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101.
Peritoneal interleukin-10 increases with decrease in activated CD4+ T lymphocytes in women with endometriosis 总被引:6,自引:5,他引:6
Ho HN; Wu MY; Chao KH; Chen CD; Chen SU; Yang YS 《Human reproduction (Oxford, England)》1997,12(11):2528-2533
This study was performed to determine whether peritoneal T cells are
suppressed in the CD4+ or CD8+ T cell subpopulation and whether they are
Th1 or Th2 predominant in women with endometriosis. Immune cells in the
peritoneal fluid (PF) were obtained from women undergoing laparoscopy for
endometriosis or tubal ligation. Three-colour flow cytometry was utilized
for immunophenotyping of peritoneal fluid mononuclear cells (PFMC).
Concentrations of interleukin (IL)-4, IL-5 and interferon-gamma (IFN-gamma)
produced by PFMC with and without mitogen stimulation and concentrations of
IL-10 and IL-12 were measured in PF. The peritoneal T lymphocytes were
predominantly of the Th1 type that produced much more IFN-gamma but less
IL-4 or IL-5 in women with or without endometriosis. The decrease in
peritoneal lymphocytes was significant in the HLA-DR+ CD4+ CD3+
subpopulation and the concentrations of peritoneal IL-10 and IL-12 were
significantly elevated in women with early stage endometriosis. There was
impaired IL- 5 production by PFMC after phytohaemagglutinin stimulation in
women with advanced stage endometriosis. We concluded that the activated
peritoneal CD4+ Th1 cells from the women with endometriosis were decreased
in number. The suppression of these T cells may be due to the elevation of
IL-10 and IL-12 in the peritoneal fluid.
相似文献
102.
Paired human chorionic gonadotrophin determinations for the prediction of pregnancy outcome in assisted reproduction 总被引:1,自引:0,他引:1
Chen CD; Ho HN; Wu MY; Chao KH; Chen SU; Yang YS 《Human reproduction (Oxford, England)》1997,12(11):2538-2541
The aim of this study was to determine the prognostic value of single and
paired measurements of serum concentrations of human chorionic
gonadotrophin (HCG) for successful pregnancy following in-vitro
fertilization (IVF) and tubal embryo transfer (TET). We analysed serum HCG
concentrations 15 and 22 days after IVF or TET in 198 conception cycles.
Cut-off values of serum HCG were determined by a receiver operating
characteristic (ROC) curve. On the basis of single HCG samples on day 15
(HCG15) after transfer, using a cut-off value of HCG15 = 150 mIU/ml, the
sensitivity was 71% and the specificity was 77%. The positive predictive
value (HCG15 > or = 150 mIU/ml indicating a normal pregnancy) was 89%,
while the negative predictive rate (HCG15 < 150 mIU/ml indicating an
abnormal pregnancy) was 51%. Patients with HCG15 < 150 mIU/ml but
HCG22/HCG15 ratio > or = 15, still had a 90% chance of normal pregnancy.
However, in patients with HCG15 < 150 mIU/ml and an HCG22/HCG15 ratio
< 15, there was an 84% chance of an abnormal pregnancy. We conclude that
a single HCG15 determination combined with the ratio of HCG22 to HCG15 has
a higher diagnostic accuracy for prediction of pregnancy outcome than
either analysis alone.
相似文献
103.
Total antioxidant status and nitric oxide do not increase in peritoneal fluids from women with endometriosis 总被引:7,自引:3,他引:7
Ho HN; Wu MY; Chen SU; Chao KH; Chen CD; Yang YS 《Human reproduction (Oxford, England)》1997,12(12):2810-2815
To explore the role of nitric oxide (NO) and oxidative stress in the
pathogenesis of adhesion formation and in endometriosis-associated
infertility, we examined the peritoneal total antioxidant status (TAS) and
the concentrations of products of NO metabolism in women with endometriosis
(early stage, n = 12; advanced stage, n = 12) and in fertile women without
endometriosis (n = 10). Peritoneal CA 125 and oestrogen and progesterone
concentrations were also measured to examine their contributions to TAS and
the production of NO. We failed to demonstrate any significant difference
in TAS and in the products of NO metabolism in peritoneal fluids among
women with early and advanced stages of endometriosis compared with fertile
women without endometriosis during the early follicular phase. TAS and the
concentration of the products of NO metabolism were not related to
concentrations of CA 125, oestrogen or progesterone. The concentration of
CA 125 in serum, but not in peritoneal fluid, was positively correlated
with the severity of endometriosis. The volume of peritoneal fluid and the
progesterone concentration were significantly increased in the group with
advanced endometriosis. TAS and the concentration of the products of NO
metabolism did not increase in peritoneal fluids from women with
endometriosis during the early follicular phase. Their role in the
pathophysiology of endometriosis needs to be explored further.
相似文献
104.
Normal human spermatozoa carry either the X or the Y chromosome. The
differences between X and Y spermatozoa (X and Y haploid cells) may exist
in two areas: the different chromosomes (i.e. different kinds and numbers
of genes) and the different sperm structures and functions (i.e. different
genetic expression). The aim of this study was to determine whether there
are any size between X and Y spermatozoa and whether sperm size and shape
varies between men. Identification of the Y (and X inferred) status of
individual spermatozoa was carried out by polymerase chain reaction (PCR),
amplifying the putative testis- determining gene (SRY) together with a
control gene (ZP3). PCR amplification of 871 out of 895 (97.3%) single
motile spermatozoa showed that 444 (51.0%) were Y and 427 (49.0%) were
X-bearing spermatozoa. Of 233 normally-shaped but immobilized spermatozoa,
217 (93.1%) were photographed and measured. Statistically, the length,
perimeter and area of the sperm heads, and the length of the sperm necks
and tails of X-bearing spermatozoa were significantly larger and longer
than those of Y-bearing spermatozoa. Some peculiarities (or variations) in
the X and Y sperm shape and size in individual donors were found. The
pre-screening by micro-measurement of these specific haploid
characteristics of individual spermatozoa in different donors, which may be
closely related to their different genetic conditions (or diseases), may be
important in human medicine and animal husbandry, especially in sperm
prefertilization diagnosis.
相似文献
105.
106.
107.
Background
About 1.4 million Salmonella infections, a common food-borne illness, occur in the U.S. annually; the elderly (aged 65 or above) are most susceptible. In 1997, the USDA introduced the Pathogen Reduction and Hazard Analysis and Critical Control Points Systems (PR/HACCP) which demands regular Salmonella testing in various establishments processing meat products, such as broiler chickens. Impact evaluations of PR/HACCP on hospitalizations related to Salmonella are lacking. 相似文献108.
CS Klade A Dohnal W Furst W Sommergruber KH Heider H Gharwan M Ratschek GR Adolf 《International journal of cancer. Journal international du cancer》2002,98(6):956-956
The original article to which this Erratum refers was published in International Journal of Cancer; 2002; 97(2) 217–224. 相似文献
109.
110.