez AJ Nichol ST Artsob H 《Virus research》2001,75(1):75-86
In Canada, hantavirus infected deer mice (Peromyscus maniculatus) have been collected from British Columbia to Newfoundland. Partial sequencing of G1 and N protein encoding regions from Canadian Peromyscus maniculatus-borne hantaviruses demonstrated the existence of significant genotypic divergence among strains. Phylogenetic analysis showed that Sin Nombre (SN)-like viruses from eastern and western Canadian deer mice can be divided into at least two broad-based genogroups. Sequencing of mitochondrial DNA from infected deer mice originating from various eastern and western provinces showed that SN-like virus genogroups appeared to be associated with distinct haplotypes of mice. Sera from deer mice infected with eastern and western viral genotypes neutralized the Sin Nombre virus strain, Convict Creek 107, but not the New York 1 hantavirus. Despite the genetic heterogeneity of Canadian SN-like strains these hantaviruses do not appear to define unique hantavirus serotypes. 相似文献
979.
Gabrieli R Sanchez G Macaluso A Cenko F Bino S Palombi L Buonomo E Pinto RM Bosch A Divizia M 《Journal of medical virology》2004,72(4):533-537
Hepatitis A is a common disease in developing countries and Albania has a high prevalence of this disease associated to young age. In spite of the occurrence of a unique serotype there are different genotypes classified from I to VII. Genotype characterisation of HAV isolates circulating in Albania has been undertaken, as well as the study of the occurrence of antigenic variants in the proteins VP3 and VP1. To evaluate the genetic variability of the Albanian hepatitis A virus (HAV) isolates, samples were collected from 12 different cities, and the VP1/2A junction amplified and sequenced. These sequences were aligned and a phylogenetic analysis performed. Additionally, the amino half sequence of the protein VP3 and the complete sequence of the VP1 was determined. Anti-HAV IgM were present in 66.2% of all the sera. Fifty HAV isolates were amplified and the analysis revealed that all the isolates were sub-genotype IA with only limited mutations. When the deduced amino acid sequences were obtained, the alignment showed only two amino acids substitutions at positions 22 and 34 of the 2A protein. A higher genomic stability of the VP1/2A region, in contrast with what occurs in other parts of the world could be observed, indicating high endemicity of HAV in Albania. In addition, two potential antigenic variants were detected. The first at position 46 of VP3 in seven isolates and the second at position 23 of VP1 in six isolates. 相似文献
980.
A Armentia J Tapias D Barber J Martin R de la Fuente P Sanchez G Salcedo J Carreira 《Annals of allergy》1992,68(5):398-403
Occupational allergy due to hypersensitivity to cereal flours is relatively common among bakers and grain-store workers. Storage mites can contaminate wheat flour and could be an important cause of allergic symptoms due to inhalation. Forty-three patients with criteria for allergic sensitization to wheat flour (skin tests, specific IgE to wheat flour and positive challenge tests) were included in a study to investigate the prevalence of cosensitization to Lepidoglyphus destructor (Ld). This mite was the predominant species in the wheat flour samples supplied by our patients. We found that 30% of the patients had IgE-mediated hypersensitivity of Ld. Of these, 23% did not have a relationship with any bakery or agriculture. We conclude that the prevalence of sensitization to Ld in patients sensitized to wheat flour is important. 相似文献