全文获取类型
收费全文 | 10859篇 |
免费 | 693篇 |
国内免费 | 37篇 |
专业分类
耳鼻咽喉 | 53篇 |
儿科学 | 352篇 |
妇产科学 | 215篇 |
基础医学 | 2029篇 |
口腔科学 | 257篇 |
临床医学 | 860篇 |
内科学 | 2195篇 |
皮肤病学 | 339篇 |
神经病学 | 1360篇 |
特种医学 | 336篇 |
外科学 | 1020篇 |
综合类 | 68篇 |
一般理论 | 6篇 |
预防医学 | 621篇 |
眼科学 | 245篇 |
药学 | 637篇 |
中国医学 | 21篇 |
肿瘤学 | 975篇 |
出版年
2023年 | 65篇 |
2022年 | 143篇 |
2021年 | 251篇 |
2020年 | 194篇 |
2019年 | 273篇 |
2018年 | 311篇 |
2017年 | 192篇 |
2016年 | 299篇 |
2015年 | 320篇 |
2014年 | 402篇 |
2013年 | 525篇 |
2012年 | 789篇 |
2011年 | 831篇 |
2010年 | 432篇 |
2009年 | 451篇 |
2008年 | 692篇 |
2007年 | 726篇 |
2006年 | 685篇 |
2005年 | 674篇 |
2004年 | 651篇 |
2003年 | 582篇 |
2002年 | 482篇 |
2001年 | 128篇 |
2000年 | 113篇 |
1999年 | 126篇 |
1998年 | 135篇 |
1997年 | 79篇 |
1996年 | 79篇 |
1995年 | 76篇 |
1994年 | 53篇 |
1993年 | 47篇 |
1992年 | 51篇 |
1991年 | 43篇 |
1990年 | 57篇 |
1989年 | 49篇 |
1988年 | 37篇 |
1987年 | 34篇 |
1986年 | 26篇 |
1985年 | 34篇 |
1984年 | 27篇 |
1983年 | 26篇 |
1982年 | 22篇 |
1979年 | 36篇 |
1978年 | 17篇 |
1977年 | 21篇 |
1976年 | 22篇 |
1975年 | 22篇 |
1974年 | 19篇 |
1973年 | 26篇 |
1969年 | 16篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
71.
72.
73.
Le Caignec C Baron S McElreavey K Joubert M Rival JM Mechinaud F David A 《American journal of medical genetics. Part A》2003,(1):37-43
46,XY gonadal dysgenesis is characterized by abnormal testicular determination. We describe a large kindred in which various disorders of sexual development were observed, ranging from completely female phenotype without ambiguities of the external genitalia (five cases) to men with isolated penile or perineal hypospadias (four cases), including two cases with moderate virilization and one case with ambiguity of the external genitalia. Histologic examination of gonadal tissue was performed on seven subjects. These findings were suggestive of complete gonadal dysgenesis in one patient, partial gonadal dysgenesis in three patients, and mixed gonadal dysgenesis in three patients. Four patients developed gonadal tumors (two gonadoblastoma, two dysgerminoma, and one immature teratoma, i.e., one patient had a dysgerminoma with some areas of gonadoblastoma). All affected subjects had no other congenital anomalies or dysmorphic features. Analysis of families with several affected individuals with 46,XY gonadal dysgenesis implied an X-linked mode of inheritance because of the apparent absence of male-to-male transmission. However, a sex-limited autosomal dominant mode of inheritance affecting only XY individuals could not be ruled out. Analysis of the pedigree we report indicated an autosomal dominant mode of inheritance because of male-to-male transmission. This kindred supports the involvement of at least one autosomal gene in non-syndromic 46,XY gonadal dysgenesis. 相似文献
74.
P. Yagupsky D. Landau A. Beck R. Dagan 《European journal of clinical microbiology & infectious diseases》1995,14(1):54-58
Infants and toddlers attending ten day-care facilities in closed communities in southern Israel were tested monthly for pharyngeal carriage ofStreptococcus pyogenes and associated respiratory morbidity. Overall, the prevalence ofStreptococcus pyogenes was 2.7 % in infants and 8.4 % in toddlers, reaching 8.5 % and 17.8 % in the two groups, respectively by midwinter. In 4 of 61 (6.6 %) infants and 15 of 67 (22.4 %) toddlers, the organism was recovered in more than one month (range 2 to 5 months).Streptococcus pyogenes in the pharynx was only associated with rhinitis during the spring and summer but not with other respiratory symptoms. During the study period, a mean of 0.9 strains were isolated in day-care facilities attended by infants, while a mean of 2.1 strains were found in toddlers. Young children attending day-care facilities show early acquisition ofStreptococcus pyogenes in the pharynx. 相似文献
75.
Sabine Nick Piero Pileri Stefania Tongiani Yasushi Uematsu Ludwig Kappos Gennaro De Libero 《European journal of immunology》1995,25(2):355-363
To study the relevance of γδ T cells in multiple sclerosis (MS) we analyzed the T cell receptor (TCR) γδ repertoire and the antigen reactivity of γδ clones isolated from cerebrospinal fluid (CSF). In T cell cultures derived from CSF we found an increased percentage of Vδ1+ cells as compared to peripheral blood of the same donors. Phenotypic analysis of cells from MS CSF with Vγ- and Vγ-specific monoclonal antibodies (mAb) showed that the Vγ1 chain is most frequently associated with γ chains belonging to the VγI family. Sequence analysis of TCR genes revealed heterogeneity of junctional regions in both δ and γ genes indicating polyclonal expansion. γδ clones were established and some recognized glioblastoma, astrocytoma or monocytic cell lines. Stimulation with these targets induced serine esterase release and lymphokine expression characteristic of the TH0-like phenotype. Remarkably, these tumor-reactive γδ cells were not detected in the peripheral blood using PCR oligotyping, but were found in other CSF lines independently established from the same MS patient. Altogether, these results demonstrate that in the CSF there is a skewed TCR γδ repertoire and suggest that γδ cells reacting against brain-derived antigens might have been locally expanded. 相似文献
76.
77.
Specificity of sugar transport by the intestine of the hamster 总被引:4,自引:0,他引:4
78.
Expression of adhesion molecules in allergic lung diseases 总被引:4,自引:0,他引:4
Popper HH Pailer S Wurzinger G Feldner H Hesse C Eber E 《Virchows Archiv : an international journal of pathology》2002,440(2):172-180
Endothelial adherence and migration of leukocytes into tissue is mediated by different sets of adhesion molecules. The expression of these sets might not only preselect the types of leukocytes that enter the inflammatory sites, but also activate these leukocytes, induce adherence to epithelial cells, and cause the release of cytokines. Atopic asthma, extrinsic allergic alveolitis, and sarcoidosis as examples of immunologic lung diseases were investigated for the expression of adhesion molecules. Bronchial biopsies in chronic obstructive lung disease (COPD) and resected lung tissue of juvenile emphysema were chosen for controls. Immunohistochemistry was done on sections from bronchial and transbronchial biopsies and on smears from bronchoalveolar lavage cells. In all three types of immune disorders, lymphocytes expressed the integrins alpha4/beta1 (VLA4) and ICAM3, whereas lymphocytes in COPD bronchitis and in emphysema controls were unreactive. Eosinophils in atopic asthma bronchitis in contrast to COPD bronchitis also expressed both VLA4 and ICAM3. The expression of VCAM1 on endothelial cells was only seen in atopic asthma and was related to disease activity. The expression of other adhesion molecules was nonspecific. Expression of VCAM1 on endothelial cells and its ligand VLA4 on lymphocytes and eosinophils seems to be a specific event in atopic asthma. Expression of VLA4 and ICAM3 on lymphocytes, however, might be a specific event in all three immune reactions. 相似文献
79.
R L Nagel J Lynfield J Johnson L Landau R M Bookchin M B Harris 《The New England journal of medicine》1976,295(3):125-130
We found that an abnormal hemoglobin with a very low oxygen affinity was responsible for overt cyanosis in an otherwise healthy adolescent. Hemoglobin Beth Israel, in which serine replaces the asparagine residue normally present at position 102 (G4) of the beta-polypeptide chain, was associated with normal blood counts and no apparent exercise intolerance in the heterozygous carrier. Cyanosis resulted from a drastically right-shifted oxygen dissociation curve, whose position and shape could account for the absence of "physiologic" anemia. The whole-blood oxygen tension at 50 per cent oxygen saturation was 88 mm Hg (normally 26 +/- 1 mm Hg), and the arterial blood was only 63 per cent saturated with oxygen despite a normal oxygen tension of 97 mm Hg. The hemolysate showed a low oxygen affinity but normal Bohr effect. Unexplained cyanosis, particularly in association with normal arterial oxygen tension should prompt a search for an abnormal hemoglobin, which may obviate the need for invasive diagnostic procedures. 相似文献
80.