全文获取类型
收费全文 | 1683篇 |
免费 | 289篇 |
国内免费 | 39篇 |
专业分类
耳鼻咽喉 | 13篇 |
儿科学 | 101篇 |
妇产科学 | 19篇 |
基础医学 | 90篇 |
口腔科学 | 26篇 |
临床医学 | 281篇 |
内科学 | 576篇 |
皮肤病学 | 60篇 |
神经病学 | 172篇 |
特种医学 | 279篇 |
外科学 | 185篇 |
综合类 | 31篇 |
预防医学 | 55篇 |
眼科学 | 16篇 |
药学 | 53篇 |
中国医学 | 1篇 |
肿瘤学 | 53篇 |
出版年
2024年 | 9篇 |
2023年 | 52篇 |
2022年 | 13篇 |
2021年 | 27篇 |
2020年 | 90篇 |
2019年 | 12篇 |
2018年 | 88篇 |
2017年 | 69篇 |
2016年 | 68篇 |
2015年 | 60篇 |
2014年 | 94篇 |
2013年 | 109篇 |
2012年 | 44篇 |
2011年 | 35篇 |
2010年 | 76篇 |
2009年 | 108篇 |
2008年 | 41篇 |
2007年 | 44篇 |
2006年 | 42篇 |
2005年 | 25篇 |
2004年 | 13篇 |
2003年 | 11篇 |
2002年 | 14篇 |
2001年 | 29篇 |
2000年 | 12篇 |
1999年 | 24篇 |
1998年 | 80篇 |
1997年 | 95篇 |
1996年 | 78篇 |
1995年 | 68篇 |
1994年 | 49篇 |
1993年 | 52篇 |
1992年 | 26篇 |
1991年 | 14篇 |
1990年 | 25篇 |
1989年 | 52篇 |
1988年 | 42篇 |
1987年 | 26篇 |
1986年 | 20篇 |
1985年 | 20篇 |
1984年 | 16篇 |
1983年 | 9篇 |
1982年 | 14篇 |
1981年 | 14篇 |
1980年 | 14篇 |
1979年 | 8篇 |
1978年 | 8篇 |
1977年 | 9篇 |
1976年 | 10篇 |
1971年 | 8篇 |
排序方式: 共有2011条查询结果,搜索用时 0 毫秒
101.
102.
103.
Vladimír Džavík MD FSCAI Upendra Kaul MD DM FSCAI Guilio Guagliumi MD Bernard Chevalier MD Peter C. Smits MD Marrianne Stuteville BSC Dong Li MSC Krishnankutty Sudhir MD PhD Eberhard Grube MD FSCAI 《Catheterization and cardiovascular interventions》2013,82(3):E163-E172
The aim of this analysis was to analyze outcomes of patients undergoing Xience V EES treatment of bifurcation lesions, a subset in which treatment is particularly challenging. The SPIRIT V Study provided an evaluation of the Xience V everolimus eluting stent (EES) performance in complex patient and lesion population. The SPIRIT V Single Arm Study enrolled 2700 patients with de novo coronary artery lesions suitable to be optimally treated with a maximum of four planned Xience V EES. Lesion evaluation was by visual assessment. The outcomes of the 492 patients undergoing Xience V EES stenting of ≥1 bifurcation lesion were compared to those with no bifurcation lesion treated. Compared to those without bifurcation treatment, patients with bifurcation treatment were more likely to have multi‐vessel disease (49% vs 40%), left main treatment (3.1% vs 0.9%), more lesions treated (1.5 vs 1.3), calcification (36.4% vs 27.5%), and ostial (17.1% vs 8.2%) and angulated lesions (29.3% vs 21.1%), all P < 0.001. The 30‐day composite rate of death, myocardial infarction (MI), target vessel revascularization (TVR) was 4.3% in patients with bifurcation PCI and 2.2% in those with non‐bifurcation PCI (P = 0.017). At 2 years, this composite event rate was 11.3% and 10.0% in these two groups, respectively (P = 0.403). Rates of cardiac death, MI, target lesion revascularization (TLR), TVR, and ARC defined definite or probable stent thrombosis (0.4% vs 0.9%, P = 0.402) were not significantly different between the two groups. Despite greater patient and lesion complexity, treatment of patients with bifurcation lesions using the Xience V EES in the SPIRIT V prospective Single Arm Study was safe and effective, with low overall event rates that were similar to those without bifurcation lesion treatment. © 2013 Wiley Periodicals, Inc. 相似文献
104.
In countries with intermediate or high endemicity for chronic hepatitis B virus (HBV) infection, exacerbations of chronic
hepatitis B (CHB) are common. We studied the clinical, biochemical, and virologic characteristics of patients first presenting
clinically with features of acute icteric hepatitis B, to identify features that might differentiate between acute viral hepatitis
B (AVHB) from first episode of exacerbation of chronic hepatitis (ECHB). We retrospectively analyzed 79 patients (mean age
35.4 ± 14 years; M:F = 60:19) who first presented clinically as AVHB, within 4 weeks of onset of symptoms. Patients who on
follow-up cleared HBsAg and/or did not develop any clinical, radiologic, or histologic evidence of chronic liver disease (CLD)
were categorized as AVHB (group 1). Patients who had persistence of HBsAg and developed clinical, biochemical, radiologic,
or histologic evidence of chronic liver disease were categorized as ECHB (group 2). Forty-nine patients were in group 1 and
30 in group 2. The 2 groups were comparable with respect to prodrome, onset of jaundice, serum bilirubin, ALT, prothrombin
time prolongation, serum albumin, and A/G ratio. Among group 1 patients, 78% had IgM anti-HBc positive in titers > 1:1000;
in group 2, there were negative or positive in titers < 1:1000 in 70% patients (P < .001). Forty-seven of 49 (95.9%) patients in group 1 had HBV-DNA levels < 0.5 pg/mL, whereas 26 of 30 (86.73%) patients
in group 2 had levels > 0.5 pg/mL (P ≤ .001). Quantitative HBV DNA and IgM anti-HBc titers at initial presentation can differentiate patients with a true episode
of acute hepatitis B from patients with first episode of symptomatic exacerbation of chronic hepatitis B. Clinical and biochemical
features do not help in differentiating the two. 相似文献
105.
106.
107.
Cees DM Ruijs Bregje D Onwuteaka-Philipsen Gerrit van der Wal Ad JFM Kerkhof 《BMC palliative care》2009,8(1):16-10
Background
Unbearable suffering is an important issue in end-of-life decisions. However, there has been no systematic, prospective, patient-oriented research which has focused on unbearable suffering, nor is there a suitable measurement instrument. This article describes the methodological development of a quantitative instrument to measure the nature and intensity of unbearable suffering, practical aspects of its use in end-stage cancer patients in general practice, and studies content validity and psychometric properties. 相似文献108.
Unusual association of a unique CAG interruption in 5′ of DM1 CTG repeats with intergenerational contractions and low somatic mosaicism 下载免费PDF全文
Stéphanie Tomé Alexis Bertrand David Geneviève Yann Péréon DM contraction study group Marie Simon Jean‐Paul Bonnefont Guillaume Bassez Geneviève Gourdon 《Human mutation》2018,39(7):970-982
Myotonic dystrophy type 1 (DM1) is a dominant multisystemic disorder associated with high variability of symptoms and anticipation. DM1 is caused by an unstable CTG repeat expansion that usually increases in successive generations and tissues. DM1 family pedigrees have shown that ~90% and 10% of transmissions result in expansions and contractions of the CTG repeat, respectively. To date, the mechanisms of CTG repeat contraction remain poorly documented in DM1. In this report, we identified two new DM1 families with apparent contractions and no worsening of DM1 symptoms in two and three successive maternal transmissions. A new and unique CAG interruption was found in 5′ of the CTG expansion in one family, whereas multiple 5′ CCG interruptions were detected in the second family. We showed that these interruptions are associated with maternal intergenerational contractions and low somatic mosaicism in blood. By specific triplet‐prime PCR, we observed that CTG repeat changes (contractions/expansions) occur preferentially in 3′ of the interruptions for both families. 相似文献
109.
Phylogenetic analysis of human G9P[8] rotavirus strains circulating in Jiangsu,China between 2010 and 2016 下载免费PDF全文
Cheng Xu MD Jianguang Fu DC Jing Ai MD Jun Zhang MD Cheng Liu BD Xiang Huo MD Changjun Bao MD Yefei Zhu DM 《Journal of medical virology》2018,90(9):1461-1470
Rotavirus A (RVA) is the leading cause of acute viral gastroenteritis in children under 5 years of age worldwide. G9P[8] is a common RVA genotype that has been persistently prevalent in Jiangsu, China. To determine the genetic diversity of G9P[8] RVAs, 7 representative G9P[8] strains collected from Suzhou Children’s Hospital between 2010 and 2016 (named JS2010‐JS2016) were analyzed through whole‐genome sequencing. All evaluated strains showed the Wa‐like constellation G9‐P[8]‐I1‐R1‐C1‐M1‐A1‐N1‐T1‐E1‐H1. Furthermore, phylogenetic analysis revealed that the VP7 genes of all strains clustered into lineage G9‐III and G9‐VI. With the exception of strain JS2012 (P[8]‐4), the VP4 sequences of all strains belonged to the P[8]‐3 lineage. Sequencing further revealed that amino acid substitutions were present in the antigenic regions of the VP7 and VP4 genes of all strains. Moreover, there were multiple substitutions in antigenic sites I and II of the nonstructural protein 4 (NSP4) genes, whereas the other NSP genes were relatively conserved. In conclusion, our phylogenetic analysis of these 7 G9P[8] strains suggests that RVA varied across regions and time. Therefore, our findings suggest that continued surveillance is necessary to explore the molecular evolutionary characteristics of RVA for better prevention and treatment of acute viral gastroenteritis. 相似文献
110.
Charlotte Baker Jill Powell Dominic Le Melissa S. Creary Lori-Ann Daley Mary Anne McDonald Charmaine DM. Royal 《Journal of the National Medical Association》2018,110(6):564-573