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Marco Antonio Palma Rocio Ortiz Carlos Alvarez-Dardet Maria T. Ruiz 《Social science & medicine (1982)》2009
The possible effect of Government Consumption (a component of Gross Domestic Product (GDP)) on attainment of the hunger Millennium Development Goal (MDG1) was analyzed by evaluating the effect of macroeconomic, social, demographic and policy variables on average undernourished population. Eighty-four developing countries with data available on undernourished population were included in an ecological study. Regression models were applied to explore possible determinants of Undernourished between 1990 and 2004 and consequent achievement of the projected 2004 MDG1. In 2004, 1.4% of the overall undernourished population in the studied countries [70.16 million people] was in excess of the projected level required to meet MDG1. The multiple linear regression showed significant associations between Undernourished and poverty levels, the Gini Index, rural population and Government Consumption. The multiple logistic regression showed significant associations between achievement of projected 2004 MDG1 levels and Government Consumption and the Gini Index. The significant associations between Undernourished and Government Consumption suggest that the effects of GDP components on social conditions call for more thorough research and that policymakers such as governments and international financial institutions need to ensure that changes in distributive and redistributive policies do not negatively affect the possibility of achieving MDG1. 相似文献
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Characterization and isolation of SOB2, a human sperm protein with a potential role in oocyte membrane binding 总被引:2,自引:1,他引:1
Lefevre A; Martin Ruiz C; Chokomian S; Duquenne C; Finaz C 《Molecular human reproduction》1997,3(6):507-516
G12 monoclonal antibody (mAb), one of a library of constructed mAb directed
against human sperm proteins, was found by immunoperoxidase staining to
label the post-acrosomal and neck regions of fixed human cauda epididymal
and ejaculated spermatozoa. Epithelium and fluid of caput epididymis were
strongly labelled while there was no staining on testis and efferent ducts.
Western lot analysis revealed that G12 antibody reacted with proteins of
17.5, 18 and 19 kDa in human spermatozoa. This pattern seems to be specific
for mature human spermatozoa, as it has not been observed either in other
human tissues tested, or in spermatozoa from different animals. SOB2, the
corresponding protein, was isolated from NP40-extracted human spermatozoa
by using preparative electrophoresis, followed by isoelectrofocusing
according to its isoelectric point of 6.4 G12 Fab fragments strongly
inhibited binding of human spermatozoa to zona-free hamster oocytes (up to
86% inhibition at 200 micrograms/ml). Impairment of binding was dependent
on the concentration of purified G12 immunoglobulin (Ig)G1, and significant
even at 10 micrograms/ml. There was no inhibitory effect of G12 antibody on
sperm motility parameters or triggering of the acrosome reaction and it did
not inhibit binding to human zona pellucida. These results indicate that
SOB2 is likely to participate in membrane oocyte binding, and my be
potential candidate for the development of a contraceptive vaccine.
相似文献
16.
AM Manganoni† C Farisoglio† G Tucci† F Facchetti‡ PG Calzavara Pinton† 《Journal of the European Academy of Dermatology and Venereology》2007,21(10):1333-1336
BACKGROUND: Development of more than one primary melanoma in a patient is a relatively uncommon but well-recognized phenomenon. Its frequency has ranged from 1.2% to 8.2% in several series. This subgroup of patients with multiple primary lesions has not been characterized sufficiently. We report the experience of the Melanoma Unit of University Hospital Spedali Civili of Brescia, Italy. METHOD: Study subjects were drawn from 1240 patients with histologically confirmed melanoma, including melanoma in situ. From this group, multiple melanomas developed in 47 patients (3.79%). Every one of our patients has been taught to perform self-examination of the skin to detect suspicious pigmented lesions. RESULTS: Of the 47 patients described in this study, 38 had two primary melanomas, 7 had three melanomas and 2 had 5 and 10 melanomas, respectively. Mean age at first diagnosis was 46.2 years. The majority of subsequent melanomas (74.5%) were removed within 5 years of the initial operation. Synchronous lesions were found in 10 patients. In male patients, the lesion appeared most frequently on the trunk; in female patients, melanoma appeared mostly on the lower extremities. The second primary melanomas developed in the same anatomic region from the first in 53.2% of our patients. The proportion of in situ to invasive melanomas was greater for the second melanomas compared with the first melanomas. Regarding invasive melanomas, the mean thickness of the first melanomas was 1.31 mm compared with 0.66 mm for the second ones. Dividing patients into two groups, of more and less than 50, it is highlighted that in older patients synchronous lesions appear more frequently (36.4% vs. 8.0%); the median time interval between sequential melanomas is longer (84 vs. 63.7 months); and the ratio between the primary and secondary melanoma mean thickness is lower (1.21 : 1.08 vs. 1.43 : 0.63 mm). CONCLUSIONS: The study confirms that second primary melanoma is usually thinner than the first lesion, and it is more common in the same region of the body as the initial melanoma. The highest risk for a second melanoma is during the first 5 years, but a much longer time interval of 28 years is possible. Continued medical follow-up with complete skin examinations seems prudent, but it is very important to promote self-skin evaluation in patients to detect not only metastases but also subsequent primary melanomas in their earliest phases. 相似文献
17.
Claude Clément MD Roberto Ruiz MD Bogdan Costa-Foru MD Hubert Nicaise MD 《Annals of vascular surgery》1990,4(3):305-308
Extrinsic compression of the renal artery due to a fibromuscular band originating from the diaphragm was encountered in a 26-year-old patient who had systemic hypertension associated with stenosis and kinking of one of her renal arteries. After surgical decompression, the renal artery assumed a normal expansion with disappearance of hypertension. Six other cases of extrinsic compression of the renal artery have been found in the literature. Surgical treatment is mandatory in all cases because the mechanism that causes the lesion makes percutaneous transluminal angioplasty illusory. 相似文献
18.
M L Brooks D P Mayer R T Sataloff D L Myers J R Spiegel S Ruiz 《Computerized medical imaging and graphics》1992,16(4):283-285
A patient with a surgically proven intracanalicular arachnoid cyst was studied using computed tomography, magnetic resonance imaging, and air CT cisternography. The lesion had a similar radiographic appearance to acoustic neuroma and therefore, although rare, must be considered in the differential diagnosis of intracanalicular mass lesions. We report a case in which examination was performed, in evaluating the lesion, utilizing high-resolution air CT cisternography and magnetic resonance imaging (MRI). 相似文献
19.
Congenital oesophagobronchial fistula in an adult involving left main bronchus. 总被引:1,自引:0,他引:1 下载免费PDF全文
M Moreno Azcoita J C Ruiz de Adana L Snchez Urdazpal C Crcamo J M Jover Navaln J L Ramos Rodriguez 《Thorax》1994,49(8):835-836
Congenital fistulae between the tracheobronchial tree and oesophagus usually originate from the lower end of the trachea or right main bronchus. The case history is presented of a man in whom a fistula between the oesophagus and left main bronchus was not diagnosed until the age of 48. 相似文献
20.
The literature on this rare tumour has been reviewed and three cases of nasal plasmacytoma are described. Immunohistochemistry demonstrated cytoplasmic IgA and Kappa determinants in all cases. Two patients are disease-free at the present time, the third developed an IgG-k multiple myeloma, previously not described in the literature. 相似文献