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排序方式: 共有138条查询结果,搜索用时 15 毫秒
21.
Maryam Hakimi Parizi Iraj Sharifi Saeedeh Farajzadeh Abbas Pardakhty Mohammad Hossein Daie Parizi Hamid Sharifi Ali Reza Keyhani Mahshid Mostafavi Mehdi Bamorovat Ahmad Khosravi Daryoush Ghaffari 《Asian Pacific journal of tropical medicine》2019,(8)
Objective: To explore the antileishmanial effect of tioxolone and its niosomal form against Leishmania tropica. Methods: Tioxolone niosomes were prepared by the hydration method and were evaluated for morphology, size, release study, and encapsulation efficiency. The cytotoxicity of tioxolone and its niosomal form was measured by MTT assay, leishmanicidal activity against promastigote and amastigote by MTT assay, apoptosis by flow cytometry, IL-12, IL-10 and metacaspase gene expression levels by q-PCR. Results: Span/Tween 40 and Span/Tween 60 niosomes had good physical stability as depicted in their size distribution curves and high encapsulation efficiency(99%). The release profile of the entrapped compounds showed Fickian's model of tioxolone delivery based on diffusion through lipid bilayers. With the IC50 value for amastigote as(24.5±2.1) μg/mL and selectivity index as 10.5, the Span/Tween 60 niosome(NT2) had a superior effect to other drugs. The CC50 value and IC50 of promastigote value for NT2 were(257.5±24.5) μg/mL and(164.8±20.6) μg/mL, respectively. The flow cytometric analysis showed that tioxolone and niosomal forms induced apoptosis of Leishmania tropica promastigotes in a dose-dependent manner. NT2 increased the expression level of IL-12 and metacaspase genes and decreased the expression level of the IL-10 gene.Conclusions: Niosomes of tioxolone play an immunomodulatory role in increasing Th1 cytokine profile and inhibiting the Th2 cytokine profile. It could be used for treatment of anthroponotic cutaneous leishmaniasis. 相似文献
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Babaei-Ghazani Arash Najarzadeh Saeedeh Mansoori Korosh Forogh Bijan Madani Seyed Pezhman Ebadi Safoora Fadavi Hamid Reza Eftekharsadat Bina 《Clinical rheumatology》2018,37(9):2517-2527
Clinical Rheumatology - Osteoarthritis (OA) is a chronic multifactorial disease characterized by progressive joint degeneration. The purpose of this study was to compare the effects of... 相似文献
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Salimi S Naghavi A Mokhtari M Noora M Yaghmaei M 《Archives of gynecology and obstetrics》2012,285(2):405-409
Purpose
Preeclampsia is an important disorder of pregnancy that carries a severe morbidity and mortality risk for both mother and fetus. A large number of studies have shown that abnormalities in nitric oxide synthesis may contribute to the development of preeclampsia. 相似文献27.
Objective To evaluate the in vitro effects of chichorium intybus on bilirubin levels.
Methods In this study the bilirubin levels in the serum of thirty neonates staying in the NICU and suffering from clinical jaundice
was determined three times: first without any alterations, second after adding chichorium intybus extract and third after
adding the same amount of distilled water. The results were compared using SPSS statistical software.
Results Of the patients evaluated 76.7% were male and 23.3% were female. The average age was 7.35 days. The mean difference observed
in unconjugated bilirubin levels in the specimens containing chichorium intybus extract was 3.84 ± 2.38 mg/dl and in the ones
containing distilled water was 2.85 ± 2.00 mg/dl. The mean difference observed in conjugated bilirubin levels was 0.29 ± 0.32
mg/dl in specimens containing distilled water and 0.35 ± 0.26 in the ones containing chichorium intybus. In none of the cases
the results were found to be significant.
Conclusion In this study chichorium intybus was found to have no significant in vitro effect on the bilirubin level reported by the laboratory.
The in vivo effects of this herbal medicine must be evaluated more closely. 相似文献
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Saeedeh Salimi Farzaneh Farajian-Mashhadi Ehsan Tabatabaei Mahnaz Shahrakipour Minoo Yaghmaei 《Clinical and experimental hypertension (New York, N.Y. : 1993)》2017,39(3):220-224
Purpose: Estrogen receptor-α (ERα) plays an essential role in the adaptation of increased uterine blood flow during gestation. Therefore, ERα gene could be a possible candidate for preeclampsia (PE) susceptibility. In current study we aimed to investigate the association of the ERα gene polymorphisms and PE in an Iranian population. Methods: A total of 192 pregnant women with PE and 186 normotensive women were genotyped for ERα gene (PvuII and XbaI) polymorphisms by polymerase chain reaction-restriction fragment length polymorphism method. Results: The frequencies of alleles and genotypes of ERα PvuII and XbaI polymorphisms were not different between PE and normotensive control women. However, higher frequency of GG genotype was observed in women with severe PE compared to mild PE (OR, 1.8 [95% CI, 1.1 to 3]; p = 0.02) and in severe PE compared to normotensive women [OR = 1.8 (1.1–3), p = 0.02] after adjusting for age, ethnicity, and primiparity. Conclusions: The GG genotype of ERα XbaI polymorphism could be a genetic risk factor for PE predisposition. 相似文献
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Afsaneh Tehranian Roghayeh Hassani Zangbar Faezeh Aghajani Mahdi Sepidarkish Saeedeh Rafiei Tayebe Esfidani 《Gynecological surgery》2017,14(1):17
Background
The aim of this study was to investigate the effect of salpingectomy on ovarian function by measuring AMH.Methods
This study was a balanced, single-center, double-blind, randomized, controlled trial in Ruin Tan Arash Hospital, Tehran, between May 2013 and November 2014. A total of 30 patients undergoing elective abdominal hysterectomy were randomized into two groups, 15 with salpingectomy and 15 without salpingectomy. The primary objective of this study was to compare mean difference of anti-Mullerian hormone (AMH) between two groups. The secondary outcomes measured were follicle-stimulating hormone (FSH), operative time, and blood loss.Results
Serum AMH levels decreased at 3 months after hysterectomy in all patients (pre AMH 1.32 ± (0.91); post AMH 1.05 ± (0.88), P < 0.001), the salpingectomy group (pre AMH 1.44 ± (0.94); post AMH 1.13 ± (0.86), P < 0.001), and no salpingectomy group (pre AMH 1.2 ± (0.9); post AMH 0.97 ± (0.92), P < 0.001). The rate of decline of AMH levels after surgery did not differ between the two groups (25% (17–33%) vs. 26% (15–36%), P = 0.23) among the women with salpingectomy versus without salpingectomy, respectively. There was no difference in the mean operative time (mean difference 0.33, 95% CI ??22.21 to 22.86, P < 0.92), mean blood loss (mean difference ??0.66, 95% CI ??15.8 to 14.46, P < 0.97), and post FSH (mean difference 0.34, 95% CI ??1.2 to 1.88, P < 0.65) between both groups.Conclusions
Salpingectomy with abdominal hysterectomy is a safe treatment that does not have a deleterious effect on ovarian reserve.Trial registration
Iranian Registry of Clinical Trials, IRCT2014123118866N4 (www.IRCT.ir)30.
Saeedeh Shenavandeh Taraneh Tarakemeh Eskandar Kamali Sarvestani Mohammad Ali Nazarinia 《The Egyptian Rheumatologist》2017,39(1):19-24