Pathogenesis of infectious bronchitis nephritis. 2. Studies of water and electrolyte balance in colostomised chickens

Water and electrolyte balance was examined throughout the course of an experimental infection with T strain infectious bronchitis virus in colostomised chickens. Significant losses of water and negative sodium and potassium balances were observed. The major change in the electrolyte balance was the increased output of sodium in urine and this was associated with a diuresis. A decrease in food intake was the most important contribution to the negative potassium balance. Death resulted from acute renal failure. The implication of the results for electrolyte replacement therapy is discussed and a method for colostomies in birds weighing less than 0.5 kg is described.     

The influence of experimental distemper infection on the distribution of lead in dogs previously subacutely intoxicated with lead carbonate.

The ability of experimental canine distemper infection to mobilize body lead deposits has been studied in Beagle dogs previously subacutely intoxicated with lead carbonate. For comparative purposes dogs were included which had either received lead only or distemper only or remained undosed. It was found that in dogs predosed with lead, distemper infection resulted in a significant increase in lead levels in blood and urine; this coincided with the peak body temperatures reached on the third day post infection. It was also found that the lead content of the liver and bone of these dogs was considerably higher than that of dogs receiving lead alone; at the same time bone phosphorus showed a marked decrease while bone calcium values remained similar to undosed controls.