腹腔镜宫颈肌瘤挖除术与开腹宫颈肌瘤挖除术的对比分析

目的：探讨腹腔镜宫颈肌瘤挖除手术的方法和临床价值。方法：回顾分析2004年9月-2010年1月28例在上海交通大学医学院附属瑞金医院妇科行腹腔镜下宫颈肌瘤挖除术（腹腔镜组）患者的临床资料,随机选取同年30例开腹行同类手术患者（开腹组）作为对照。结果：腹腔镜组术中出血量（68．21±42．60mL）显著少于开腹组（152．33±66．22mL）（P〈0．05）;腹腔镜组术后肛门排气时间（24．96±3．81d）,显著短于开腹组的（28．73±6．23d）（P〈0．05）;腹腔镜组术后留置导尿平均时间（27．89±7．22h）,显著短于开腹组（31．93±7．75h）（P〈0．05）;腹腔镜组术后住院平均时间（6．33±1．01d）,显著短于开腹组（7．65±0．77d）（P〈0．05）。2组肌瘤大小和手术时间比较差异均无统计学意义（P〉0．05）。结论：腹腔镜宫颈肌瘤挖除术是安全、有效的手术方法,掌握其手术适应证和良好的手术技巧是成功的关键。     

Use of early corticosteroid therapy on ICU admission in patients affected by severe pandemic (H1N1)v influenza?A infection

Introduction

Early use of corticosteroids in patients affected by pandemic (H1N1)v influenza?A infection, although relatively common, remains controversial.

Methods

Prospective, observational, multicenter study from 23 June 2009 through 11 February 2010, reported in the European Society of Intensive Care Medicine (ESICM) H1N1 registry.

Results

Two hundred twenty patients admitted to an intensive care unit (ICU) with completed outcome data were analyzed. Invasive mechanical ventilation was used in 155 (70.5%). Sixty-seven (30.5%) of the patients died in ICU and 75 (34.1%) whilst in hospital. One hundred twenty-six (57.3%) patients received corticosteroid therapy on admission to ICU. Patients who received corticosteroids were significantly older and were more likely to have coexisting asthma, chronic obstructive pulmonary disease (COPD), and chronic steroid use. These patients receiving corticosteroids had increased likelihood of developing hospital-acquired pneumonia (HAP) [26.2% versus 13.8%, p?p?p?=?0.4] but was still associated with an increased rate of HAP (OR 2.2, 95% CI 1.0?C4.8, p?Conclusions Early use of corticosteroids in patients affected by pandemic (H1N1)v influenza?A infection did not result in better outcomes and was associated with increased risk of superinfections.