全文获取类型
收费全文 | 256151篇 |
免费 | 42178篇 |
国内免费 | 1515篇 |
专业分类
耳鼻咽喉 | 4541篇 |
儿科学 | 6840篇 |
妇产科学 | 5484篇 |
基础医学 | 24512篇 |
口腔科学 | 8269篇 |
临床医学 | 43134篇 |
内科学 | 56680篇 |
皮肤病学 | 5663篇 |
神经病学 | 26719篇 |
特种医学 | 8908篇 |
外国民族医学 | 5篇 |
外科学 | 40465篇 |
综合类 | 2878篇 |
现状与发展 | 41篇 |
一般理论 | 194篇 |
预防医学 | 28173篇 |
眼科学 | 5556篇 |
药学 | 12957篇 |
2篇 | |
中国医学 | 237篇 |
肿瘤学 | 18586篇 |
出版年
2024年 | 790篇 |
2023年 | 5507篇 |
2022年 | 2094篇 |
2021年 | 5133篇 |
2020年 | 6680篇 |
2019年 | 4461篇 |
2018年 | 9581篇 |
2017年 | 9295篇 |
2016年 | 10126篇 |
2015年 | 10730篇 |
2014年 | 14328篇 |
2013年 | 18277篇 |
2012年 | 12966篇 |
2011年 | 13318篇 |
2010年 | 12183篇 |
2009年 | 14027篇 |
2008年 | 12731篇 |
2007年 | 12345篇 |
2006年 | 13264篇 |
2005年 | 12156篇 |
2004年 | 11021篇 |
2003年 | 10531篇 |
2002年 | 10081篇 |
2001年 | 4429篇 |
2000年 | 3573篇 |
1999年 | 4179篇 |
1998年 | 4259篇 |
1997年 | 3695篇 |
1996年 | 3428篇 |
1995年 | 3197篇 |
1994年 | 2382篇 |
1993年 | 2213篇 |
1992年 | 2549篇 |
1991年 | 2324篇 |
1990年 | 2169篇 |
1989年 | 2047篇 |
1988年 | 1908篇 |
1987年 | 1787篇 |
1986年 | 1727篇 |
1985年 | 1799篇 |
1984年 | 1752篇 |
1983年 | 1699篇 |
1982年 | 1790篇 |
1981年 | 1573篇 |
1980年 | 1414篇 |
1979年 | 1098篇 |
1978年 | 1126篇 |
1977年 | 1011篇 |
1976年 | 892篇 |
1974年 | 807篇 |
排序方式: 共有10000条查询结果,搜索用时 29 毫秒
11.
Kara S. Tanaka MD Veronica R. Andaya BA Steven W. Thorpe MD Kenneth R. Gundle MD James B. Hayden MD Yee-Cheen Duong MD Raffi S. Avedian MD David G. Mohler MD Lee J. Morse MD Melissa N. Zimel MD Richard J. O'Donnell MD Andrew Fang MD Robert Lor Randall MD Tina H. Tran BS Christin New BA Rosanna L. Wustrack MD other members of Study Group FORCE 《Journal of surgical oncology》2023,127(1):148-158
12.
13.
14.
Two Janus-associated kinase inhibitors (JAKi) (initially ruxolitinib and, more recently, fedratinib) have been approved as treatment options for patients who have intermediate-risk and high-risk myelofibrosis (MF), with pivotal trials demonstrating improvements in spleen volume, disease symptoms, and quality of life. At the same time, however, clinical trial experiences with JAKi agents in MF have demonstrated a high frequency of discontinuations because of adverse events or progressive disease. In addition, overall survival benefits and clinical and molecular predictors of response have not been established in this population, for which the disease burden is high and treatment options are limited. Consistently poor outcomes have been documented after JAKi discontinuation, with survival durations after ruxolitinib ranging from 11 to 16 months across several studies. To address such a high unmet therapeutic need, various non-JAKi agents are being actively explored (in combination with ruxolitinib in first-line or salvage settings and/or as monotherapy in JAKi-pretreated patients) in phase 3 clinical trials, including pelabresib (a bromodomain and extraterminal domain inhibitor), navitoclax (a B-cell lymphoma 2/B-cell lymphoma 2-xL inhibitor), parsaclisib (a phosphoinositide 3-kinase inhibitor), navtemadlin (formerly KRT-232; a murine double-minute chromosome 2 inhibitor), and imetelstat (a telomerase inhibitor). The breadth of data expected from these trials will provide insight into the ability of non-JAKi treatments to modify the natural history of MF. 相似文献
15.
Raymond J. Chan RN PhD Vivienne E. Milch MBBS MHPol Fiona Crawford-Williams PhD Oluwaseyifunmi Andi Agbejule BRadTherapy Ria Joseph MNutrDiet Jolyn Johal BND Narayanee Dick BSc Matthew P. Wallen PhD Julie Ratcliffe PhD Anupriya Agarwal MBBS Larissa Nekhlyudov MD Matthew Tieu PhD Manaf Al-Momani BPharm Scott Turnbull PhD Rahul Sathiaraj MPH Dorothy Keefe MBBS MD Nicolas H. Hart PhD 《CA: a cancer journal for clinicians》2023,73(6):565-589
Patient navigation is a strategy for overcoming barriers to reduce disparities and to improve access and outcomes. The aim of this umbrella review was to identify, critically appraise, synthesize, and present the best available evidence to inform policy and planning regarding patient navigation across the cancer continuum. Systematic reviews examining navigation in cancer care were identified in the Cochrane Central Register of Controlled Trials (CENTRAL), PubMed, Embase, Cumulative Index of Nursing and Allied Health (CINAHL), Epistemonikos, and Prospective Register of Systematic Reviews (PROSPERO) databases and in the gray literature from January 1, 2012, to April 19, 2022. Data were screened, extracted, and appraised independently by two authors. The JBI Critical Appraisal Checklist for Systematic Review and Research Syntheses was used for quality appraisal. Emerging literature up to May 25, 2022, was also explored to capture primary research published beyond the coverage of included systematic reviews. Of the 2062 unique records identified, 61 systematic reviews were included. Fifty-four reviews were quantitative or mixed-methods reviews, reporting on the effectiveness of cancer patient navigation, including 12 reviews reporting costs or cost-effectiveness outcomes. Seven qualitative reviews explored navigation needs, barriers, and experiences. In addition, 53 primary studies published since 2021 were included. Patient navigation is effective in improving participation in cancer screening and reducing the time from screening to diagnosis and from diagnosis to treatment initiation. Emerging evidence suggests that patient navigation improves quality of life and patient satisfaction with care in the survivorship phase and reduces hospital readmission in the active treatment and survivorship care phases. Palliative care data were extremely limited. Economic evaluations from the United States suggest the potential cost-effectiveness of navigation in screening programs. 相似文献
16.
17.
18.
19.
Kuo-yi Jade Chang MHealthEc MHM BSc Lisa Lorraine Dillon MSpecEd BPsych Lil Deverell COMS PhD MEd GradDipO&M BEd Mei Ying Boon PhD BOptom FAAO Lisa Keay PhD MPH BOptom 《Clinical & experimental optometry》2020,103(4):434-448
Despite orientation and mobility (O&M) being a significant factor determining quality of life of people with low vision or blindness, there are no gold standard measures or agreement on how to measure O&M performance. In the first part of this systematic review, an inventory of O&M outcome measures used by recent studies to assess the performance of orientation and/or mobility of adults with vision impairment (low vision and blindness) is presented. A wide variety of O&M outcome measures have been implemented in different fields of study, such as epidemiologic research and interventional studies evaluating training, assistive technology, vision rehabilitation and vision restoration. The most frequent aspect of outcome measures is efficiency such as time, distance, speed and percentage of preferred walking speed, followed by obstacle contacts and avoidance, and dis/orientation and veering. Other less commonly used aspects are target identification, safety and social interaction and self-reported outcome measures. Some studies employ sophisticated equipment to capture and analyse O&M performance in a laboratory setting, while others carry out their assessment in real-world indoor or outdoor environments. In the second part of this review, the appropriateness of implementing the identified outcome measures to assess O&M performance in clinical and functional O&M practice is evaluated. Nearly a half of these outcome measures meet all four criteria of face validity (either clinical or functional), responsiveness, reliability and feasibility and have the potential to be implemented in clinical or functional O&M practice. The findings of this review confirm the complicated and dynamic nature of O&M. Multiple measures are required in any evaluation of O&M performance to facilitate holistic assessment of O&M abilities and limitations of each individual. 相似文献
20.