全文获取类型
收费全文 | 206659篇 |
免费 | 1960篇 |
国内免费 | 214篇 |
专业分类
耳鼻咽喉 | 1362篇 |
儿科学 | 7257篇 |
妇产科学 | 3716篇 |
基础医学 | 20969篇 |
口腔科学 | 2249篇 |
临床医学 | 14681篇 |
内科学 | 37404篇 |
皮肤病学 | 1182篇 |
神经病学 | 19055篇 |
特种医学 | 9931篇 |
外科学 | 33106篇 |
综合类 | 4193篇 |
一般理论 | 32篇 |
预防医学 | 20157篇 |
眼科学 | 3066篇 |
药学 | 11700篇 |
28篇 | |
中国医学 | 746篇 |
肿瘤学 | 17999篇 |
出版年
2023年 | 262篇 |
2022年 | 703篇 |
2021年 | 1438篇 |
2020年 | 837篇 |
2019年 | 1294篇 |
2018年 | 23469篇 |
2017年 | 18235篇 |
2016年 | 20720篇 |
2015年 | 2624篇 |
2014年 | 2895篇 |
2013年 | 3446篇 |
2012年 | 9493篇 |
2011年 | 22687篇 |
2010年 | 20486篇 |
2009年 | 12883篇 |
2008年 | 20860篇 |
2007年 | 22888篇 |
2006年 | 1898篇 |
2005年 | 3436篇 |
2004年 | 4398篇 |
2003年 | 4980篇 |
2002年 | 3086篇 |
2001年 | 415篇 |
2000年 | 633篇 |
1999年 | 400篇 |
1998年 | 456篇 |
1997年 | 393篇 |
1996年 | 257篇 |
1995年 | 211篇 |
1994年 | 195篇 |
1993年 | 163篇 |
1992年 | 125篇 |
1991年 | 164篇 |
1990年 | 204篇 |
1989年 | 155篇 |
1988年 | 130篇 |
1987年 | 100篇 |
1986年 | 89篇 |
1985年 | 84篇 |
1984年 | 80篇 |
1983年 | 59篇 |
1982年 | 83篇 |
1980年 | 88篇 |
1970年 | 39篇 |
1968年 | 42篇 |
1938年 | 77篇 |
1937年 | 42篇 |
1934年 | 43篇 |
1932年 | 65篇 |
1930年 | 68篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
11.
Hui-Ju Ch’ang 《World journal of hepatology》2015,7(16):2029-2040
The success of sorafenib in prolonging survival of patients with hepatocellular carcinoma (HCC) makes therapeutic inhibition of angiogenesis a component of treatment for HCC. To enhance therapeutic efficacy, overcome drug resistance and reduce toxicity, combination of antiangiogenic agents with chemotherapy, radiotherapy or other targeted agents were evaluated. Nevertheless, the use of antiangiogenic therapy remains suboptimal regarding dosage, schedule and duration of therapy. The issue is further complicated by combination antiangiogenesis to other cytotoxic or biologic agents. There is no way to determine which patients are most likely respond to a given form of antiangiogenic therapy. Activation of alternative pathways associated with disease progression in patients undergoing antiangiogenic therapy has also been recognized. There is increasing importance in identifying, validating and standardizing potential response biomarkers for antiangiogenesis therapy for HCC patients. In this review, biomarkers for antiangiogenesis therapy including systemic, circulating, tissue and imaging ones are summarized. The strength and deficit of circulating and imaging biomarkers were further demonstrated by a series of studies in HCC patients receiving radiotherapy with or without thalidomide. 相似文献
12.
13.
N. S. Hari Narayana Moorthy Sergio F. Sousa Maria J. Ramos Pedro A. Fernandes 《Medicinal chemistry research》2016,25(7):1340-1357
Farnesyltransferase (FTase) is one of the prenyltransferase family enzymes that catalyse the transfer of 15-membered isoprenoid (farnesyl) moiety to the cysteine of CAAX motif-containing proteins including Rho and Ras family of G proteins. Inhibitors of FTase act as drugs for cancer, malaria, progeria and other diseases. In the present investigation, we have developed two structure-based pharmacophore models from protein–ligand complex (3E33 and 3E37) obtained from the protein data bank. Molecular dynamics (MD) simulations were performed on the complexes, and different conformers of the same complex were generated. These conformers were undergone protein–ligand interaction fingerprint (PLIF) analysis, and the fingerprint bits have been used for structure-based pharmacophore model development. The PLIF results showed that Lys164, Tyr166, TrpB106 and TyrB361 are the major interacting residues in both the complexes. The RMSD and RMSF analyses on the MD-simulated systems showed that the absence of FPP in the complex 3E37 has significant effect in the conformational changes of the ligands. During this conformational change, some interactions between the protein and the ligands are lost, but regained after some simulations (after 2 ns). The structure-based pharmacophore models showed that the hydrophobic and acceptor contours are predominantly present in the models. The pharmacophore models were validated using reference compounds, which significantly identified as HITs with smaller RMSD values. The developed structure-based pharmacophore models are significant, and the methodology used in this study is novel from the existing methods (the original X-ray crystallographic coordination of the ligands is used for the model building). In our study, along with the original coordination of the ligand, different conformers of the same complex (protein–ligand) are used. It concluded that the developed methodology is significant for the virtual screening of novel molecules on different targets. 相似文献
14.
Valerie Iles 《Health care analysis》2016,24(2):105-118
This paper takes a somewhat slant perspective on flourishing and care in the context of suffering, death and dying, arguing that care in this context consists principally of ‘acts of work and courage that enable flourishing’. Starting with the perception that individuals, society and health care professionals have become dulled to death and the process of dying in Western advanced health systems, it suggests that for flourishing to occur, both of these aspects of life need to be faced more directly. The last days of life need to be ‘undulled’. Reflections upon the experiences of the author as carer and daughter in the face of her mother’s experience of death are used as basis for making suggestions about how care systems and professionals might better assist people in dealing with ‘the most grown up thing’ humans ever do, which is to die. 相似文献
15.
16.
17.
18.
Maria Gonzalez-Cao Cristina Carrera Juan Francisco Rodriguez Moreno Pedro Rodríguez-Jiménez Mónica Antoñanzas Basa Rosa Feltes Ochoa Teresa Puertolas Eva Muñoz-Couselo José Luis Manzano Ivan Marquez-Rodas Juan Martín-Liberal Ainara Soria Pilar Lopez Criado Almudena Garcia-Castaño Aram Boada Pablo Ayala de Miguel Susana Puig Guillermo Crespo Alfonso Berrocal 《Journal of the American Academy of Dermatology》2021,84(5):1412-1415
19.