全文获取类型
收费全文 | 390篇 |
免费 | 28篇 |
国内免费 | 2篇 |
专业分类
儿科学 | 7篇 |
妇产科学 | 6篇 |
基础医学 | 34篇 |
口腔科学 | 1篇 |
临床医学 | 44篇 |
内科学 | 110篇 |
皮肤病学 | 8篇 |
神经病学 | 19篇 |
特种医学 | 9篇 |
外科学 | 61篇 |
综合类 | 8篇 |
预防医学 | 34篇 |
眼科学 | 10篇 |
药学 | 35篇 |
中国医学 | 8篇 |
肿瘤学 | 26篇 |
出版年
2023年 | 4篇 |
2022年 | 29篇 |
2021年 | 26篇 |
2020年 | 11篇 |
2019年 | 32篇 |
2018年 | 30篇 |
2017年 | 9篇 |
2016年 | 10篇 |
2015年 | 8篇 |
2014年 | 13篇 |
2013年 | 20篇 |
2012年 | 30篇 |
2011年 | 28篇 |
2010年 | 11篇 |
2009年 | 11篇 |
2008年 | 13篇 |
2007年 | 12篇 |
2006年 | 10篇 |
2005年 | 14篇 |
2004年 | 14篇 |
2003年 | 18篇 |
2002年 | 11篇 |
2001年 | 4篇 |
2000年 | 5篇 |
1999年 | 4篇 |
1997年 | 1篇 |
1996年 | 2篇 |
1995年 | 1篇 |
1993年 | 1篇 |
1992年 | 5篇 |
1991年 | 3篇 |
1990年 | 5篇 |
1989年 | 4篇 |
1988年 | 2篇 |
1987年 | 3篇 |
1986年 | 7篇 |
1985年 | 4篇 |
1983年 | 2篇 |
1981年 | 1篇 |
1979年 | 1篇 |
1976年 | 1篇 |
排序方式: 共有420条查询结果,搜索用时 15 毫秒
11.
Arman Qamar Muthiah Vaduganathan Norton J. Greenberger Robert P. Giugliano 《Journal of the American College of Cardiology》2018,71(19):2162-2175
Patients with liver disease are at increased risks of both thrombotic and bleeding complications. Many have atrial fibrillation (AF) or venous thromboembolism (VTE) necessitating oral anticoagulant agents (OACs). Recent evidence has contradicted the assumption that patients with liver disease are “auto-anticoagulated” and thus protected from thrombotic events. Warfarin and non–vitamin K–antagonist OACs have been shown to reduce thrombotic events safely in patients with either AF or VTE. However, patients with liver disease have largely been excluded from trials of OACs. Because all currently approved OACs undergo metabolism in the liver, hepatic dysfunction may cause increased bleeding. Thus, the optimal anticoagulation strategy for patients with AF or VTE who have liver disease remains unclear. This review discusses pharmacokinetic and clinical studies evaluating the efficacy and safety of OACs in patients with liver disease and provides a practical, clinically oriented approach to the management of OAC therapy in this population. 相似文献
12.
Antibody to cardiolipin, lupus anticoagulant, and fetal death 总被引:9,自引:0,他引:9
We compared the concordance and predictive powers of activated partial thromboplastin time (APTT) and of IgG and IgM antibody to cardiolipin (aCL), for predicting fetal death in 50 pregnant women with systemic lupus erythematosus (SLE) and/or lupus anticoagulant. Overall concordance of any abnormal determination of aCL during pregnancy with any abnormal determination of APTT was 76% (0.05 less than p less than 0.10). Fetal death occurred in 6/12 (50%) of patients with high APTT compared to 5/20 (16%) of patients with low APTT; fetal death occurred in 10/13 (77%) of patients with abnormal aCL and in 2/37 (5%) of patients with normal aCL. Sensitivity for predicting fetal death was .55 for APTT and .85 for aCL; specificity was .81 for APTT and .92 for aCL. Abnormalities of APTT and aCL are sufficiently frequently discordant to prevent equation of the 2 assays. ACL is the better assay for predicting fetal death. 相似文献
13.
Melissa C. Caughey PhD Muthiah Vaduganathan MD MPH Sameer Arora MD MPH Arman Qamar MD MPH Robert J. Mentz MD Patricia P. Chang MD MHS Clyde W. Yancy MD Stuart D. Russell MD Sanjiv J. Shah MD Wayne D. Rosamond PhD Ambarish Pandey MD MSCS 《Journal of the American Geriatrics Society》2021,69(5):1309-1318
14.
Inayat Ur Rehman Raheel Ahmed Aziz Ur Rahman David Bin Chia Wu Syed Munib Yasar Shah Nisar Ahmad Khan Ateeq Ur Rehman Learn Han Lee Kok Gan Chan Tahir Mehmood Khan 《Medicine》2021,100(21)
Background:Chronic kidney disease (CKD)-associated pruritus (CKD-aP) contributes to poor quality of life, including reduced sleep quality and poor sleep quality is a source of patient stress and is linked to lower health-related quality of life. This study aimed to investigate the effectiveness of zolpidem 10 mg and acupressure therapy on foot acupoints to improve the sleep quality and overall quality of life among hemodialysis patients suffering from CKD-aP.Method:A multicenter, prospective, randomized, parallel-design, open label interventional study to estimate the effectiveness of zolpidem (10 mg) oral tablets versus acupressure on sleep quality and quality of life in patients with CKD-aP on hemodialysis. A total of 58 hemodialysis patients having sleep disturbance due to CKD-aP completed the entire 8-week follow-up. The patients were divided into a control (acupressure) group of 28 patients and an intervention (zolpidem) group of 30 patients.Results:A total of 58 patients having CKD-aP and sleep disturbance were recruited. In the control group there was a reduction in the PSQI score with a mean ± SD from 12.28 ± 3.59 to 9.25 ± 3.99, while in the intervention group the reduction in PSQI score with a mean ± SD was from 14.73 ± 4.14 to 10.03 ± 4.04 from baseline to endpoint. However, the EQ5D index score and EQ-visual analogue scale (VAS) at baseline for the control group with a mean ± SD was 0.49 ± 0.30 and 50.17 ± 8.65, respectively, while for the intervention group the values were 0.62 ± 0.26 and 47.17 ± 5.82, respectively. The mean EQ5D index score in the control group improved from 0.49 ± 0.30 to 0.53 ± 0.30, but in the intervention group there was no statistical improvement in mean EQ5D index score from 0.62 ± 0.26 to 0.62 ± 0.27 from baseline to week 8. The EQ 5D improved in both groups and the EQ-VAS score was 2.67 points higher at week 8 as compared to baseline in the control group, while in the intervention group the score was 3.33 points higher at week 8 as compared to baseline. Comparing with baseline, the PSQI scores were significantly reduced after week 4 and week 8 (P = < .001). Furthermore, at the end of the study, the PSQI scores were significantly higher in the control as compared to the intervention group (P = .012).Conclusion:An improvement in sleep quality and quality of life among CKD-aP patients on hemodialysis has been observed in both the control and intervention groups. Zolpidem and acupressure safety profiling showed no severe adverse effect other that drowsiness, nausea and daytime sleeping already reported in literature of zolpidem. 相似文献
15.
Identification of novel CYP1B1 gene mutations in patients with primary congenital and primary open‐angle glaucoma
下载免费PDF全文
![点击此处可从《Clinical & experimental ophthalmology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
16.
17.
18.
19.
We present an unusual complication caused by a dialysis catheter inserted through the internal jugular vein into the central venous system. The 49-year-old male patient developed a right atrial thrombus, which became infected with Staphylococcus aureus, resulting in septic pulmonary embolism and septicemic shock. The thrombus was excised on cardiopulmonary bypass. The patient made an uneventful recovery. 相似文献
20.