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971.
Rajesh Thippeshappa Baoping Tian Brad Cleveland Wenjin Guo Patricia Polacino Shiu-Lok Hu 《Clinical and Vaccine Immunology : CVI》2016,23(3):204-212
Human immunodeficiency virus type 1 (HIV-1) acquisition occurs predominantly through mucosal transmission. We hypothesized that greater mucosal immune responses and protective efficacy against mucosal HIV-1 infection may be achieved by prime-boost immunization at mucosal sites. We used a macaque model to determine the safety, immunogenicity, and protective efficacy of orally delivered, replication-competent but attenuated recombinant vaccinia viruses expressing full-length HIV-1 SF162 envelope (Env) or simian immunodeficiency virus (SIV) Gag-Pol proteins. We examined the dose and route that are suitable for oral immunization with recombinant vaccinia viruses. We showed that sublingual inoculation of two vaccinia virus-naive pigtailed macaques with 5 × 108 PFU of recombinant vaccinia viruses was safe. However, sublingual inoculation with a higher dose or tonsillar inoculation resulted in secondary oral lesions, indicating the need to optimize the dose and route for oral immunization with replication-competent vaccinia virus vectors. Oral priming alone elicited antibody responses to vaccinia virus and to the SF162 Env protein. Intramuscular immunization with the SF162 gp120 protein at either 20 or 21 weeks postpriming resulted in a significant boost in antibody responses in both systemic and mucosal compartments. Furthermore, we showed that immune responses induced by recombinant vaccinia virus priming and intramuscular protein boosting provided protection against intrarectal challenge with the simian-human immunodeficiency virus SHIV-SF162-P4. 相似文献
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Influence of hydroxyapatite granule size,porosity, and crystallinity on tissue reaction in vivo. Part A: synthesis,characterization of the materials,and SEM analysis
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Maria José Magalhães Patricia Alonso Ruido Rita DeOliveira Braga Lopez 《Health care for women international》2016,37(12):1304-1319
In this article, we explore professionals' representations of elderly female victims of gender violence. Semi-structured interviews were used to explore seven professionals' work philosophies and intervention methodologies in their work with elderly female victims of violence, their main problems and difficulties, and their perspectives regarding shelters for elderly women. Results show that there are no specific philosophies and methodologies to intervene with these victims. There is a tendency to homogenize all the victims of gender violence, regardless of their age and specific needs. The professionals also tended to trivialize gender violence against elderly female victims, considering that these women tolerate violence. 相似文献
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Experience dependent plasticity refers to ability of the brain to adapt to new experiences by changing its structure and function. The purpose of this paper is to provide a brief review the neurophysiological and structural correlates of neural plasticity that occur during and following motor learning. We also consider that the extent of plastic reorganization is dependent upon several key principals and that the resulting behavioral consequences can be adaptive or maladaptive. In light of this research, we conclude that an increased understanding of the complexities of brain plasticity will translate into enhanced treatment opportunities for the clinician to optimize hand function. 相似文献