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61.
62.
拉萨地区高原肺水肿经颅多普勒21例分析 总被引:1,自引:0,他引:1
目的:通过经颅多普勒(TCD)检测,了解高原肺水肿(HAPE)患者颅内脑底动脉环上的主要动脉血流动力学及各血流的生理参数,为高原肺水肿的诊断及治疗提供一些参考.方法:将已确诊的HAPE患者,与颞窗通过低频脉冲多普勒(2MHZ),获得颅内脑底动脉环上的主要动脉的多普勒超声频移信号,进行TCD检测.结果:TCD检测后了解到颅内脑底动脉环上的主要动脉:颈内动脉末梢、大脑中动脉、大脑前动脉血流速度(收缩期血流速度,平均血流速度,舒张末期血流速度)与正常人的TCD测值相比明显增快,但舒张末期血流速度(VE )增快较收缩期血流速度(VP )不明显,故频谱仍为低阻波形,搏动指数(PI)、收缩期血流速度与舒张末期血流速度的比值(S/D)正常,阻力指数有所降低.结论:经TCD检测可知高原肺水肿患者在高原(在低氧环境下),颅内主要脑血管扩张,脑血流量增加即颈内动脉系统的MCA,ACA,PICA血流速度(Vs,Vm,Vd)增快,通过TCD检查可为高原医生早期诊断及治疗提供参考. 相似文献
63.
64.
过敏康Ⅱ号胶囊对AsAb阳性大鼠睾丸Bcl-2、Bax表达影响的实验研究 总被引:1,自引:0,他引:1
目的观察过敏康Ⅱ号胶囊对AsAb阳性大鼠睾丸Bcl-2、Bax表达的影响。方法选取健康成年雄性SD大鼠60只,按体重随机分为正常组,模型组,对照组,高、中、低剂量组,每组10只。采用主动免疫法建立血清抗精子抗体(AsAb)阳性动物模型10只,灌胃给药,免疫组化方法观察药物对AsAb阳性大鼠睾丸Bcl-2、Bax表达的影响。结果过敏康Ⅱ号高剂量组睾丸生精细胞和精子Bcl-2表达的平均吸光值显著高于模型组(P〈0.01),而Bax表达的平均吸光值显著低于模型组(P〈0.01)。结论调节睾丸Bcl-2、Bax的表达是过敏康Ⅱ号清除或抑制AsAb起治疗作用的机制之一。 相似文献
65.
OBJECTIVE: To study the expression of neuron-specific enolase (NSE) and olfactory marker protein (OMP) in the developing olfactory mucosa of human fetuses. METHOD: The expression of NSE and OMP in the olfactory mucosa of 6 human fetuses (12, 16, 20, 24, 28 and 34 weeks) was studied using the technique of immunohistochemistry. RESULTS: NSE immunological positive reactions were seen in all 6 fetal mucosa from gestational 12 (G12) to G34, with plenty of positive-stained dual-pole neuron cells. At G12, the positive cells aligned tightly, the cell bodies were localized in the lower portion of olfactory epithelium and the positive-stained area occupied upper 2/3 of fetal nasal mucosa. With the development, the positive cells gradually became multilayer, but the density and the relative area of positive-cells reduced. At G34, the positive cells were located only in upper 1/3 of nasal mucosa. OMP-positive reactions were localized in a few dual-pole neurons at G12, the number was much less than NSE-positive cells in the same fetus. With the development, the OMP-positive cells gradually increased with most of the cell bodies located in the upper portion of epithelium, but number still relatively less than the NSE-positive cells at the same age. CONCLUSION: At G12, there were lots of olfactory neuron in the olfactory mucosa and only a few olfactory neurons had became mature. With the development, the olfactory epithelial area reduced but the number of mature olfactory neurons increased. At the last trimester, fetal olfactory sensor was almost matured. 相似文献
66.
Stéphane Aubert Roland Henaine Olivier Raisky Nicolas Chavanis Jacques Robin René Ecochard Jean Ninet 《European journal of cardio-thoracic surgery》2005,28(2):223-228
OBJECTIVE: We consider the short- and long-term outcomes of the repair of the isolated partial atrioventricular (AV) septal defect to determine the role played by the atypical forms on the initial AV valve replacement and on the risk of reoperation. METHODS: Two hundred and eight patients underwent an operation for this malformation between 1974 and 2001. Clinical and echocardiographic examinations were performed on all patients, the AV valve regurgitation was graded from 1 to 4 and a residual interatrial shunt was sought. Median age at the intervention was 5.8 years (3 months to 67 years). RESULTS: Median follow-up time was 7.5 years (range 0-22.6 years). The cumulative 30-day, 5- and 20-year survival rates were 96.5, 95.4 and 94.6%, respectively. AV valve replacement was associated with a high mortality (P<0.001). A reoperation was performed on 12 patients (5.7%) including six patients within less than a 30-day period, especially to repair residual AV valve regurgitation. We performed four AV valve repairs by annuloplasty and six AV valve replacements. Two patients who had initially undergone an AV valve replacement underwent a reoperation for valve thrombosis. The cumulative 30-day, 5- and 20-year rates of freedom from reoperation were 96.5, 93.6 and 83%, respectively. An atypical form was present in 24 patients (11.5%) and was a risk factor for initial AV valve replacement (P<0.001) and for reoperation (P<0.001). A complete AV block occurred in 13 patients (6.2%), all of them within a 30-day period. The AV valve replacement was a high risk factor for a complete AV block (P<0.001). At the end of our study 180 patients (96%) were in NYHA I and 8 in NYHA II. CONCLUSIONS: The morbi-mortality of the isolated partial AV septal defect is primarily perioperative and is linked with the presence of an atypical form of the lesion. This atypical form was the main reason for reoperation for AV valve regurgitation. The AV valve replacement was associated with a high mortality and with the occurrence of complete AV block. Using a standardized technique, the AV septal defect can be repaired with excellent long-term clinical and echographic results. 相似文献
67.
目的探讨弥漫性大B细胞淋巴瘤(DLBCL)组织中CD40L表达与DLBCL预后间的关系及意义。方法免疫组织化学法检测27例弥漫性大B细胞淋巴瘤、20例淋巴结反应性增生组织中CD40L的表达。结果(1)DLBCL中CD40L过度阳性率(25.93%)显著低于淋巴结反应性增生(63.64%),P〈0.05。(2)CD40L在Ⅲ、Ⅳ期DLBCL过度阳性率(14.29%)低于Ⅰ、Ⅱ期(38.46%),P〈0.05。CD40L过度阳性率在有结外浸润DLBCL(11.76%)低于无有结外浸润DLBCL(40%),P〈0.05。(3)DLBCL患者CD40L的过度阳性率与远处转移、临床分期均显著相关,P〈0.05。结论(1)CD40L过度阳性率与结外器官浸润及临床分期密切相关,其可能作为判断DLBCL侵袭性及预后的指标。(2)DLBCL中CD40L表达的减少可能是影响其发病的因素之一。 相似文献
68.
69.
Partial splenic embolization for hypersplenism concomitant with or after arterial embolization of hepatocellular carcinoma in 30 patients 总被引:15,自引:0,他引:15
Ming-Jun Han Han-Guo Zhao Ke Ren Dong-Chun Zhao Ke Xu Xi-Tong Zhang 《Cardiovascular and interventional radiology》1997,20(2):125-127
Purpose To study the value of partial splenic embolization (PSE) for the treatment of hypersplenism in patients undergoing embolization
of hepatocellular carcinoma (HCC).
Methods Transcatheter hepatic arterial embolization (THAE) combined with PSE was performed in 30 patients with HCC complicating liver
cirrhosis, portal hypertension, and hypersplenism. Gelfoam sponge was used as the embolic material for PSE and limited to
100–150 pieces.
Results More than 50% of splenic parenchyma was infarcted in 27 patients. Leukopenia and thrombocytopenia were corrected by PSE in
25 of 27 patients with hypersplenism. In 26 patients with esophageal varices, including 5 patients with bleeding, no rebleeding
occurred during a 6–17 month follow-up. Hypersplenism was not corrected in 2 of 3 patients whose infarcted splenic parenchyma
was less than 50%. No splenic abscesses or other severe complications were observed. Of the 30 patients treated, 19 are still
alive after 1 year.
Conclusions THAE combined with PSE is a safe and effective measure for patients with HCC. 相似文献
70.
研究目的探讨苯酞类天然产物的合成方法及其生物活性。研究方法以邻苯二甲酐为底物,首先引入丁烯基,再进行烯丙位氧化,制得目标化合物。结果通过丁基锂反应,得到了具有药物活性的丁烯基苯酞,然后利用SeO2烯丙位氧化,首次合成了Z-3-(2-羟基丁烯基)苯酞。结论此合成方法原料易得,方法简便,为苯酞类化合物的合成研究提供了一个新的途径。 相似文献