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91.
Reconciling scientific and religious discourse about madness during the age of reason: lessons for today? This paper argues that the secularization of madness, during the seventeenth and eighteenth centuries, occurred as a consequence of cultural change that accompanied the social upheavals of the age. In examining the reconciliation of competing explanations for madness, from theological and empirical viewpoints, it is suggested that these paradigms were never totally separated and argued that developments during this period were a consequence of continual interaction and dialogue between these contrasting views. Furthermore, it is suggested that an understanding of these changing times can illuminate present debates surrounding mental illness. 相似文献
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Alex Guttman MD Marc Afilalo MD Antoinette Colacone BSc Harvey Kreisman MD Jerrald Dankoff MD Asthma ED Study Group 《Academic emergency medicine》1997,4(2):100-106
Objective : To compare the efficacy of high-dose inhaled steroids in conjunction with IV steroids with that of IV steroids alone in the emergency treatment for acute asthma.
Methods : A double-blind, placebo-controlled, randomized trial was conducted on 60 ED patients presenting with acute asthma. All patients received nebulized salbutamol, and IV methylprednisolone, 80 mg at baseline and 40 mg at 6 hours. In addition to the above therapy, the experimental group received beclomethasone dipropionate (BDP) 7 mg over 8 hours via a metered-dose inhaler (MDI) attached to a holding chamber, while the control group received a placebo administered in the same fashion. Patients were treated on the protocol for 12 hours with the primary outcome measure being the change in % predicted FEV1 .
Results : Of 60 patients, 30 were randomized to BDP (age: 42 ± 16 years; FEV1 : 0.97 ± 0.42 L) and 30 were randomized to placebo (age: 37 ± 18 years; FEV1 : 0.98 ± 0.35 L). Spirometry and dyspnea measured by the Borg Scale improved significantly in both groups compared with baseline (p < 0.001). Changes in spirometry measures, dyspnea, and vital signs did not differ between treatment groups over the 12 hours of study (p > 0.05).
Conclusion : Inhaled BDP added to the standard regimen of IV methylprednisolone, and β-agonist did not further improve flow rates or dyspnea scores measured for up to 12 hours after presentation to the ED. 相似文献
Methods : A double-blind, placebo-controlled, randomized trial was conducted on 60 ED patients presenting with acute asthma. All patients received nebulized salbutamol, and IV methylprednisolone, 80 mg at baseline and 40 mg at 6 hours. In addition to the above therapy, the experimental group received beclomethasone dipropionate (BDP) 7 mg over 8 hours via a metered-dose inhaler (MDI) attached to a holding chamber, while the control group received a placebo administered in the same fashion. Patients were treated on the protocol for 12 hours with the primary outcome measure being the change in % predicted FEV
Results : Of 60 patients, 30 were randomized to BDP (age: 42 ± 16 years; FEV
Conclusion : Inhaled BDP added to the standard regimen of IV methylprednisolone, and β-agonist did not further improve flow rates or dyspnea scores measured for up to 12 hours after presentation to the ED. 相似文献
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A. R
ED 《Acta physiologica (Oxford, England)》1994,150(4):389-395
The membrane ‘labilizer’ veratridine (3.7 ± 10-6 m) which potentiates the contractions at twitch (0.1 Hz) stimulation due to multiple discharges, inhibited the tetanic contractions (50 Hz in 10 s) and the simultaneously recorded electromyogram in a use-dependent way, leading to fading of tetanic tension. The effect was equal during indirect and direct stimulation, and could therefore be localized to the excitable sarcolemma. This was confirmed by intracellular recording of action potentials, showing a marked veratridine-induced fallout of action potentials during continuous 50 Hz stimulation, whereas endplate potentials were unaffected. Accordingly, veratridine probably caused a use-dependent inhibition of the Na+ channels of the excitable sarcolemma. The tetanic fade was unaffected by K+ depolarization, increased by hyperpolarization in K+-free solution, and decreased by high Ca2+. All these changes of the ionic concentrations inhibited the twitch potentiating effect of veratridine. Since hyperpolarization and increasing the electric field in the membrane with high Ca,+ had opposite effects on the tetanic fade, the field change was probably not the cause of the antagonism in high Ca2+. Instead, a membrane stabilizing effect of high Ca2+ is suggested, since the neutral local anaesthetic benzocaine (1.5 ± 10-4 m), which is also a membrane stabilizing drug, had the same effects as high Ca2+ on the veratridine-induced tetanic fade. The effect of veratrine during tetanic stimulation was partly reversible upon washing. The reversibility was enhanced by high Ca2+ or benzocaine. 相似文献
95.
KS Tai J Brockwell FL Chan ED Janus KSL Lam 《Journal of Medical Imaging and Radiation Oncology》1995,39(1):61-65
Cerebrotendinous xanthomatosis is a rare familial sterol storage disease with accumulation of cholestanol and cholesterol particularly in xanthomas, bile and brain. Magnetic resonance imaging is a useful modality for imaging the affected tissues. It contributes to the evaluation and management of the disease. 相似文献
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The technical specifications and the operation of two atrial synchronous ventricular inhibited (ASVIP) pacemaker designs are described along with the results of clinical evaluation of these pacemakers in 30 patients. Clinical advantages of such pacemakers are contrasted with the performance of A-V sequential (DVI) and atrial synchronous (VAT) systems. 相似文献