全文获取类型
收费全文 | 738篇 |
免费 | 28篇 |
国内免费 | 47篇 |
专业分类
耳鼻咽喉 | 2篇 |
儿科学 | 39篇 |
妇产科学 | 3篇 |
基础医学 | 61篇 |
口腔科学 | 11篇 |
临床医学 | 96篇 |
内科学 | 212篇 |
皮肤病学 | 20篇 |
神经病学 | 75篇 |
特种医学 | 144篇 |
外科学 | 24篇 |
综合类 | 24篇 |
预防医学 | 9篇 |
眼科学 | 5篇 |
药学 | 55篇 |
中国医学 | 3篇 |
肿瘤学 | 30篇 |
出版年
2023年 | 2篇 |
2021年 | 4篇 |
2020年 | 4篇 |
2019年 | 2篇 |
2018年 | 5篇 |
2017年 | 7篇 |
2016年 | 6篇 |
2015年 | 22篇 |
2014年 | 18篇 |
2013年 | 22篇 |
2012年 | 9篇 |
2011年 | 10篇 |
2010年 | 31篇 |
2009年 | 27篇 |
2008年 | 14篇 |
2007年 | 54篇 |
2006年 | 18篇 |
2005年 | 14篇 |
2004年 | 13篇 |
2003年 | 5篇 |
2002年 | 18篇 |
2001年 | 19篇 |
2000年 | 7篇 |
1999年 | 13篇 |
1998年 | 45篇 |
1997年 | 47篇 |
1996年 | 56篇 |
1995年 | 31篇 |
1994年 | 32篇 |
1993年 | 20篇 |
1992年 | 10篇 |
1991年 | 11篇 |
1990年 | 8篇 |
1989年 | 33篇 |
1988年 | 27篇 |
1987年 | 21篇 |
1986年 | 21篇 |
1985年 | 15篇 |
1984年 | 14篇 |
1983年 | 6篇 |
1982年 | 15篇 |
1981年 | 11篇 |
1980年 | 14篇 |
1979年 | 4篇 |
1978年 | 5篇 |
1977年 | 5篇 |
1976年 | 6篇 |
1975年 | 7篇 |
1931年 | 1篇 |
1925年 | 1篇 |
排序方式: 共有813条查询结果,搜索用时 0 毫秒
811.
Human immunodeficiency virus-type 1 replication can be increased in peripheral blood of seropositive patients after influenza vaccination 总被引:18,自引:0,他引:18
O'Brien WA; Grovit-Ferbas K; Namazi A; Ovcak-Derzic S; Wang HJ; Park J; Yeramian C; Mao SH; Zack JA 《Blood》1995,86(3):1082-1089
Despite considerable evidence that cell activation enhances human immunodeficiency virus-type 1 (HIV-1) replication in vitro, there is very little data on the role of immune activation on in vivo HIV-1 replication. In this study, we examined the effect of influenza vaccination on HIV-1 replication in the peripheral blood of 20 study subjects, and in 14 control subjects who did not receive influenza vaccination. Blood was obtained from each subject on three occasions during the month before vaccination and again on three occasions during the following month. Over the study period, there was little change in levels of proviral DNA in peripheral blood mononuclear cells (PBMCs). However, peak PBMC viral RNA levels after influenza vaccination were significantly increased over the mean of prevaccination values. This change was not observed to the same extent in unvaccinated controls. Therefore, this is the first report showing that HIV-1 replication can increase in temporal association with influenza vaccination. Our results suggest that continued immunologic (antigenic) stimulation may result in increased virus load in vivo. To address the appropriateness of influenza vaccination in HIV-infected patients, expanded studies will be required to examine specific and generalized immune responses to vaccination, and differences in patient response based on disease stage. 相似文献
812.
Combined surgical and radiologic intervention for complicated cholelithiasis in high-risk patients 总被引:2,自引:0,他引:2
Gibney RG; Fache JS; Becker CD; Nichols DM; Cooperberg PL; Stoller JL; Burhenne HJ 《Radiology》1987,165(3):715-719
Ultrasound-guided surgical cholecystostomy with local infiltration anesthesia was combined with radiologic removal of gallstones in 36 elderly patients with acute calculous gallbladder disease who were considered to be at high risk due to multiple coexisting diseases. At cholecystostomy, the fundus of the gallbladder was sutured to the anterior abdominal wall resulting in a short surgical track to the gallbladder. This permitted early percutaneous stone removal through the cholecystostomy track under fluoroscopic guidance. All gallstones were removed in 31 of 36 patients, for an overall success rate of 86%. The success rate was 97% for gallbladder stones, 86% for cystic duct stones, and 63% for common bile duct stones that were removed by traversing the cystic duct. The treatment in the five patients in whom radiologic stone removal was incomplete or unsuccessful consisted of elective cholecystectomy in three, with common bile duct exploration in two of these; endoscopic sphincterotomy and stone extraction in one; and expectant management in one. There were no deaths or serious complications. This technique has thus proved safe and effective in these 36 high-risk patients. 相似文献
813.