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161.
Adel?OlaszEmail author Eidi?Christensen Runa?Braun Olav?A.?Foss Lars-K?re?Dotterud 《European journal of dermatology : EJD》2018,28(6):818-822
Background
The use of skin puncture techniques may facilitate the delivery of topically applied drugs for photodynamic therapy (PDT).Objectives
The main aim of this prospective study was to evaluate the efficacy and cosmetic outcome of curettage, multiple needle puncture, and methyl-aminolaevulinate (MAL)-PDT in basal cell carcinoma (BCC).Materials and methods
All tumours received curettage and 15-20 needle punctures/cm2 before two sessions of MAL-PDT. The primary endpoint was clinically observed recurrence at follow-up. Overall, 284 patients with 299 histologically verified BCC (70 superficial, 190 nodular, 35 aggressive, and four not subtyped) were included. Following PDT, the mean follow-up period was 6.7 months.Results
After follow-up, 274 (92%) of 299 treatment sites showed no clinical signs of recurrence, with >90% complete response for each BCC subtype. The cosmetic outcome was rated as excellent/good in 81% of cases.Conclusion
Good short-term treatment results were shown following curettage, multiple needle puncture, and MAL-PDT for BCC of different subtypes.162.
Kenji Iemura Hayato Anzawa Ryo Funayama Runa Iwakami Keiko Nakayama Kengo Kinoshita Kozo Tanaka 《Cancer science》2022,113(8):2727
Most cancer cells show chromosomal instability (CIN), a condition in which chromosome missegregation occurs at high rates. Growing evidence suggests that CIN is not just a consequence of, but a driving force for, oncogenic transformation, although the relationship between CIN and tumorigenesis has not been fully elucidated. Here we found that conventional two‐dimensional (2D) culture of HeLa cells, a cervical cancer‐derived cell line, was a heterogenous population containing cells with different CIN levels. Although cells with high‐CIN levels (high‐CIN cells) grew more slowly compared with cells with low‐CIN levels (low‐CIN cells) in 2D monolayer culture, they formed tumors in nude mice and larger spheres in three‐dimensional (3D) culture, which was more representative of the in vivo environment. The duration of mitosis was longer in high‐CIN cells, reflecting their higher mitotic defects. Single‐cell genome sequencing revealed that high‐CIN cells exhibited a higher karyotype heterogeneity compared with low‐CIN cells. Intriguingly, the karyotype heterogeneity was reduced in the spheres formed by high‐CIN cells, suggesting that cells with growth advantages were selected, although genomic copy number changes specific for spheres were not identified. When we examined gene expression profiles, genes related to the K‐ras signaling were upregulated, while those related to the unfolded protein response were downregulated in high‐CIN cells in 3D culture compared with 2D culture, suggesting the relevance of these genes for their survival. Our data suggested that, although CIN is disadvantageous in monolayer culture, it promotes the selection of cells with growth advantages under in vivo environments, which may lead to tumorigenesis. 相似文献
163.
Irena Papadopoulos Steve Wright Christina Koulouglioti Sheila Ali Runa Lazzarino Ángel Martín-García Cristina Oter-Quintana Christiana Kouta Elena Rousou Katalin Papp Radka Krepinska Valerie Tothova Maria Malliarou Paraskevi Apostolara Małgorzata Lesińska-Sawicka Małgorzata Nagorska Miroslava Liskova Line Nortvedt Lise-Merete Alpers Sylvia Biglete-Pangilinan Ma. Florinda Oconer-Rubiano Wireeporn Chaisetsampun Nutchanath Wichit Akhtar-Ebrahimi Ghassemi Ezzat Jafarjalal Akile Zorba Andrea Kuckert-Wöstheinrich Rabin Malla Tomiko Toda Özlem Akman Candan Öztürk Teresa Puvimanasinghe Tahereh Ziaian Orit Eldar-Regev Sara Nissim 《Japan Journal of Nursing Science》2023,20(2):e12523