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991.
Parente A Angulo JM Romero RM Rivas S Corona C Tardáguila AR 《Actas urologicas espa?olas》2011,35(7):429-433
IntroductionThe closure of urinary diversions performed on newly born infants has a notable failure percentage in patients with bladder disease. We present the use of botulinum toxin as a useful and minimally invasive alternative to treat these patients.Material and methodsWe present two patients with a single kidney and with posterior urethral valves (PUV), in whom it was necessary to perform a ureterostomy due to chronic kidney disease. In both patients, the subsequent attempt to close the diversion failed. Aged 4 and 10 years respectively, they presented bladders commonly known as “dry bladders”, with a low capacity (20 and 110 ml), bad adaptation (1.5 and 3.1 ml/ cm H2O) and high opening detrusor pressure. A 10 UI/Kg botulinum toxin A puncture was applied in the detrusor on one and two occasions respectively, prior to the closure of the diversion.ResultsNeither of the patients suffered clinical or ecographic worsening after the closure of the diversion and their kidney function continued without change with respect to the first diversion after one and four years of follow-up respectively. One year after the surgical procedure, video urodynamics showed a significant improvement in bladder capacity (451 and 250 ml), in adaptation (20.4 and 81.9 ml/cmH2O) and in the opening detrusor pressure.ConclusionsThe closure of high urinary diversions has a high failure percentage in infants with pathological high-pressure bladders. Botulinum toxin may be useful as bladder treatment prior to closure of the diversion, especially in patients with a single kidney. 相似文献
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Orradre Burusco I Romero R Brun M López Blasco JJ 《Archives of orthopaedic and trauma surgery》2011,131(12):1711-1716
Background
Recent data indicate that enhanced wear resistance can be obtained with new cross-linked ultra-high-molecular weight polyethylene (CL-UHMWPE) liners, in comparison with previous-generation liners. The current prospective, cohort study was undertaken to analyse whether the use of a new CL-UHMWPE (Rexpol) results in a lower wear rate than ultra-high-molecular weight polyethylene (UHMWPE) in a group of similar patients undergoing total hip arthroplasty (THA). This study provides the first clinical data with this particular CL-UHMWPE. 相似文献999.
Omar Yaxmehen Bello‐Chavolla Neftali E. Antonio‐Villa Arsenio Vargas‐Vzquez Alexandro J. Martagn Roopa Mehta Olimpia Arellano‐Campos Donaji V. Gmez‐Velasco Paloma Almeda‐Valds Ivette Cruz‐Bautista Marco A. Melgarejo‐Hernandez Liliana Muoz‐Hernandez Luz E. Guilln Jos de Jesús Garduo‐García Ulices Alvirde Yukiko Ono‐Yoshikawa Ricardo Choza‐Romero Leobardo Sauque‐Reyna Ma. Eugenia Garay‐Sevilla Juan M. Malacara‐Hernandez María T. Tusi‐Luna Luis M. Gutierrez‐Robledo Francisco J. Gmez‐Prez Rosalba Rojas Carlos A. Aguilar‐Salinas 《Journal of clinical hypertension (Greenwich, Conn.)》2019,21(8):1063-1070
Hypertension is associated with insulin resistance (IR), metabolic syndrome (MS), and arterial stiffness. Non–insulin‐based IR indexes were developed as tools for metabolic screening. Here, we aimed to evaluate the novel non–insulin‐based Metabolic Score for IR (METS‐IR) index for the prediction of incident hypertension and arterial stiffness evaluated using pulse wave velocity (PWV) analysis, compared with other non–insulin‐based IR indexes. We evaluated two populations, a cross‐sectional evaluation of high‐risk individuals (n = 305) with a wide range of metabolic comorbidities and dyslipidemia in whom PWV measurement was performed and a 3‐year prospective cohort of normotensive individuals (N = 6850). We observed a positive correlation between METS‐IR and PWV in the cross‐sectional cohort, which was higher compared with other non–insulin‐based fasting IR indexes; furthermore, PWV values >75th percentile were associated with the upper tercile of METS‐IR values. In the prospective cohort, we observed an increased risk for incident hypertension for the upper METS‐IR tercile (METS‐IR ≥ 46.42; HR: 1.81, 95% CI: 1.41‐2.34), adjusted for known cardiovascular risk factors, and observed that METS‐IR had greater increases in the predictive capacity for hypertension along with SBP and the Framingham Hypertension Risk Prediction Model compared with other non–insulin‐based IR indexes. Therefore, METS‐IR is a novel non–insulin‐based IR index which correlates with arterial stiffness and is a predictor of incident hypertension, complementary to previously validated risk prediction models. 相似文献
1000.
Marta Hernndez‐Conde Inmaculada Fernndez Christie Perell Adolfo Gallego Martin Bonacci Juan M. Pascasio Manuel Romero‐Gmez Susana Llerena Conrado Fernndez‐Rodríguez Jos L. Castro Urda Luisa García Buey Isabel Carmona Rosa M. Morillas Nuria Domínguez García Francisco Gea Jos A. Carrin Jose Castellote Jose M. Moreno‐Planas Beln Piqueras Alcol Esther Molina Moises Diago Silvia Montoliu Juan de la Vega Fernando Menndez Juan J. Snchez Ruano Javier García‐Samaniego Jose M. Rosales‐Zabal María D. Anton Ester Badia Raquel Souto‐Rodríguez Francisco J. Salmeron Miguel Fernndez‐Bermejo Blanca Figueruela Jose J. Moreno‐Palomares Jose L. Calleja 《Journal of viral hepatitis》2019,26(1):55-64
In randomized controlled trials of patients with chronic HCV infection, elbasvir/grazoprevir (EBR/GZR) demonstrated high cure rates and a good safety profile. This study assessed the effectiveness and safety of EBR/GZR, with and without ribavirin, in a real‐world HCV patient cohort. HEPA‐C is a collaborative, monitored national registry of HCV patients directed by the Spanish Association for the Study of the Liver and the Networked Biomedical Research Centre for Hepatic and Digestive Diseases. Patients entered into HEPA‐C between December 2016 and May 2017, and treated with EBR/GZR with at least end‐of‐treatment response data, were included. Demographic, clinical and virologic data were analysed, and adverse events (AEs) recorded. A total of 804 patients were included in the study. The majority were male (57.9%), with a mean age of 60 (range, 19‐92) years. Genotype (GT) distribution was GT 1, 86.8% (1a, 14.3%; 1b, 72.5%); GT 4, 13.2% and 176 patients (21.9%) were cirrhotic. Overall, among 588 patients with available data, 570 (96.9%) achieved sustained virologic response at 12 weeks post‐treatment (SVR12). SVR12 rates by genotype were GT 1a, 97.7%; GT 1b, 98.6%; and GT 4, 98.1%. No significant differences in SVR12 according to fibrosis stage were observed. Eighty patients experienced an AE, resulting in treatment discontinuation in three. In this large cohort of patients with chronic HCV managed in a real‐world setting in Spain, EBR/GZR achieved high rates of SVR12, comparable to those observed in randomized controlled trials, with a similarly good safety profile. 相似文献