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排序方式: 共有311条查询结果,搜索用时 15 毫秒
81.
Chiara Siri Roberto Cilia Danilo De Gaspari Federica Villa Stefano Goldwurm Catalano Marco Gianni Pezzoli Angelo Antonini 《Neurological sciences》2010,31(1):35-40
The frequency of psychopathological symptoms in patients with Parkinson’s disease (PD) is often underestimated because of
the lack of comprehensive evaluation tools. A total of 486 consecutive non-demented PD patients completed the Symptom Checklist
90 Revised (SCL-90R) self-reported questionnaire, a validated tool for the assessment of psychopathological symptoms on nine
dimensions. Somatization, depression, anxiety and obsessive–compulsive behaviors were reported by nearly half of the PD patients.
They were more likely to occur in females. Disease-related factors such as duration, severity and daily dosages, but not type
of dopaminergic medications, were associated with the occurrence of these symptoms. Psychopathological features are frequent
in PD and their occurrence is underlined by disease-related factors. 相似文献
82.
Wilk JB Tobin JE Suchowersky O Shill HA Klein C Wooten GF Lew MF Mark MH Guttman M Watts RL Singer C Growdon JH Latourelle JC Saint-Hilaire MH DeStefano AL Prakash R Williamson S Berg CJ Sun M Goldwurm S Pezzoli G Racette BA Perlmutter JS Parsian A Baker KB Giroux ML Litvan I Pramstaller PP Nicholson G Burn DJ Chinnery PF Vieregge P Slevin JT Cambi F MacDonald ME Gusella JF Myers RH Golbe LI 《Neurology》2006,67(12):2206-2210
83.
Rango M Canesi M Ghione I Farabola M Righini A Bresolin N Antonini A Pezzoli G 《Neurotoxicology》2006,27(2):164-168
Several patients with Parkinson' s disease (PD) reveal an history of chronic exposure to hydrocarbon-solvents. Chronic exposure to hydrocarbon-solvents has been proposed as a risk factor for more severe forms of PD with earlier onset of symptoms and reduced response to dopaminergic therapy. A direct correlation between disease severity and exposure degree has been previously shown. Seven exposed PD patients (two with low degree exposure and five with high degree exposure), 10 unexposed PD patients matched for sex, age and Hoehn and Yahr scale (=3 in the "on" phase), and 10 unexposed PD patients matched for sex, age and l-dopa daily intake instead of disease severity (Hoehn and Yahr scale=3.5 in the "on" phase) were studied. Twenty normal subjects without previous exposure to hydrocarbon-solvents and matched for age and sex with HPD patients were studied for comparison. The purpose of the study was to assess neuronal degeneration in the striatum of exposed vs unexposed PD patients. The authors investigated whether neuronal damage/loss was detectable in the lentiform nucleus measuring N-acetylaspartate (NAA) levels by 1-H MRS. Multiple single voxel MRS water-suppressed spectra were obtained also from the white matter and the occipital lobe. NAA was normal in the lentiform nucleus of patients with low exposure as well as in patients with no exposure whereas it was decreased in PD patients with high degree exposure. White matter and occipital lobe NAA content was normal both in exposed and unexposed PD patients. Clinical expression is more severe in PD patients with previous high degree solvent exposure because of the associated post-synaptic damage of the nigro-striatal pathway. 相似文献
84.
Zucca FA Bellei C Giannelli S Terreni MR Gallorini M Rizzio E Pezzoli G Albertini A Zecca L 《Journal of neural transmission (Vienna, Austria : 1996)》2006,113(6):757-767
Summary. In this study a comparative analysis of iron molecules during aging was performed in locus coeruleus (LC) and substantia nigra
(SN), known targets of Parkinson’s Disease (PD) and related disorders. LC and SN neurons, especially the SN pars compacta,
degenerate in PD and other forms of parkinsonism. Iron and its major molecular forms, such as ferritin and neuromelanin (NM),
were measured in LC and SN of normal subjects at various ages. Iron levels were lower, H-ferritin/iron ratio was higher and
the iron content in NM was lower in LC than in SN. Iron deposits were abundant in SN tissue, very scarse in LC tissue and
completely absent in pigmented neurons of both SN and LC. In both regions H- and L-ferritins were present only in glia. This
suggests that in LC neurons iron mobilization and toxicity is lower than that in SN and is efficiently buffered by NM. Ferritins
accomplish the same buffering function in glial cells. 相似文献
85.
Gianni Pezzoli Silvana Tesei Margherita Canesi Giorgio Sacilotto Montefusco Vittorio Yoshi Mizuno Hideki Mochizuki Angelo Antonini 《Clinical neurology and neurosurgery》2010
Granulocyte colony stimulating factor (GCSF) may boost physiological stem cell repair system in patients with cerebral lesions. Atypical parkinsonisms (PSP, CBD, MSA) are characterized by rapidly progressive course without significant benefit from current therapies. 相似文献
86.
Pezzoli N Silvy M Woronko A Le Treut T Lévy-Mozziconacci A Reviron D Gabert J Picard C 《Leukemia research》2007,31(9):1175-1183
This study has investigated quantification of chimerism in sex-mismatched transplantations by quantitative real time PCR (RQ-PCR) using FTA paper for blood sampling. First, we demonstrate that the quantification of DNA from EDTA-blood which has been deposit on FTA card is accurate and reproducible. Secondly, we show that fraction of recipient cells detected by RQ-PCR was concordant between the FTA and salting-out method, reference DNA extraction method. Furthermore, the sensitivity of detection of recipient cells is relatively similar with the two methods. Our results show that this innovative method can be used for MC assessment by RQ-PCR. 相似文献
87.
Tobin JE Latourelle JC Lew MF Klein C Suchowersky O Shill HA Golbe LI Mark MH Growdon JH Wooten GF Racette BA Perlmutter JS Watts R Guttman M Baker KB Goldwurm S Pezzoli G Singer C Saint-Hilaire MH Hendricks AE Williamson S Nagle MW Wilk JB Massood T Laramie JM DeStefano AL Litvan I Nicholson G Corbett A Isaacson S Burn DJ Chinnery PF Pramstaller PP Sherman S Al-hinti J Drasby E Nance M Moller AT Ostergaard K Roxburgh R Snow B Slevin JT Cambi F Gusella JF Myers RH 《Neurology》2008,71(1):28-34
88.
89.
Angelo Antonini Ioannis U Isaias Margherita Canesi Maurizio Zibetti Francesca Mancini Luigi Manfredi Marco Dal Fante Leonardo Lopiano Gianni Pezzoli 《Movement disorders》2007,22(8):1145-1149
We assessed prospectively clinical and quality of life changes in 9 patients with Parkinson's disease (PD; H&Y > or = 3) with severe motor fluctuations and dyskinesia who started continuous daily levodopa duodenal infusion through percutaneous endoscopic gastrostomy. Seven patients completed the follow-up period. Duration of "off" periods and time with disabling dyskinesia shortened significantly in all patients (P < 0.01). Total daily dose of levodopa infused did not differ from baseline equivalents. There were significant improvements in UPDRS-II (activities of daily living) and -IV (motor complications) in the "on" condition (P < 0.02), and in four PDQ-39 domains (mobility, activities of daily living, stigma, bodily discomfort; P < 0.05). Two patients withdrew for adverse events. Our results demonstrate that a satisfactory therapeutic window can be achieved and maintained for several months in advanced PD patients. 相似文献