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61.
Localization of the tandem pore domain K+ channel TASK-1 in the rat central nervous system 总被引:3,自引:0,他引:3
Kindler CH Pietruck C Yost CS Sampson ER Gray AT 《Brain research. Molecular brain research》2000,80(1):99-108
Recently, a new family of potassium channels with two pore domains in tandem and four transmembrane segments has been identified. Seven functional mammalian channels have been reported at this time. These channels give rise to baseline potassium currents because they are not gated by voltage and exhibit spontaneous activity at all membrane potentials. Although the physiological role of these ion channels has yet to be determined, three mammalian members of this family (TREK-1, TASK-1, TASK-2) are activated by volatile anesthetics and may therefore contribute to the central nervous system (CNS) depression produced by volatile anesthetics. In this study we used northern blot analysis and immunohistochemical localization to determine the expression of TASK-1 subunits in the CNS. TASK-1 immunoreactivity was prominently found in astrocytes of the hippocampus, in the median eminence, in the choroid plexus, and the granular layer, Purkinje cell layer, and molecular layer of the cerebellum. In the spinal cord, strong TASK-I immunoreactivity was seen in ependymal cells lining the central canal and in white matter. These findings suggest a role for the TASK-1 channel in the production of cerebrospinal fluid and function of hypothalamic neurosecretory cells. 相似文献
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Michael Weller Nicholas Butowski David D Tran Lawrence D Recht Michael Lim Hal Hirte Lynn Ashby Laszlo Mechtler Samuel A Goldlust Fabio Iwamoto Jan Drappatz Donald M ORourke Mark Wong Mark G Hamilton Gaetano Finocchiaro James Perry Wolfgang Wick Jennifer Green John H Sampson 《The lancet oncology》2017,18(12):e709-e710
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Ayaka Motomura Yuki Nakaya Clarence Sampson Takuma Higo Maki Torimoto Hideaki Tsuneki Shinya Furukawa Yasushi Sekine 《RSC advances》2022,12(44):28359
Dry reforming of methane (DRM) is a promising reaction able to convert greenhouse gases (CO2 and CH4) into syngas: an important chemical feedstock. Several difficulties limit the applicability of DRM in conventional thermal catalytic reactions; it is an endothermic reaction that requires high temperatures, resulting in high carbon deposition and a low H2/CO ratio. Catalysis with the application of an electric field (EF) at low temperatures can resolve these difficulties. Synergistic effects with alloys have also been reported for reactions promoted by the application of EF. Therefore, the synergistic effects of low-temperature DRM and Ni–Fe bimetallic catalysts were investigated using various methods and several characterisations (XRD, XPS, FE-STEM, etc.), which revealed that Ni–Fe binary catalysts show high performance in low-temperature DRM. In particular, the Ni0.8Fe0.2 catalyst supported on CeO2 was found to carry out DRM in EF effectively and selectively by virtue of its bimetallic characteristics.Dry reforming of methane (DRM) is a promising reaction able to convert greenhouse gases (CO2 and CH4) into syngas: an important chemical feedstock. 相似文献
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王虹峥 《中国中医基础医学杂志》1999,(1):30-34
花生过敏是造成人IgE诱导中毒反应的主要原因之一,本试验组制作C3H小鼠动物模型,并给其口服花生蛋白(PN)及霍乱毒素(CTx),然后在腹腔内注射PN(溶于明矾中的PN),使这种鼠即刻发生高度敏感症状(包括致死性的中毒反应)及花生特异性IgE水平增高,血浆息斯地明水平、脱颗粒肥大细胞及血管渗漏水平也大幅度升高。对照组小鼠未给药或仅仅接受了CTx,则未显示出花生特异性IgE水平升高及中毒症状。本文又分析了几种与中毒反应有关的参数。结果证明,小鼠花生过敏中毒反应与人花生过敏类似,同时小鼠花生过敏中毒反应模型,为研究中毒性免疫病理发生机制及研究更有效的治疗方案提供了一个有用的工具。 相似文献
66.
氯地滴眼液的含量测定 总被引:4,自引:0,他引:4
目的:采用HPLC法测定氯地滴眼液中氯霉素和地塞米松磷酸钠的含量。方法:色谱分析条件:ODS柱作分析柱,流动相为甲醇/水体系,0 ̄8min使用40%甲醇,8 ̄16min使用60%甲醇,流速1ml/min,0 ̄9min240nm紫外检测,:二组分分离良好。各组各组性关系良好,平均回收率氯霉素99.8%(RSD=1.2%,n=5),地塞米松磷酸钠99.4%(RSD=0.7%,n=5),结论:该法用于氯 相似文献
67.
Singapore Indian Eye Study‐2: methodology and impact of migration on systemic and eye outcomes 下载免费PDF全文
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Tolbert G. Nyenswah Mosaka Fallah Geoffrey M. Calvert Stanley Duwor E. Dutch Hamilton Vishwesh Mokashi Sampson Arzoaquoi Emmanuel Dweh Ryan Burbach Diane Dlouhy John E. Oeltmann Patrick K. Moonan 《Emerging infectious diseases》2015,21(7):1253-1256
Lack of trust in government-supported services after the death of a health care worker with symptoms of Ebola resulted in ongoing Ebola transmission in 2 Liberia counties. Ebola transmission was facilitated by attempts to avoid cremation of the deceased patient and delays in identifying and monitoring contacts. 相似文献