Diagnosis, classification and treatment of burns of the auricular conchae

On the basis of observation of 239 sufferers with burns of the ear auricles and analysis of clinical data, the authors have suggested a classification of such lesions. Primary lesions are associated with a direct influence of the thermal factor on the ear auricle tissues, and the secondary ones--with addition of infection. In treatment of the sufferers with burns of the ear auricles one should aim at prevention of the deepening of the burns and suppuration of a burn wound.     

Response, survival, and toxicity after iodine-131-metaiodobenzylguanidine therapy for neuroblastoma in preadolescents, adolescents, and adults

BACKGROUND:

Adolescent and adult patients with neuroblastoma appear to have a more indolent disease course but a lower survival rate compared with their younger counterparts. The majority of neuroblastoma tumors specifically accumulate the radiolabeled norepinephrine analogue iodine‐131–metaiodobenzylguanidine (¹³¹I‐MIBG). Therefore, ¹³¹I‐MIBG has become increasingly used as targeted radiotherapy for patients with recurrent or refractory neuroblastoma. The objective of the current study was to characterize the toxicity and activity of this therapy in older patients.

METHODS:

The authors performed a retrospective analysis of 39 consecutive patients aged ≥10 years with recurrent or refractory neuroblastoma who were treated with ¹³¹I‐MIBG monotherapy at the University of California at San Francisco under phase 1, phase 2, and compassionate access protocols.

RESULTS:

Sixteen patients were aged ≥18 years at the time of MIBG treatment initiation, whereas 23 patients were ages 10 to 17 years. The median cumulative administered dose of ¹³¹I‐MIBG was 17.8 millicuries (mCi)/kg. The majority of treatments led to grade 3 or 4 hematologic toxicities (graded according to the National Cancer Institute Common Terminology Criteria for Adverse Events [version 3]) that were similar in frequency among age strata. Three patients subsequently developed a hematologic malignancy or myelodysplasia. The overall rate of complete plus partial response was 46%. Patients aged ≥18 years at the time of first MIBG treatment had a significantly higher response rate compared with patients ages 10 to 17 years (56% vs 39%; P = .023). The median overall survival was 23 months with a trend toward longer overall survival for the subgroup of patients aged ≥18 years (P = .12).

CONCLUSIONS:

The findings of the current study suggest that ¹³¹I‐MIBG is a highly effective salvage agent for adolescents and adults with neuroblastoma. Cancer 2011;. © 2011 American Cancer Society.     

Osteosynthesis in patients with associated cranio-cerebral trauma]

In the article are presented the results of surgical treatment of 176 patients with associated craniocerebral injury. To the primary osteosynthesis in the first post-hospital day have been subjected 75 patients and to the postponed osteosynthesis--101 patient. For osteosynthesis there have been applied the methods of stable-functional osteosynthesis by plates (57.3%), by means of the external fixation apparatus (19.8%), by rods (10.8%) and by other means. The experience of the primary osteosynthesis, including the experience of simultaneous operation on 2-3 segments with application of the atraumatic technique, indicates that the operation doesn't aggravate the severity of injury but ensures more quick rehabilitation of the patients with craniocerebral injury, guarantees the complete restoration of function during 1-2 post-operative months.     

Synthesis and antiviral activity of derivatives of dibenzo-18-crown-6

Translated from Khimiko-farmatsevticheskii Zhurnal, Vol. 22, No. 7, pp. 836–839, July, 1988.