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991.
Kramer U Rosciano A Pavlovic M Berthoud L Despland JN de Roten Y Caspar F 《Journal of clinical psychology》2011,67(10):1017-1027
Motive-Oriented Therapeutic Relationship (MOTR, also called Complementary Therapeutic Relationship) has already shown itself to be related to therapeutic outcome in several studies. The present study aims to test MOTR in a 4-session Brief Psychodynamic Intervention for patients presenting with major depressive disorder (MDD) and comorbid personality disorder (PD). In total, N = 20 patients were selected; n = 10 had MDD, n = 10 had MDD with comorbid PD. The first therapy session was videotaped and analyzed by means of Plan Analysis and the MOTR scale. Results suggest a differential effect on outcome: only the nonverbal component of MOTR is related to symptomatic change in patients presenting with MDD and comorbid PD; no such effect was found for patients with MDD alone. These results are discussed in line with the generalization and refinement of the conclusions of previous findings on the MOTR. 相似文献
992.
Alessandra Grassi Salles Paula Nunes Toledo Marcus Castro Ferreira 《Aesthetic plastic surgery》2009,33(4):582-590
Background Despite modern reanimation surgical techniques, facial paralysis presents with functional and aesthetic deficits. We evaluated
facial symmetry after treating with botulinum toxin the healthy side of the face of 25 patients with long-standing facial
paralysis who had previously been treated by surgical methods, with 6 months follow-up.
Methods Evaluation consisted of a clinical score, the two subscales of the Facial Disability Index, and surface electromyography.
The mean botulinum toxin dose was 38 ± 5 U (range = 15–69 U).
Results The clinical score showed significant reduction of asymmetry of 48.4% at 1 month and 16.8% after 6 months. The initial result
was a consequence of reduced motion on the treated side combined with better motion on the paralyzed side. At 6 months, the
treated side returned to basal scores. The residual effect seen in symmetry was due to an increase (18%) of motion in the
paralyzed side. There was a significant decrease in the action potential of muscles on the nonparalyzed side 1 month post
injection but completely reverted after 6 months. The Physical Function Index increased, but not significantly. The Social/Well-Being
Function Index showed a significant increase at 6 months compared to pretreatment.
Conclusion The proposed treatment improved facial symmetry for up to 6 months. Even after the end of the clinical effect of the drug,
the paralyzed side’s clinical score was 18% higher than pretreatment, with an increased quality of life. 相似文献
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994.
995.
Marcello Deriu MD Giovanni Cossu MD Andrea Molari MD Daniela Murgia MD Alessandra Mereu BS PhD Paola Ferrigno MD Davide Manca MD Paolo Contu MD PhD Maurizio Melis MD 《Movement disorders》2009,24(5):697-701
The aim of our study was to explore restless legs syndrome (RLS) frequency in multiple sclerosis (MS)‐patients and establish whether RLS could be a symptom of MS. Over a period of 1 year, we consecutively enrolled 202 MS‐patients and 212 healthy controls, matched for sex and age, in a case‐control study. All of them filled in a structured questionnaire according to IRLSSG criteria. Those patients who fit the diagnostic criteria were subsequently examined by a neurologist to verify the effective presence of RLS. A total of 91 MS‐patients (45%) responded positively to the questionnaires. The diagnosis of RLS was carried out in 29subjects (14.4%). Among the healthy controls, a definite diagnosis of RLS was achieved only in 6 subjects (2.8%). The risk of MS patients to present RLS was significantly higher (OR.5.76 P:0.00002) than the general population. None of them was affected by other medical conditions related to RLS developing. The 62 remaining patients presented numbness and weakness of the legs not suggestive of RLS. Our findings confirm a significant correlation between MS and RLS. In our opinion, MS must be definitively included among RLS causes. © 2008 Movement Disorder Society 相似文献
996.
Elisabetta Crocetti William W. Hale Alessandra Fermani Quinten Raaijmakers Wim Meeus 《Journal of anxiety disorders》2009,23(6):824-829
In this study examination is given to the psychometric properties of the Italian version of the Screen for Child Anxiety Related Emotional Disorders (SCARED) in a large community sample of adolescents. Additionally, a comparison was made between the anxiety scores of this Italian adolescent cohort (N = 1975) and a comparative Dutch adolescent cohort (N = 1115).Findings revealed that a five-factor structure of the SCARED applied not only to the Italian adolescents from the general community, but also to boys and girls, and to early and middle adolescents. Moreover, sex and age differences on anxiety scores within the Italian sample were found to be consistent with previous studies of adolescent anxiety disorders. Finally, Italian adolescents reported higher anxiety scores than their Dutch peers.Findings of this study highlight that the SCARED is a valid screening instrument to rate anxiety symptoms of Italian adolescents. 相似文献
997.
Alessandra Bizzarro Davide Seripa Adele Acciarri Maria Giovanna Matera Alberto Pilotto Francesco Danilo Tiziano Christina Brahe Carlo Masullo 《European journal of human genetics : EJHG》2009,17(7):938-945
The single nucleotide polymorphisms (SNPs) rs449647, rs769446 and rs405509 in the promoter region of the APOE gene have been variously suggested to be ɛ4-independent risk factors for Alzheimer''s disease (AD). A previous Italian study found that the rs449647 was significantly associated with late-onset AD. The aim of this study was to verify whether these APOE promoter SNPs are genetic risk factors for AD and to investigate their interaction with the common APOE polymorphism. A total of 169 clinically diagnosed AD patients and 99 cognitively intact age-matched controls were included in the study. Significant associations with AD independent from sex, age and APOE/ɛ4 status were found for rs449647 A/A and rs405509 G/G genotypes (positive), and rs449647 A/T and rs405509 T/T genotypes (negative). Haplotype frequency estimation at the APOE locus showed significant associations for the ATG4, ATT4 and ACG3 (positive) and ATT2, ATT3 and TCG3 (negative) haplotypes. Therefore this study confirms the role of the rs449647 A/A genotype as risk factor for AD in Italy and suggests that promoter genotypes and APOE haplotypes might have a complex function in AD-associated genetic risk factors. 相似文献
998.
999.
Martina Cesani Alessia Capotondo Tiziana Plati Lucia Sergi Sergi Francesca Fumagalli Maria Grazia Roncarolo Luigi Naldini Giancarlo Comi Maria Sessa Alessandra Biffi 《Human mutation》2009,30(10):E936-E945
Metachromatic Leukodystrophy (MLD) is a rare inherited lysosomal storage disorder caused by the deficiency of Arylsulfatase A (ARSA). The disease manifests itself with a broad spectrum of clinical variants, all characterized by progressive neurodegeneration in the central and peripheral nervous systems. The correlation between mutations in the ARSA gene, residual enzymatic activity associated with the mutated alleles and patients' phenotype, which has been extensively drawn for common ARSA mutations, has recently been expanded to rare ones. In this context, functional studies on the rare allelic variances acquire particular relevance for patients' prognostic evaluation. Here we have characterized eight newly identified ARSA mutations, through lentiviral vector‐based expression studies on cell lines and ARSA defective murine fibroblasts. In each case, the residual activity associated with the new mutant allele correlates well with the patient's phenotype. Therefore, our results confirm the importance of functional characterization of mutant alleles for a precise genotype‐based classification and definition of prognosis in MLD patients, which is particularly relevant for pre‐symptomatic diagnosis. © 2009 Wiley‐Liss, Inc. 相似文献
1000.
Stefano Mora Laura Cafarelli Paola Erba Maria Puzzovio Ilaria Zamproni Vania Giacomet Alessandra Viganò 《Journal of bone and mineral metabolism》2009,27(6):721-726
Bones undergo intensive modeling during growth, a process involving both formation and resorption processes. Bone formation
can be accurately monitored by measurements of bone-specific alkaline phosphatase (BAP) in serum. The lack of appropriate
reference values has hampered the use of BAP in pediatric subjects. The purposes of the present study were to verify the effect
of age, gender, and puberty on BAP concentration in healthy children, and to generate reference curves. Morning blood samples
were collected from 239 healthy children and adolescents (113 boys), aged 4.5–20.9 years. Anthropometric measurements and
pubertal stage were recorded. Blood samples were also obtained from 37 healthy young adults (13 men), aged 21.5–30.2 years.
BAP concentration varied significantly with age, showing a peak at age 10–12 years in girls and 12–14 years in boys. Prepubertal
concentration of BAP was six- to sevenfold higher than in healthy adults. We observed significantly higher BAP values at the
beginning of puberty (stage II) compared to prepubertal stage in both sexes. The effect of puberty was independent from age
and gender. We demonstrated that BAP serum concentration varies with age in children and adolescents, and we provided equations
to calculate reference values. Because BAP concentrations vary markedly according to the pubertal stage, the values of BAP
obtained in single patients should be compared to reference considering not only age and sex, but also the stage of pubertal
development. 相似文献