全文获取类型
收费全文 | 35889篇 |
免费 | 1667篇 |
国内免费 | 148篇 |
专业分类
耳鼻咽喉 | 486篇 |
儿科学 | 652篇 |
妇产科学 | 404篇 |
基础医学 | 4442篇 |
口腔科学 | 1132篇 |
临床医学 | 2444篇 |
内科学 | 8112篇 |
皮肤病学 | 829篇 |
神经病学 | 3506篇 |
特种医学 | 1805篇 |
外国民族医学 | 1篇 |
外科学 | 5476篇 |
综合类 | 128篇 |
一般理论 | 6篇 |
预防医学 | 1111篇 |
眼科学 | 751篇 |
药学 | 2321篇 |
中国医学 | 73篇 |
肿瘤学 | 4025篇 |
出版年
2023年 | 181篇 |
2022年 | 323篇 |
2021年 | 576篇 |
2020年 | 339篇 |
2019年 | 433篇 |
2018年 | 557篇 |
2017年 | 475篇 |
2016年 | 599篇 |
2015年 | 572篇 |
2014年 | 754篇 |
2013年 | 932篇 |
2012年 | 1537篇 |
2011年 | 1565篇 |
2010年 | 967篇 |
2009年 | 825篇 |
2008年 | 1448篇 |
2007年 | 1692篇 |
2006年 | 1557篇 |
2005年 | 1493篇 |
2004年 | 1528篇 |
2003年 | 1448篇 |
2002年 | 1471篇 |
2001年 | 1320篇 |
2000年 | 1434篇 |
1999年 | 1285篇 |
1998年 | 483篇 |
1997年 | 398篇 |
1996年 | 385篇 |
1995年 | 328篇 |
1994年 | 322篇 |
1993年 | 302篇 |
1992年 | 1011篇 |
1991年 | 868篇 |
1990年 | 827篇 |
1989年 | 825篇 |
1988年 | 772篇 |
1987年 | 765篇 |
1986年 | 676篇 |
1985年 | 631篇 |
1984年 | 431篇 |
1983年 | 347篇 |
1979年 | 303篇 |
1978年 | 212篇 |
1977年 | 184篇 |
1974年 | 200篇 |
1973年 | 168篇 |
1972年 | 169篇 |
1971年 | 185篇 |
1970年 | 157篇 |
1969年 | 181篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
991.
992.
993.
994.
Akihiro Nakamura Yuto Monma Shoko Kajitani Kazuki Noda Sota Nakajima Hideaki Endo Tohru Takahashi Eiji Nozaki 《Heart and vessels》2016,31(9):1446-1455
Both postprandial hyperlipidemia and hyperinsulinemia have been thought to play an important role in the development of atherosclerosis, and to be a potent risk factor for cardiovascular event. To examine effects of glycemic state on postprandial hyperlipidemia and hyperinsulinemia in patients with coronary artery disease (CAD), a total of 112 consecutive male patients with angiographically confirmed CAD were loaded with a high-fat and high-glucose test meal. CAD patients were divided into three groups as “non-diabetic”, “prediabetic”, and “diabetic” CAD groups. The serum triglyceride (TG) and remnant-like particle cholesterol (RLP-C) levels at the 6th hour in diabetic CAD group showed significantly higher than non-diabetic CAD group, and the incremental area under the curves (iAUCs) of these levels in diabetic CAD group were significantly greater than non-diabetic CAD group (TG, P = 0.0194; RLP-C, P = 0.0219). There were no significant differences in the iAUCs of TG or RLP-C between prediabetic and non-diabetic CAD group. The AUCs of plasma insulin levels or insulin resistance index (IRI): (AUCs of insulin) × (AUCs of glucose) as the insulin resistance marker were greater in diabetic CAD group than non-diabetic CAD group (insulin, P = 0.0373; IRI, P = 0.0228). The AUCs of serum TG or RLP-C levels showed a correlation with the AUCs of plasma insulin (AUC-TG, r = 0.5437, P < 0.0001; AUC-RLP-C, r = 0.6847, P < 0.0001), and they correlated well with the insulin resistance index (AUC-TG, r = 0.7724, P < 0.0001; AUC-RLP-C, r = 0.7645, P < 0.0001). We found that the insulin resistance showed a close relationship with postprandial hyperlipidemia in CAD patients. Diabetic, but not prediabetic state, may be a risk for postprandial impaired lipid metabolism in CAD patients. 相似文献
995.
996.
997.
Hitoshi Dejima Shigeki Morita Yusuke Takahashi Noriyuki Matsutani Hisae Iinuma Fukuo Kondo Masafumi Kawamura 《International journal of clinical and experimental pathology》2015,8(3):3354-3357
In infants, Langerhans cell histiocytosis (LCH) is associated with poor clinical outcomes as Langerhans cells invade and damage multiple organs, a presentation that is different from that in adults. Here, we present a case of a 15-year-old female who visited ourclinic complaining of right chest pain and dyspnea. She was diagnosed with right pneumothorax by chest X-ray. Chest computed tomography showed multiple cystic changes in the bilateral lung. Additionally, bullous lesions occupying the upper lobe and multiple white tiny nodules on the surface of the lung were observed by thoracoscopy. These nodules comprised proliferating atypical CD1a/S-100-positive cells invading the pulmonary parenchyma, leading to the diagnosis of LCH. Because of the extensive invasion into the pulmonary parenchyma, chemotherapy was administered. This case of LCH was unique in that the age of onset was atypical and the tumor cells occupied a single organ, despite their malignant behavior. 相似文献
998.
Aya Taniguchi Tetsuhiro Ishikawa Masayuki Miyagi Hiroto Kamoda Yoshihiro Sakuma Yasuhiro Oikawa Go Kubota Kazuhide Inage Takeshi Sainoh Junichi Nakamura Yasuchika Aoki Tomoaki Toyone Gen Inoue Miyako Suzuki Kazuyo Yamauchi Takane Suzuki Kazuhisa Takahashi Seiji Ohtori Sumihisa Orita 《International journal of clinical and experimental pathology》2015,8(10):12967-12971
Background: The detailed mechanisms of knee osteoarthritis (OA) pain have not been clarified, but involvement of inflammatory cytokines such as tumor necrosis factor-alpha (TNF) has been suggested. The present study aimed to investigate the more detailed neurological involvement of TNF in joint pain using a TNF-knockout mouse OA model. Methods: The right knees of twelve-week-old C57BL/6J wild and TNF-deficient knockout (TNF-ko) mice (n=15, each group) were given a single intra-articular injection of 10 µg monoiodoacetate in 10 mL sterile saline. The left knees were only punctured as the control. Evaluations were performed immediately after the injection (baseline) and at 7, 14, and 28 days after the injection with a subsequent intra-articular injection of neurotracer into both knees. The animals were evaluated for immunofluorescence of the lumbar dorsal root ganglia (DRG) innervating the knee joints. The injected knees were observed macroscopically and mouse pain-related behaviors were scored. Results: Macroscopic observation showed similar knee OA development in both wild and TNF-ko mice. Calcitonin gene-related peptide (CGRP, a neuropeptide identified as a inflammatory pain-related biomarker) was significantly increased in DRG neurons innervating OA-induced knee joints with significantly less CGRP expression in TNF-ko animals. Pain-related behavior scoring showed a significant increase in pain in OA-induced joints, but there was no significant difference in pain observed between the wild and TNF-ko mice. Conclusions: The result of the present study indicates the possible association of TNF-alpha in OA pain but not OA development. 相似文献
999.
Shigeo Suzuki Kenji Hikosaka Emmanuel O. Balogun Keisuke Komatsuya Mamoru Niikura Fumie Kobayashi Kiwamu Takahashi Tohru Tanaka Motowo Nakajima Kiyoshi Kita 《Antimicrobial agents and chemotherapy》2015,59(11):6960-6967
5-Aminolevulinic acid (ALA) is a naturally occurring amino acid present in diverse organisms and a precursor of heme biosynthesis. ALA is commercially available as a component of cosmetics, dietary supplements, and pharmaceuticals for cancer diagnosis and therapy. Recent reports demonstrated that the combination of ALA and ferrous ion (Fe2+) inhibits the in vitro growth of the human malaria parasite Plasmodium falciparum. To further explore the potential application of ALA and ferrous ion as a combined antimalarial drug for treatment of human malaria, we conducted an in vivo efficacy evaluation. Female C57BL/6J mice were infected with the lethal strain of rodent malaria parasite Plasmodium yoelii 17XL and orally administered ALA plus sodium ferrous citrate (ALA/SFC) as a once-daily treatment. Parasitemia was monitored in the infected mice, and elimination of the parasites was confirmed using diagnostic PCR. Treatment of P. yoelii 17XL-infected mice with ALA/SFC provided curative efficacy in 60% of the mice treated with ALA/SFC at 600/300 mg/kg of body weight; no mice survived when treated with vehicle alone. Interestingly, the cured mice were protected from homologous rechallenge, even when reinfection was attempted more than 230 days after the initial recovery, indicating long-lasting resistance to reinfection with the same parasite. Moreover, parasite-specific antibodies against reported vaccine candidate antigens were found and persisted in the sera of the cured mice. These findings provide clear evidence that ALA/SFC is effective in an experimental animal model of malaria and may facilitate the development of a new class of antimalarial drug. 相似文献
1000.