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目的:分析不同产地仙茅药材的化学成分并测定其中仙茅苷的含量。方法:以醋酸乙酯-甲醇-甲酸(10:1:0.1)为展开剂,2%三氯化铁-2%铁氰化钾(1:1)为显色剂,对各地产仙茅药材化学成分比较分析;以薄层层析-紫外分光光度法测定仙茅苷含量。结果:各地产仙茅药材均含有仙茅苷,但其它化学成分不尽相同;含量为:1.52g‰(四川宜宾)、0.65‰(云南大关)、0.42‰(湖献溆浦)、1.39‰(广东)、0.57‰(广西)、0.24‰(贵州凯里)。结论:各地产仙茅药材化学成分不尽相同;仙茅苷含量以四川宜宾产为最高。 相似文献
185.
Esther Zeinstra Nadine Wilczak Daniel Chesik Lisa Glazenburg Frans GM Kroese Jacques De Keyser 《Journal of neuroinflammation》2006,3(1):16-4
Based on their potent anti-inflammatory properties and a preliminary clinical trial, statins (HMG-CoA reductase inhibitors)
are being studied as possible candidates for multiple sclerosis (MS) therapy. The pathogenesis of MS is unclear. One theory
suggests that the development of autoimmune lesions in the central nervous system may be due to a failure of endogenous inhibitory
control of MHC class II expression on astrocytes, allowing these cells to adapt an interferon (IFN)-γ-induced antigen presenting
phenotype. By using immunocytochemistry in cultured astrocytes derived from newborn Wistar rats we found that simvastatin
at nanomolar concentrations inhibited, in a dose-response fashion, up to 70% of IFN-γ-induced MHC class II expression. This
effect was reversed by the HMG-CoA reductase product mevalonate. Suppression of the antigen presenting function of astrocytes
might contribute to the beneficial effects of statins in MS. 相似文献
186.
Tanja T Menckeberg Svetlana V Belitser Marcel L Bouvy Madelon Bracke Jan-Willem J Lammers Jan AM Raaijmakers Hubert GM Leufkens 《BMC health services research》2007,7(1):106
Background
In order to accurately distinguish gaps of varying length in drug treatment for chronic conditions from discontinuation without resuming therapy, short-term observation does not suffice. Thus, the use of inhalation corticosteroids (ICS) in the long-term, during a ten-year period is investigated. To describe medication use as a continuum, taking into account the timeliness and consistency of refilling, a Markov model is proposed. 相似文献187.
188.
Navin R Bindraban Irene GM van Valkengoed Gideon Mairuhu Frits Holleman Joost BL Hoekstra Bob PJ Michels Richard P Koopmans Karien Stronks 《BMC public health》2008,8(1):271
Background
While the prevalence of type 2 diabetes mellitus (DM) is high, tailored risk scores for screening among South Asian and African origin populations are lacking. The aim of this study was, first, to compare the prevalence of (known and newly detected) DM among Hindustani Surinamese, African Surinamese and ethnic Dutch (Dutch). Second, to develop a new risk score for DM. Third, to evaluate the performance of the risk score and to compare it to criteria derived from current guidelines. 相似文献189.
Suzanne GM Stomp-van den Berg Mireille NM van Poppel Ingrid JM Hendriksen David J Bruinvels Kimi Uegaki Martine C de Bruijne Willem van Mechelen 《BMC public health》2007,7(1):43
Background
Many women suffer from health problems after giving birth, which can lead to sick leave. About 30% of Dutch workers are on sick leave after maternity leave. Structural contact of supervisors with employees on maternity leave, supported by early medical advice of occupational physicians, may increase the chances of return-to-work after maternity leave. In addition, to understand the process of sick leave and return-to-work after childbirth it is important to gain insight into which factors hinder return-to-work after childbirth, as well, as which prognostic factors lead to the development of postpartum health complaints. In this paper, the design of the Mom@Work study is described. 相似文献190.
Jaap?J?Brunnekreef Caro?JT?van UdenEmail author Steven?van Moorsel Jan?GM?Kooloos 《BMC musculoskeletal disorders》2005,6(1):17