全文获取类型
收费全文 | 2051088篇 |
免费 | 160350篇 |
国内免费 | 29381篇 |
专业分类
耳鼻咽喉 | 24473篇 |
儿科学 | 60303篇 |
妇产科学 | 50140篇 |
基础医学 | 279723篇 |
口腔科学 | 54561篇 |
临床医学 | 202909篇 |
内科学 | 380952篇 |
皮肤病学 | 42509篇 |
神经病学 | 148147篇 |
特种医学 | 77152篇 |
外国民族医学 | 466篇 |
外科学 | 288309篇 |
综合类 | 108059篇 |
现状与发展 | 90篇 |
一般理论 | 560篇 |
预防医学 | 150928篇 |
眼科学 | 50423篇 |
药学 | 163004篇 |
439篇 | |
中国医学 | 28691篇 |
肿瘤学 | 128981篇 |
出版年
2022年 | 19413篇 |
2021年 | 30693篇 |
2020年 | 22223篇 |
2019年 | 24907篇 |
2018年 | 31725篇 |
2017年 | 26614篇 |
2016年 | 27065篇 |
2015年 | 35363篇 |
2014年 | 46620篇 |
2013年 | 56464篇 |
2012年 | 80171篇 |
2011年 | 86337篇 |
2010年 | 53730篇 |
2009年 | 47703篇 |
2008年 | 72101篇 |
2007年 | 75149篇 |
2006年 | 74629篇 |
2005年 | 71128篇 |
2004年 | 62901篇 |
2003年 | 59855篇 |
2002年 | 55937篇 |
2001年 | 99323篇 |
2000年 | 100916篇 |
1999年 | 84523篇 |
1998年 | 24753篇 |
1997年 | 22156篇 |
1996年 | 21220篇 |
1995年 | 20336篇 |
1994年 | 18319篇 |
1993年 | 16010篇 |
1992年 | 59441篇 |
1991年 | 57074篇 |
1990年 | 54512篇 |
1989年 | 52056篇 |
1988年 | 47212篇 |
1987年 | 45928篇 |
1986年 | 42982篇 |
1985年 | 40536篇 |
1984年 | 29628篇 |
1983年 | 25106篇 |
1982年 | 13995篇 |
1979年 | 25631篇 |
1978年 | 17631篇 |
1977年 | 14948篇 |
1976年 | 13902篇 |
1975年 | 14587篇 |
1974年 | 17661篇 |
1973年 | 16974篇 |
1972年 | 15702篇 |
1971年 | 14472篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
71.
72.
Improvement in Tricuspid Annular Plane Systolic Excursion with Pulmonary Hypertension Therapy in Pediatric Patients
下载免费PDF全文
![点击此处可从《Echocardiography (Mount Kisco, N.Y.)》网站下载免费的PDF全文](/ch/ext_images/free.gif)
73.
74.
75.
76.
77.
目的以基因表达数据集资料为研究对象,分析BCAN基因在肾透明细胞癌中的表达情况以及对患者预后的影响。方法在Oncomine数据库中挖掘BCAN在肾透明细胞癌(ccRCC)中的表达情况。从TCGA数据库中获取ccRCC患者临床资料和目的基因的表达信息并进行统计分析。利用GEO数据库中GSE73731数据集的ccRCC样本进行基因富集分析。利用String数据库分析与BCAN相关的蛋白。结果BCAN低表达组的ccRCC患者在病理分期及T分期方面低于高表达组(P<0.001;P=0.001);N分期及M分期差异无统计学意义(P>0.05)。BCAN低表达组患者的总生存期优于高表达组(P=0.033)。BCAN基因高表达组的样本主要富集在KRAS信号通路。结论BCAN可以通过多种途径来促进肿瘤细胞的侵袭能力,有望成为ccRCC不良预后的重要生物标志物之一。 相似文献
78.
患者男,64岁,因头颅增大、面部变长,颧骨隆起、下颌增大、双手掌肥厚、双手指粗短30余年,乳房肿物1年余就诊。患者30余年前无明显诱因出现渐进性手足增大,双手掌肥厚,嘴唇变厚,下颌增大,眉弓及颧骨突出,皮肤增厚,无乳腺增大、泌乳,未诊治…… 相似文献
79.
皮肤损伤后的异常愈合会导致病理性瘢痕的产生。病理性瘢痕的出现不仅影响美观,严重时还会造成心理和生理功能障碍。病理性瘢痕的机制研究对于瘢痕治疗有极为重要的意义。其中,动物瘢痕模型是目前研究病理性瘢痕的重要模型手段之一。理想的动物瘢痕模型应该在组织学、细胞学等层面尽可能接近于人类的病理性瘢痕。该文分别从传统技术动物瘢痕中的啮齿类动物模型、兔耳模型和猪模型,以及新技术动物瘢痕模型这两个方面,结合近年来在瘢痕领域应用较多的研究,进行了相应系统的阐述。 相似文献
80.
C.Z. Simonsen S. Schnenberger P.L. Hendn A.J. Yoo L. Uhlmann A. Rentzos J. Bsel J. Valentin M. Rasmussen 《AJNR. American journal of neuroradiology》2020,41(12):2298
BACKGROUND AND PURPOSE:Endovascular therapy for acute ischemic stroke is often performed with the patient under conscious sedation. Emergent conversion from conscious sedation to general anesthesia is sometimes necessary. The aim of this study was to assess the functional outcome in converted patients compared with patients who remained in conscious sedation and to identify predictors associated with the risk of conversion.MATERIALS AND METHODS:Data from 368 patients, included in 3 trials randomizing between conscious sedation and general anesthesia before endovascular therapy (SIESTA, ANSTROKE, and GOLIATH) constituted the study cohort. Twenty-one (11%) of 185 patients randomized to conscious sedation were emergently converted to general anesthesia.RESULTS:Absence of hyperlipidemia seemed to be the strongest predictor of conversion to general anesthesia, albeit a weak predictor (area under curve = 0.62). Sex, hypertension, diabetes, smoking status, atrial fibrillation, blood pressure, size of the infarct, and level and side of the occlusion were not significantly associated with conversion to general anesthesia. Neither age (mean age, 71.3 ± 13.8 years for conscious sedation versus 71.6 ± 12.3 years for converters, P = .58) nor severity of stroke (mean NIHSS score, 17 ± 4 versus 18 ± 4, respectively, P = .27) were significantly different between converters and those who tolerated conscious sedation. The converters had significantly worse outcome with a common odds ratio of 2.67 (P = .015) for a shift toward a higher mRS score compared with the patients remaining in the conscious sedation group.CONCLUSIONS:Patients undergoing conversion had significantly worse outcome compared with patients remaining in conscious sedation. No factor was identified that predicted conversion from conscious sedation to general anesthesia.Five studies published in 2015 proved the efficacy of endovascular therapy (EVT) for acute ischemic stroke caused by a large-vessel occlusion.1 However, numerous questions remain regarding how to best deliver this treatment, including evaluation of the optimal thrombectomy technique,2 the most effective method of patient triage,3 or whether EVT should be performed with the patient under either general anesthesia (GA) or conscious sedation (CS).Observational studies have suggested that EVT with the patient under CS is associated with better neurologic outcome and lower mortality compared with GA.4 However, 3 randomized trials reported similar outcomes between CS and GA.5-7 Proposed benefits of CS include stable hemodynamics, clinical monitoring, and a potentially shorter procedure. The disadvantages are an unprotected airway and patient movement, which sometimes may require emergent conversion to GA. Patients who need conversion might be sicker (larger strokes, more medical complications), but the conversion procedure itself may also have a potentially deleterious influence on outcome due to the emergent anesthetic induction, associated hypotension, and added time delay before reperfusion.Although most patients can be treated under the less complex CS, it is of interest to identify factors that can predict the risk of conversion and hence the requirement for GA. We undertook a detailed analysis of the patients who were converted from CS to GA in our individual patient data base from the 3 randomized trials to examine the outcome of the converted patients compared with patients who remained in CS. We also aimed to identify possible predictors associated with a need for GA with EVT. 相似文献