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41.
In the last decade community and hospital-based studies of epilepsy from the onset of the disorder have revealed a much more favorable prognosis for seizure control than previously reported. Approximately three-quarters of newly diagnosed patients can enter a prolonged remission on currently available medication. The natural history of untreated epilepsy is unknown but there is some evidence of an escalating process in the early stages in patients with tonic-clonic seizures. The first two years of treatment seem to be important in determining the subsequent course of epilepsy. The longer seizures continue, the less likely they are to b: controlled. Early effective treatment may be important in preventing the evolution of chronic epilepsy. These observations have implications for the management of patients with single seizures. 相似文献
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Dr Lynne Jones OBE MRCPsych Joseph B Asare GM FRCPsych Mustafa El Masri MD Andrew Mohanraj MBBS Hassen Sherief MD Mark van Ommeren PhD 《Lancet》2009,374(9690):654-661
People with severe mental disorders are a neglected and vulnerable group in complex emergencies. Here, we describe field experiences in establishing mental health services in five humanitarian settings. We show data to quantify the issue, and suggest reasons for this neglect. We then outline the actions needed to establish services in these settings, including the provision of practical training, medication, psychosocial supports, and, when appropriate, work with traditional healers. We have identified some persisting problems locally, nationally, and internationally, and suggest some solutions. Protection and care of people with severe mental disorders in complex emergencies is a humanitarian responsibility. 相似文献
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David M. Ndetei MBChB DPM MRCPsych FRCPsych MD Lincoln I. Khasakhala MBChB MSc Clinical Psychology Victoria Mutiso MSc Clinical Psychology Francisca A. Ongecha-Owuor MBChB MMed Psych Donald A. Kokonya MBChB MMed Psych 《Substance Abuse》2013,34(3):170-173
ABSTRACT Alcohol abuse and alcohol-related use problems among adolescents are highly prevalent and are a major concern worldwide. This study estimated the prevalence of drug abuse, knowledge about drug abuse and its effect on psychosocial well-being and induced behavioral problems among students of a public rural secondary school that admitted both girls and boys which offered both boarding and day school facilities. The students filled out a self-reporting substance use tool which measures the prevalence, frequency, and general patterns of substance use. Alcohol, tobacco, khat (catha edulis) and bhang (cannabis) were the most commonly reported substance of use, with user prevalence rates of 5.2%, 3.8%, 3.2%, and 1.7%, respectively. Tobacco use was initiated at 10 years, while cannabis, hard drugs, khat, and alcohol were initiated at 11, 12, 13, and 15 years of age, respectively. Among the students 71% were aware that their schoolmates were on drugs and it was known by 49.8%, 41.7%, 37.6%, 44.3%, and 32.4% of these students that using alcohol, tobacco, khat, cannabis, and hard drugs, respectively was a behavioral problem in the school. Three quarters of the students were aware that use of drugs was harmful to their health, with majority (78.6%) indicating that drug users need help to stop the drug use behavior. However most (73.6%) of the students suggested drug users in school should be punished. The drug use behavioral problems included school dropout, poor scholastic attainment, drunken driving, delinquency, and adolescence pregnancy which threaten the stability of the education system, family as an institution (family difficulties) and society at large. Therefore, teachers have an added burden of playing an active role in guidance and counselling the survivors of drug abuse, a pandemic facing teaching institutions apart from instilling knowledge. 相似文献
47.
Bhavitavya Nijampatnam Parmanand Ahirwar Piyasuda Pukkanasut Holly Womack Luke Casals Hua Zhang Xia Cai Suzanne M. Michalek Hui Wu Sadanandan E. Velu 《ACS medicinal chemistry letters》2021,12(1):48
Dental caries is a bacterial infectious disease characterized by demineralization of the tooth enamel. Treatment of this disease with conventional antibiotics is largely ineffective as the cariogenic bacteria form tenacious biofilms that are resistant to such treatments. The main etiological agent for dental caries is the bacterium Streptococcus mutans. S. mutans readily forms biofilms on the tooth surface and rapidly produces lactic acid from dietary sucrose. Glucosyl transferases (Gtfs) secreted by S. mutans are mainly responsible for the production of exopolysaccharides that are crucial for the biofilm architecture. Thus, inhibiting S. mutans’ Gtfs is an effective approach to develop selective biofilm inhibitors that do not affect the growth of oral commensals. Herein, we report a library of 90 analogs of the previously identified lead compound, G43, and exploration of its structure activity relationships (SAR). All compounds were evaluated for the inhibition of S. mutans biofilms and bacterial growth. Selected compounds from this library were further evaluated for enzyme inhibition against Gtfs using a zymogram assay and for growth inhibition against oral commensal bacterial species such as Streptococcus gordonii and Streptococcus sanguinis. This study has led to the discovery of several new biofilm inhibitors with enhanced potency and selectivity. One of the leads, IIIF1, showed marked reduction in buccal, sulcal, and proximal caries scores in a rat model of dental caries. 相似文献
48.
Written case formulations in the treatment of anorexia nervosa: Evidence for therapeutic benefits 下载免费PDF全文
Karina L. Allen BA MPsych PhD Caitlin B. O'Hara PhD Savani Bartholdy MSc Beth Renwick BSc Alexandra Keyes BSc MSc Anna Lose BSc MSc Martha Kenyon MSc Hannah DeJong BA DClinPsy Hannah Broadbent MSc DClinPsy Rachel Loomes BA MSc Jessica McClelland BSc PhD Lucy Serpell BA DClinPsy PhD Lorna Richards MBChB MA Eric Johnson‐Sabine MBBS MRCGP FRCPsych Nicky Boughton MSc Linette Whitehead MSc Janet Treasure MD PhD FRCP FRCPsych OBE Tracey Wade BSc MPsych PhD Ulrike Schmidt MD PhD FRCPsych 《The International journal of eating disorders》2016,49(9):874-882
49.
Two‐year follow‐up of the MOSAIC trial: A multicenter randomized controlled trial comparing two psychological treatments in adult outpatients with broadly defined anorexia nervosa 下载免费PDF全文
Ulrike Schmidt MD PhD FRCPsych Elizabeth G. Ryan PhD Savani Bartholdy MSc Bethany Renwick Bsc Alexandra Keyes MSc Caitlin O'Hara PhD Jessica McClelland PhD Anna Lose MSc Martha Kenyon MSc Hannah Dejong ClinPsyD Hannah Broadbent PhD Rachel Loomes MSc Lucy Serpell PhD DClinPsy Lorna Richards MD Eric Johnson‐Sabine MD Nicky Boughton MSc Linette Whitehead MSc Eva Bonin MA Jennifer Beecham PhD Sabine Landau PhD Janet Treasure OBE MD PhD FRCP FRCPsych 《The International journal of eating disorders》2016,49(8):793-800
50.
BACKGROUND: Discrepancy between efficacy of prophylactic lithium and its effectiveness in ordinary clinical practice necessitates long-term follow-up data from specialised lithium clinics. Also, role of psychosocial factors in influencing the outcome is unclear. METHODS: One hundred and eighteen patients of bipolar affective disorder attending a lithium clinic were followed-up for approximately 11 years (range 2-27 years). Demographic and clinical data, measures of social support and psychosocial stress were obtained at the intake in 1989-1990. Study design combined retrospective chart-review (till the time of intake) with prospective follow-up till July 1995. RESULTS: On lithium, the patients had a mean of 0.43 relapses per year (manic, 0.26; depressive, 0.17) which was significantly less (p < 0.01) than the pre-lithium episode frequency. The figure for entirely relapse-free patients was 24%, and 62% had relapses up to one episode per year (median = 0.3 per year). Fifty-eight (49%) patients were good responders to lithium (relapses < or = 0.30 per year). In comparison to good responders, partial/poor responders had a significantly greater number of pre-lithium depressive episodes, poor lithium compliance, more psychosocial stress and lower social support at intake. These variables correlated well with relapses and explained 32% of the variance of the data. CONCLUSIONS: Lithium had a definite prophylactic effect on long-term outcome. Social support and stressful life events are significant correlates of response to lithium. CLINICAL IMPLICATIONS: Lithium prophylaxis of bipolar affective disorders seems justified though psychosocial factors appear to modulate its effectiveness. LIMITATIONS: Other psychotropic medications were used during relapse and the assessment of psychosocial factors was cross-sectional. 相似文献