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The catechol‐O‐methyltransferase (COMT) Val158Met genotype modulates working memory‐related dorsolateral prefrontal response and performance in bipolar disorder
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1 材料和方法1. 1 材料 我院 2003 02 /2004 12对子宫肌瘤、子宫腺肌症,采用腹式横切口鞘内全子宫切除术 26例.同时随机选择 22例常规全子宫切除术宫颈楔形切除术作为对照组,两组年龄分别为 43±4(38~52)岁, 41±6(38 ~53)岁,患者年龄,手术适应证及子宫大小两组间无显著性差异,具有可比性.1. 2 方法 ①连续硬膜外麻醉,取膀胱截石位,采用耻 2~3横形切 10~12cm,仅切开皮肤,撕开脂肪及筋膜,钝性加锐性分离肌肉与筋膜粘着处,钝性分离腹直肌,腹膜剪一小横口,切开腹膜.用腹纱牵开肠宫,大块纱布排垫肠管,大弯钳钳夹子宫两角尽量钳拉子宫至腹腔… 相似文献
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1临床资料 1997-06/2004—10共连续施行肝移植52例,发生神经精神并发症12例,其中严重2例,均为男性,年龄为56岁和38岁,原发病均为乙型肝硬化,均经背驮式肝移植.术前6h服用3mgFKS06,术后拔管后给予FK506口服,0.07mg/kg,同时常规应用强的松及骁悉口服,应用ELISA法动态监测患者全血FK506浓度,使其保持在10~12μg/L.分别在术后2d和4d出现神经精神并发症,并逐渐加重,开始以谵妄样精神障碍为主要症状,发展为癫痫发作和深昏迷,随时间的延长,出现排痰不畅、高热、大量胸水等症状. 相似文献
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Background
Empirical and scientific studies prove the causality between a company’s sustainable value creation and its focus on the respective target customer. The most success is granted to those companies that establish a robust relationship with their customers on a broad analytical basis.Results
This study aimed to establish a multidimensional, customer-related value management system that allows segmentation of the customer base of a compulsory health insurance fund according to strategic and action-oriented parameters. For the first time, a customized system was developed specifically for this branch.Conclusions
Customer understanding is the basis for the development of strategic initiatives for communication, customer retention, and sales; for product portfolio management; and for risk management systems in the sense of broad, value-based management of medical care. 相似文献569.
Chemokines and pain 总被引:1,自引:0,他引:1
Rittner HL Brack A 《Current opinion in investigational drugs (London, England : 2000)》2006,7(7):643-646
Chemokines are chemotactic mediators controlling cell trafficking under physiological and pathological conditions. Recently, it has been discovered that chemokines are not only important in various inflammatory conditions, but that they also play a role in pain and analgesia. Chemokine function in the periphery has been evaluated under non-inflammatory, inflammatory and neuropathic conditions. While many studies have examined the hyperalgesic action of chemokines, increasing evidence points to the antinociceptive properties of chemokines. This review focuses on the role of chemokines in the peripheral tissue. 相似文献
570.
A significant increase in thromboembolic events (i.e. myocardial infarction and stroke) was demonstrated in multicenter studies after several months of treatment with cyclooxygenase 2 (cox-2) inhibitors. In February 2005, the European medical agencies (EMEA) substantially increased the number of contraindications for all cox-2 inhibitors. They are now contraindicated for patients with coronary artery disease. Furthermore, 2 out of 6 cox-2 inhibitors have been withdrawn from the market. In this review, the current state of knowledge on the use of cox-2 inhibitors in perioperative pain therapy is summarized: i) they are equally as potent as other non-opioid analgesics, ii) they decrease opioid consumption, iii) a reduction in postoperative nausea and vomiting (PONV) has not been adequately demonstrated. Regarding side-effects, it can be concluded that i) the incidence of thromboembolic events is increased in patients undergoing coronary artery bypass surgery, ii) perioperative blood loss is not affected, iii) ulcer formation is not promoted, iv) the risk for acute renal failure is probably increased to the same extent as for NSAIDs and v) severe bronchospasm can be triggered in patients with asthma and chronic obstructive pulmonary disease (COPD). 相似文献