全文获取类型
收费全文 | 2564958篇 |
免费 | 199707篇 |
国内免费 | 4177篇 |
专业分类
耳鼻咽喉 | 36402篇 |
儿科学 | 85672篇 |
妇产科学 | 74273篇 |
基础医学 | 369726篇 |
口腔科学 | 74667篇 |
临床医学 | 224741篇 |
内科学 | 497608篇 |
皮肤病学 | 54746篇 |
神经病学 | 204879篇 |
特种医学 | 101184篇 |
外国民族医学 | 793篇 |
外科学 | 391694篇 |
综合类 | 59974篇 |
现状与发展 | 4篇 |
一般理论 | 816篇 |
预防医学 | 196841篇 |
眼科学 | 59832篇 |
药学 | 194584篇 |
4篇 | |
中国医学 | 4791篇 |
肿瘤学 | 135611篇 |
出版年
2018年 | 24032篇 |
2015年 | 24052篇 |
2014年 | 33205篇 |
2013年 | 50653篇 |
2012年 | 69020篇 |
2011年 | 73482篇 |
2010年 | 43341篇 |
2009年 | 41134篇 |
2008年 | 70556篇 |
2007年 | 75363篇 |
2006年 | 76574篇 |
2005年 | 74709篇 |
2004年 | 72933篇 |
2003年 | 70112篇 |
2002年 | 68873篇 |
2001年 | 115977篇 |
2000年 | 119516篇 |
1999年 | 101516篇 |
1998年 | 28628篇 |
1997年 | 25850篇 |
1996年 | 25933篇 |
1995年 | 24961篇 |
1994年 | 23492篇 |
1993年 | 22069篇 |
1992年 | 83608篇 |
1991年 | 81760篇 |
1990年 | 80398篇 |
1989年 | 77884篇 |
1988年 | 72519篇 |
1987年 | 71519篇 |
1986年 | 68081篇 |
1985年 | 65395篇 |
1984年 | 49110篇 |
1983年 | 42653篇 |
1982年 | 25173篇 |
1981年 | 22365篇 |
1980年 | 21107篇 |
1979年 | 47039篇 |
1978年 | 32949篇 |
1977年 | 28057篇 |
1976年 | 26553篇 |
1975年 | 28477篇 |
1974年 | 34273篇 |
1973年 | 33084篇 |
1972年 | 30973篇 |
1971年 | 28943篇 |
1970年 | 26823篇 |
1969年 | 25348篇 |
1968年 | 23513篇 |
1967年 | 21056篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
101.
102.
T. Wu L. G. Trahair M. J. Bound C. F. Deacon M. Horowitz C. K. Rayner K. L. Jones 《Diabetic medicine》2015,32(5):595-600
103.
104.
105.
106.
Feasibility and Diagnostic Potential of Pulmonary Transit Time Measurement by Contrast Echocardiography: A Pilot Study
下载免费PDF全文
![点击此处可从《Echocardiography (Mount Kisco, N.Y.)》网站下载免费的PDF全文](/ch/ext_images/free.gif)
107.
Weiyu Ye Anna Olsson-Brown Robert A. Watson Vincent T. F. Cheung Robert D. Morgan Isar Nassiri Rosalin Cooper Chelsea A. Taylor Umair Akbani Oliver Brain Rubeta N. Matin Nicholas Coupe Mark R. Middleton Mark Coles Joseph J. Sacco Miranda J. Payne Benjamin P. Fairfax 《British journal of cancer》2021,124(10):1661
Background Immune checkpoint blockers (ICBs) activate CD8+ T cells, eliciting both anti-cancer activity and immune-related adverse events (irAEs). The relationship of irAEs with baseline parameters and clinical outcome is unclear.Methods Retrospective evaluation of irAEs on survival was performed across primary (N = 144) and secondary (N = 211) independent cohorts of patients with metastatic melanoma receiving single agent (pembrolizumab/nivolumab—sICB) or combination (nivolumab and ipilimumab—cICB) checkpoint blockade. RNA from pre-treatment and post-treatment CD8+ T cells was sequenced and differential gene expression according to irAE development assessed.Results 58.3% of patients developed early irAEs and this was associated with longer progression-free (PFS) and overall survival (OS) across both cohorts (log-rank test, OS: P < 0.0001). Median survival for patients without irAEs was 16.6 months (95% CI: 10.9–33.4) versus not-reached (P = 2.8 × 10−6). Pre-treatment monocyte and neutrophil counts, but not BMI, were additional predictors of clinical outcome. Differential expression of numerous gene pathway members was observed in CD8+ T cells according to irAE development, and patients not developing irAEs demonstrating upregulated CXCR1 pre- and post-treatment.Conclusions Early irAE development post-ICB is associated with favourable survival in MM. Development of irAEs is coupled to expression of numerous gene pathways, suggesting irAE development in-part reflects baseline immune activation.Subject terms: Immunotherapy, Melanoma 相似文献
108.
109.
110.
Marcel Toussaint Raymond J. Gilles Noura Azzabou Benjamin Marty Alexandre Vignaud Andreas Greiser Pierre G. Carlier 《Medicine》2015,94(43)
Delayed contrast enhancement after injection of a gadolinium-chelate (Gd-chelate) is a reference imaging method to detect myocardial tissue changes. Its localization within the thickness of the myocardial wall allows differentiating various pathological processes such as myocardial infarction (MI), inflammatory myocarditis, and cardiomyopathies. The aim of the study was first to characterize benign myocarditis using quantitative delayed-enhancement imaging and then to investigate whether the measure of the extracellular volume fraction (ECV) can be used to discriminate between MI and myocarditis.In 6 patients with acute benign myocarditis (32.2 ± 13.8 year-old, subepicardial late gadolinium enhancement [LGE]) and 18 patients with MI (52.3 ± 10.9 year-old, subendocardial/transmural LGE), myocardial T1 was determined using the Modified Look-Locker Imaging (MOLLI) sequence at 3 Tesla before and after Gd-chelate injection. T1 values were compared in LGE and normal regions of the myocardium. The myocardial T1 values were normalized to the T1 of blood, and the ECV was calculated from T1 values of myocardium and blood pre- and post-Gd injection.In both myocarditis and MI, the T1 was lower in LGE regions than in normal regions of the left ventricle. T1 of LGE areas was significantly higher in myocarditis than in MI (446.8 ± 45.8 vs 360.5 ± 66.9 ms, P = 0.003) and ECV was lower in myocarditis than in MI (34.5 ± 3.3 vs 53.8 ± 13.0 %, P = 0.004).Both inflammatory process and chronic fibrosis induce LGE (subepicardial in myocarditis and subendocardial in MI). The present study demonstrates that the determination of T1 and ECV is able to differentiate the 2 histological patterns.Further investigation will indicate whether the severity of ECV changes might help refine the predictive risk of LGE in myocarditis. 相似文献