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排序方式: 共有2727条查询结果,搜索用时 15 毫秒
71.
Carlos de Paula Eduardo Ana Cecilia Corrêa Aranha Alyne Simões Marina Stella Bello-Silva Karen Muller Ramalho Marcella Esteves-Oliveira Patrícia Moreira de Freitas Juliana Marotti Jan Tunér 《Lasers in medical science》2014,29(4):1517-1529
Recurrent herpes labialis is a worldwide life-long oral health problem that remains unsolved. It affects approximately one third of the world population and causes frequent pain and discomfort episodes, as well as social restriction due to its compromise of esthetic features. In addition, the available antiviral drugs have not been successful in completely eliminating the virus and its recurrence. Currently, different kinds of laser treatment and different protocols have been proposed for the management of recurrent herpes labialis. Therefore, the aim of the present article was to review the literature regarding the effects of laser irradiation on recurrent herpes labialis and to identify the indications and most successful clinical protocols. The literature was searched with the aim of identifying the effects on healing time, pain relief, duration of viral shedding, viral inactivation, and interval of recurrence. According to the literature, none of the laser treatment modalities is able to completely eliminate the virus and its recurrence. However, laser phototherapy appears to strongly decrease pain and the interval of recurrences without causing any side effects. Photodynamic therapy can be helpful in reducing viral titer in the vesicle phase, and high-power lasers may be useful to drain vesicles. The main advantages of the laser treatment appear to be the absence of side effects and drug interactions, which are especially helpful for older and immunocompromised patients. Although these results indicate a potential beneficial use for lasers in the management of recurrent herpes labialis, they are based on limited published clinical trials and case reports. The literature still lacks double-blind controlled clinical trials verifying these effects and such trials should be the focus of future research. 相似文献
72.
Platelet a disintegrin and metallopeptidase 10 expression correlates with clock drawing test scores in Alzheimer's disease
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73.
Increased frequency of cluster of differentiation 14 (CD14+) monocytes expressing interleukin 1 beta (IL‐1β) in Alzheimer's disease patients and intermediate levels in late‐onset depression patients
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74.
Carla Silva-Batista Hélcio Kanegusuku Hamilton Roschel Eduardo O. Souza Telma F. Cunha Gilberto C. Laurentino N. Manoel Jr Marco T. De Mello Maria E.P. Piemonte Patrícia C. Brum Claudia L. Forjaz Valmor Tricoli Carlos Ugrinowitsch 《Journal of Sports Science and Medicine》2014,13(3):597-603
This case report assessed quality of life, activities of daily living, motor symptoms, functional ability, neuromuscular parameters and mRNA expression of selected genes related to muscle protein synthesis and degradation in a patient with Multiple System Atrophy (MSA). The patient underwent resistance training with instability devices (i.e., bosu, dyna disk, balance disk, Swiss ball) for six months twice a week. After the six months training, the patient’s left and right quadriceps muscle cross-sectional area and leg press one-repetition maximum increased 6.4%, 6.8%, and 40%, respectively; the patient’s timed up and go, sit to stand, dynamic balance, and activities of daily living improved 33.3%, 28.6%, 42.3%, and 40.1%, respectively; the patient’s severity of motor symptoms and risk of falls decreased 32% and 128.1%, respectively. Most of the subscales of quality of life demonstrated improvements as well, varying from 13.0% to 100.0%. mRNA expression of mechanogrowth factor and mammalian target of rapamycin increased 12.7-fold and 1.5-fold, respectively. This case report describes likely the first nonpharmacological therapeutic tool that might be able to decrease the severity of motor symptoms and risk of falls, and to improve functional ability, neuromuscular parameters, and quality of the life in a patient with MSA.
Key points
- Six months of resistance training with instability alleviate the MSA-related effects and improve the quality of life in a patient with MSA.
- High complexity exercise intervention (i.e., resistance training with instability) may be very beneficial to individuals with impaired motor control and function as MSA patients.
- Caution should be exercised when interpreting our findings as they cannot be generalized to the entire MSA population and they do not allow establishing causal conclusions on the effects of this mode of exercise on MSA.
75.
José-Francisco Rocha Amílcar Falcão Ana Santos Roberto Pinto Nelson Lopes Teresa Nunes Lyndon C. Wright Manuel Vaz-da-Silva Patrício Soares-da-Silva 《European journal of clinical pharmacology》2014,70(9):1059-1071
Background and objectives
Opicapone is a novel third generation catechol-O-methyltransferase (COMT) inhibitor. The purpose of this study was to compare the levodopa pharmacokinetic profile throughout a day driven by the COMT inhibition either following repeated doses of opicapone or concomitant administration with entacapone.Methods
A randomized, double-blind, gender-balanced, parallel-group study was performed in 4 groups of 20 healthy subjects each. Four subjects in each group received placebo during the entire study. Sixteen subjects in one group received placebo once daily for 11 days and on day 12, 200 mg entacapone concomitantly with each levodopa/carbidopa dose (three times separated by a 5-h interval). Sixteen subjects in each of the remaining three groups received respectively 25, 50, and 75 mg opicapone once daily for 11 days and on day 12, placebo concomitantly with each levodopa/carbidopa dose.Results
Levodopa minimum plasma concentration (Cmin) for each levodopa/carbidopa dose and for the mean of all levodopa/carbidopa doses increased substantially with all active treatments (entacapone and opicapone) when compared to the control group (placebo), with values ranging from 1.7-fold (200 mg entacapone) to 3.3-fold (75 mg opicapone). No statistical difference was found for levodopa peak of systemic exposure (as assessed by maximum observed plasma concentration (Cmax)) between all active treatments and placebo. A significant increase in the levodopa extent of systemic exposure (as assessed by concentration-time curve (AUC)) occurred with all opicapone treatments in relation to placebo. No statistical difference was found for levodopa AUC when entacapone was compared to placebo. When compared to entacapone, both 50 and 75 mg opicapone presented a significant increase for the levodopa AUC. All active treatments significantly inhibited both peak (as assessed by Emax) and extent (as assessed by effect-time curve (AUEC)) of the COMT activity in relation to placebo. When compared to entacapone, all opicapone treatments significantly decreased the extent (AUEC) of the COMT activity due to a long-lasting and sustained effect. The tolerability profile was favorable for all active treatments.Conclusion
Opicapone, a novel third generation COMT inhibitor, when compared to entacapone, provides a superior response upon the bioavailability of levodopa associated to more pronounced, long-lasting, and sustained COMT inhibition. The tolerability profile was favorable. On the basis of the results presented in this study and along with the earlier pharmacology studies, it is anticipated that opicapone adjunct therapy at the dosages of 25 and 50 mg will provide an enhancement in levodopa availability that will translate into clinical benefit for Parkinson’s disease patients. 相似文献76.
Alexandre Abizaid MD PhD Carlos M. Campos MD PhD Patrícia O. Guimarães MD PhD José de Ribamar Costa Jr. PhD MD Breno A. A. Falcão MD PhD Fernanda Mangione MD Adriano Caixeta MD PhD Pedro A. Lemos MD PhD Fabio S. de Brito Jr. MD PhD Ricardo Cavalcante MD Cristiano Guedes Bezerra MD PhD Leandro Cortes MD Henrique B. Ribeiro MD PhD Francis R. de Souza PhD Natassja Huemer BS Renata M. do Val BS Bruno Caramelli MD PhD Daniela Calderaro MD PhD Felipe G. Lima MD Ludhmila A. Hajjar MD PhD Roxana Mehran MD Roberto Kalil Filho MD PhD the COVID MI investigators 《Catheterization and cardiovascular interventions》2021,98(3):E370-E378
77.
Vanderborght PR Matos HJ Salles AM Vasconcellos SE Silva-Filho VF Huizinga TW Ottenhoff TH Sampaio EP Sarno EN Santos AR Moraes MO 《International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association》2004,72(2):143-148
Tumor necrosis factor alpha (TNFalpha) plays a key role in orchestrating the complex events involved in inflammation and immune response. The presence of single nucleotide polymorphisms (SNPs) within the promoter region of the TNFa gene has been associated with a number of diseases. The aim of this study was to investigate the distribution of polymorphisms at positions -238 (G/A) and -308 (G/A) at the TNFalpha promoter, and its association to the outcome of different clinical forms of leprosy. Furthermore, the bacteriological index (BI) was evaluated among genotyped multibacillary (MB) patients in order to investigate the possible influence of each polymorphism on the bacterial load. This study included a total of 631 leprosy patients being 401 MB and 230 paucibacillary (PB), that was further separated according to its ethnicity (Afro- and Euro-Brazilians). The combination of SNPs in haplotypes generated three different arrangements: TNFG-G, TNFG-A and TNFA-G. In spite of the marked differences observed in the frequency of the haplotypes along the ethnic groups, no statistical differences were observed in haplotype frequencies between MB and PB patients. The BI analyses showed a lower bacteriological index among the -308 carriers, while the BI of the -238 carriers was higher. Although no significance has been achieved in this analysis regarding the influence of the polymorphisms to the development of the clinical outcome, it seems that in a different stage (among the MB patients) the polymorphisms could contribute to the degree of severity observed. 相似文献
78.
Cristiane Maria Pinto Diniz Tiago Lopes Farias Mayane Carneiro Alves Pereira Caio Breno Reis Pires Luciana Soares Lages Gonçalves Patrícia Chaves Coertjens Marcelo Coertjens 《International journal of occupational medicine and environmental health》2014,27(2):216-223
Objectives
The aim of this study was to verify and analyze the existence of chronic adaptations of lung function in free-diving fishermen whose occupation is artisanal fishing.Material and Methods
This was a cross-sectional study involving 11 breath-hold diving fishermen and 10 non-breath-hold diving fishermen (control) from the village of Bitupitá in the municipality of Barroquinha (Ceará — Brazil). Anthropometric measurements, chest and abdominal circumferences as well as spirometric and respiratory muscle strength tests were conducted according to the specifications of the American Thoracic Society/European Respiratory Society (ATS/ERS). In order to compare the measured values versus the predicted values, Student t test was used in the case of parametric test and Wilcoxon test in the case of nonparametric test. To compare the inter-group means Student t test was used for parametric test and Mann-Whitney test for the nonparametric one. The level of significance was set at α = 5%.Results
The forced vital capacity (FVC) (4.9±0.6 l vs. 4.3±0.4 l) and forced expiratory volume in 1 s (FEV1) (4.0±0.5 l vs. 3.6±0.3 l) were, respectively, higher in the group of divers compared to the control group (p ≤ 0.05). Furthermore, in the group of free divers, the measured FVC, FEV1 and FEV1/FVC ratios were significantly greater than the predicted ones. No differences were found between the measured respiratory pressures.Conclusions
These results indicate that breath-hold diving seems to produce chronic adaptations of the respiratory system, resulting in elevated lung volumes with no airway obstruction. 相似文献79.
80.
Quintana Ramiro Martins Jardine Alexander Pompermayer Grechi Tuane Regina Grazziotin-Soares Renata Ardenghi Diego Machado Scarparo Roberta Kochenborger Grecca Fabiana Soares Kopper Patrícia Maria Poli 《Clinical oral investigations》2019,23(3):1359-1366
Clinical Oral Investigations - This study aims to compare the bone tissue reaction, setting time, solubility, and pH of NeoMTA Plus, Biodentine (BD), and MTA Angelus (MTA-A). Initial and final... 相似文献