全文获取类型
收费全文 | 2554466篇 |
免费 | 199000篇 |
国内免费 | 4164篇 |
专业分类
耳鼻咽喉 | 36289篇 |
儿科学 | 85353篇 |
妇产科学 | 73909篇 |
基础医学 | 368371篇 |
口腔科学 | 74530篇 |
临床医学 | 223376篇 |
内科学 | 495459篇 |
皮肤病学 | 54626篇 |
神经病学 | 203992篇 |
特种医学 | 100932篇 |
外国民族医学 | 793篇 |
外科学 | 390738篇 |
综合类 | 59787篇 |
现状与发展 | 4篇 |
一般理论 | 807篇 |
预防医学 | 195422篇 |
眼科学 | 59593篇 |
药学 | 193908篇 |
3篇 | |
中国医学 | 4782篇 |
肿瘤学 | 134956篇 |
出版年
2018年 | 23880篇 |
2015年 | 23928篇 |
2014年 | 32989篇 |
2013年 | 50320篇 |
2012年 | 68600篇 |
2011年 | 73013篇 |
2010年 | 43042篇 |
2009年 | 40893篇 |
2008年 | 70140篇 |
2007年 | 74922篇 |
2006年 | 76193篇 |
2005年 | 74278篇 |
2004年 | 72505篇 |
2003年 | 69695篇 |
2002年 | 68522篇 |
2001年 | 115764篇 |
2000年 | 119273篇 |
1999年 | 101310篇 |
1998年 | 28509篇 |
1997年 | 25759篇 |
1996年 | 25852篇 |
1995年 | 24859篇 |
1994年 | 23417篇 |
1993年 | 21986篇 |
1992年 | 83445篇 |
1991年 | 81586篇 |
1990年 | 80229篇 |
1989年 | 77732篇 |
1988年 | 72351篇 |
1987年 | 71372篇 |
1986年 | 67948篇 |
1985年 | 65281篇 |
1984年 | 49005篇 |
1983年 | 42574篇 |
1982年 | 25127篇 |
1981年 | 22329篇 |
1980年 | 21045篇 |
1979年 | 46968篇 |
1978年 | 32867篇 |
1977年 | 27990篇 |
1976年 | 26478篇 |
1975年 | 28413篇 |
1974年 | 34206篇 |
1973年 | 33010篇 |
1972年 | 30915篇 |
1971年 | 28877篇 |
1970年 | 26758篇 |
1969年 | 25302篇 |
1968年 | 23447篇 |
1967年 | 21015篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
941.
G. H. M. B. Van Rens 《Documenta ophthalmologica. Advances in ophthalmology》1988,70(2-3):205-208
The Q-switched neodymium-YAG laser was used via a transconjunctival approach to reopen a failed filtering bleb, 6 weeks after a primarily successful trabeculectomy had failed. One day after treatment, the intraocular pressure had decreased from 34 mm Hg to 17 mm Hg, and a conjunctival bleb had reformed. 相似文献
942.
943.
Although extracellular matrix (ECM) glycoproteins play important roles in neural development, their levels are generally believed to decrease in the adult brain. Immunohistochemical analysis indicates that the anti-adhesive ECM glycoprotein SPARC/osteonectin, which contains a follistatin ‘module’, is expressed in the adult rabbit nervous system. In the cerebellum, SPARC is present in Bergmann glia, with a strong signal along their radial fibres. SPARC, while enriched in membrane fractions, is not a transmembrane protein. In the hippocampus, colocalization of SPARC is observed in cells which express the astrocytic marker GFAP. The expression of SPARC by a subset of astrocytes, particularly in synaptic enriched areas, suggests a continuing role for the ECM in the adult brain. 相似文献
944.
Juin Fok-Seang Linda C. Smith-Thomas Sally Meiners Elizabeth Muir Jian-Sheng Du Elizabeth Housden Alan R. Johnson Andreas Faissner Herbert M. Geller Roger J. Keynes John H. Rogers James W. Fawcett 《Brain research》1995,689(2):207
The adult mammalian central nervous system (CNS) lacks the capacity to support axonal regeneration. There is increasing evidence to suggest that astrocytes, the major glial population in the CNS, may possess both axon-growth promoting and axon-growth inhibitory properties and the latter may contribute to the poor regenerative capacity of the CNS. In order to examine the molecular differences between axon-growth permissive and axon-growth inhibitory astrocytes, a panel of astrocyte cell lines exhibiting a range of axon-growth promoting properties was generated and analysed. No clear correlation was found between the axon-growth promoting properties of these astrocyte cell lines with: (i) the expression of known neurite-outgrowth promoting molecules such as laminin, fibronectin andN-cadherin; (ii) the expression of known inhibitory molecules such tenascin and chondroitin sulphate proteoglycan; (iii) plasminogen activator and plasminogen activator inhibitor activity; and (iv) growth cone collapsing activity. EM studies on aggregates formed from astrocyte cell lines, however, revealed the presence of an abundance of extracellular matrix material associated with the more inhibitory astrocyte cell lines. When matrix deposited by astrocyte cell lines was assessed for axon-growth promoting activity, matrix from permissive lines was found to be a good substrate, whereas matrix from the inhibitory astrocyte lines was a poor substrate for neuritic growth. Our findings, taken together, suggest that the functional differences between the permissive and the inhibitory astrocyte cell lines reside largely with the ECM. 相似文献
945.
A. Schettino C. Giordano A. Parisi G. Calabrò 《Journal of the European Academy of Dermatology and Venereology》1995,4(2):153-154
We describe a mild form of drug-induced pemphigus in a woman with essential arterial hypertension treated with captopril. Complete recovery was observed three weeks after the therapy had been discontinued. 相似文献
946.
947.
New latex reagent using monoclonal antibodies to capsular polysaccharide for reliable identification of both oxacillin-susceptible and oxacillin-resistant Staphylococcus aureus. 总被引:5,自引:5,他引:0 下载免费PDF全文
J M Fournier A Bouvet D Mathieu F Nato A Boutonnier R Gerbal P Brunengo C Saulnier N Sagot B Slizewicz et al. 《Journal of clinical microbiology》1993,31(5):1342-1344
A new latex agglutination test (Pastorex Staph-Plus, Sanofi Diagnostics Pasteur), consisting of a mixture of latex particles coated with fibrinogen and immunoglobulin G for the detection of clumping factor and protein A and latex particles sensitized with monoclonal antibodies directed to Staphylococcus aureus serotype 5 and 8 capsular polysaccharides, was compared with three commercially available rapid agglutination methods for the identification of 220 isolates of S. aureus (61 oxacillin resistant) and 128 isolates of coagulase-negative staphylococci. The sensitivity for identification of S. aureus was high with the Pastorex Staph-Plus test (98.6%) compared with those of the other tests, which ranged from 91.8 to 84.5%. Test sensitivities for the identification of oxacillin-resistant S. aureus were as follows: Pastorex Staph-Plus, 95.1%; Pastorex Staph, 73.8%; Staphyslide, 72.1%; and StaphAurex, 49.2%. 相似文献
948.
Pharmacokinetics and pharmacodynamics of benazepril hydrochloride in patients with major proteinuria
Ch. Schweizer G. Kaiser W. Dieterle J. Mann 《European journal of clinical pharmacology》1993,44(5):463-466
Summary We have investigated whether the pharmacokinetics and pharmacodynamics of the ACE inhibitor benazepril hydrochloride are altered with proteinuria by studying 8 patients with major proteinuria of different causes who were given a single dose of 10 mg p.o.The maximum plasma concentration of benazepril was found between 0.5 and 2 h after dosing (median 1 h). Its elimination was almost complete within 6 h. Peak plasma levels of benazeprilat, the active metabolite of benazepril, were observed between 1 and 6 h (median 2.5 h). The elimination of benazeprilat from plasma was biphasic, with mean initial and terminal half-lives of 3.0 and 17.3 h, respectively. On average, the pharmacokinetic parameters of benazepril and benazeprilat in the patients did not differ from those in a historical control group of healthy volunteers, but intersubject variability in the AUC and half-lives of benazeprilat was greater in the patients.Plasma ACE was completely inhibited from 1.5 to 6 h after dosing, and at 48 h the mean inhibition was still 42 %. Plasma renin showed substantial intersubject variation. Mean supine blood pressure (systolic/diastolic) was reduced from baseline by a maximum of 18/13 mm Hg at 6 h. Proteinuria was diminished after benazepril in 7 patients.In conclusion, the results of this study suggest that proteinuria in the nephrotic range does not require a change in benazepril dosage. 相似文献
949.
950.