全文获取类型
收费全文 | 3774796篇 |
免费 | 300972篇 |
国内免费 | 14661篇 |
专业分类
耳鼻咽喉 | 50672篇 |
儿科学 | 119282篇 |
妇产科学 | 97598篇 |
基础医学 | 590224篇 |
口腔科学 | 102165篇 |
临床医学 | 339766篇 |
内科学 | 672760篇 |
皮肤病学 | 98424篇 |
神经病学 | 316584篇 |
特种医学 | 146820篇 |
外国民族医学 | 262篇 |
外科学 | 580551篇 |
综合类 | 113859篇 |
现状与发展 | 23篇 |
一般理论 | 2356篇 |
预防医学 | 310542篇 |
眼科学 | 88900篇 |
药学 | 260664篇 |
26篇 | |
中国医学 | 11408篇 |
肿瘤学 | 187543篇 |
出版年
2021年 | 55566篇 |
2020年 | 35377篇 |
2019年 | 58471篇 |
2018年 | 72711篇 |
2017年 | 55490篇 |
2016年 | 61346篇 |
2015年 | 75100篇 |
2014年 | 109315篇 |
2013年 | 174720篇 |
2012年 | 104280篇 |
2011年 | 106123篇 |
2010年 | 120674篇 |
2009年 | 123622篇 |
2008年 | 92706篇 |
2007年 | 97275篇 |
2006年 | 106757篇 |
2005年 | 101530篇 |
2004年 | 103246篇 |
2003年 | 93189篇 |
2002年 | 82537篇 |
2001年 | 136047篇 |
2000年 | 129599篇 |
1999年 | 121971篇 |
1998年 | 68576篇 |
1997年 | 65256篇 |
1996年 | 62985篇 |
1995年 | 58534篇 |
1994年 | 52522篇 |
1993年 | 48887篇 |
1992年 | 85020篇 |
1991年 | 80941篇 |
1990年 | 76651篇 |
1989年 | 75091篇 |
1988年 | 69004篇 |
1987年 | 67190篇 |
1986年 | 63524篇 |
1985年 | 62751篇 |
1984年 | 54862篇 |
1983年 | 49568篇 |
1982年 | 43614篇 |
1981年 | 40985篇 |
1980年 | 38453篇 |
1979年 | 44837篇 |
1978年 | 38232篇 |
1977年 | 34912篇 |
1976年 | 31958篇 |
1975年 | 30780篇 |
1974年 | 32474篇 |
1973年 | 31174篇 |
1972年 | 29029篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
971.
Convergent Reliability and Validity of the Questions About Behavioral Function and the Motivation Assessment Scale: A Replication Study 总被引:1,自引:1,他引:0
Karrie A. Shogren Johannes Rojahn 《Journal of developmental and physical disabilities》2003,15(4):367-375
This study compared key psychometric properties of the Motivation Assessment Scale (MAS) and the Questions About Behavioral Function (QABF) and explored their convergent validity. Twenty adults with mental retardation and problem behaviors (aggression, self-injury, or property destruction) and 31 respondents participated. Test–retest reliability of the subscales in both scales was good to excellent (Cicchetti, D. V., 1994, Psychol. Assess. 6: 284–290), and—except for 1 QABF subscale—internal consistency was good considering the small number of items and the purpose of the scale. Consistent with some earlier studies, interrater reliability was less satisfactory with both scales falling only into the fair to good range.Correlations between functionally equivalent subscales were statistically significant and were generally higher than correlations between nonequivalent subscales. The QABF and the MAS were found to be comparable in terms of the assessed reliabilities, and both instruments appear to be measuring very similar constructs. 相似文献
972.
973.
Bone stock preservation is crucial when performing total hip replacement in young patients. The aim is to save good bone stock
for a possible revision procedure. Furthermore, there is an increasing demand from young and active patients to receive a
new joint which allows a normal or nearly normal life style. With this in mind, we began, in 1993, to develop a new femoral
implant. The purpose of this ultra-short stem was a physiologic strain distribution on the proximal femur with a proximal
load transfer from the implant to the femoral bone. Main features were an almost complete absence of the diaphyseal portion
of the stem, a well defined lateral flare with load transfer on the lateral column of the femur, and a very high femoral neck
cut. These innovations resulted in a conservative implant on both the bone stock and the soft tissues. This implant, in the
first years, was recommended only for young and active patients. Over the last thirteen years, this project has undergone
several modifications but the basic principles of the implant have remained the same. In the present review, we present the
rationale, the surgical technique and the clinical and experimental results so far obtained with this implant. 相似文献
974.
M. Parikh M.D. J. Duncombe M.B. B.S. G.A. Fielding M.D. 《Surgery for obesity and related diseases》2006,2(5):99-522
BACKGROUND: Many mild-to-moderately obese individuals (body mass index [BMI] 30-35 kg/m(2)) have serious diseases related to their obesity. Nonoperative therapy is ineffective in the long term, yet surgery has never been made widely available to this population. METHODS: Between 1996 and 2004, 93 patients with a BMI of 30-35 kg/m(2) underwent laparoscopic adjustable gastric banding with the LAP-BAND. All patients were referred by their primary physician, entered into a comprehensive bariatric surgery program at one Australian center, and operated on by one surgeon. Data on all patients were collected prospectively and entered into an electronic registry. The study parameters included preoperative age, gender, BMI, presence of co-morbidities, percentage of excess weight loss, and resolution of co-morbidities. RESULTS: The mean age was 44.6 years (range 16-76), mean weight was 98 kg, and the mean BMI was 32.7 kg/m(2) (range 30-34). Of the 93 patients, 42 (45%) had co-morbidities, including asthma, diabetes, hypertension, and sleep apnea. The proportion of patients in follow-up was 79%, 85%, and 89% at 1, 2, and 3 years, respectively. The mean weight was reduced to 71 kg at 1 year, 72 kg at 2 years, and 72 kg at 3 years. The mean BMI was reduced to 27.2 +/- 2.2, 27.3 +/- 3.1, and 27.6 +/- 3.7 kg/m(2), respectively, and the mean percentage of excess weight loss was 57.9% +/- 24.5%, 57.6 +/- 29.3%, and 53.8% +/- 32.8% at 1, 2, and 3 years, respectively. At 3 years, the BMI was 18-24 kg/m(2) in 34%, 25-29 kg/m(2) in 51%, and 30-35 kg/m(2) in 10%. At 3 years, the percentage of excess weight loss was <25% in 10%, 25-50% in 24%, 50-75% in 51%, and >75% in 10%. The co-morbidities improved or completely resolved in most patients. No mortality occurred. CONCLUSION: We are very encouraged by this series of low BMI patients treated with the LAP-BAND. Their weight loss has been good, the complications have been minimal, and the co-morbidities have partially or wholly resolved. With additional study, it is reasonable to expect the weight guidelines for bariatric surgery to be altered to include patients with a BMI of 30-35 kg/m(2). 相似文献
975.
V. Schmitz U. P. Neumann G. Puhl Z. V. Tran P. Neuhaus J. M. Langrehr 《American journal of transplantation》2006,6(2):379-385
Choledochojejunostomy (CJS) is commonly used for biliary reconstruction in liver transplantation for primary sclerosing cholangitis (PSC). We alternatively performed choledochoduodenostomy (CDS) and side-to-side choledochodocholedochstomy in a large cohort of patients. Fifty-one patients with PSC, transplanted between 1988 and 2000, were analyzed retrospectively. Biliary reconstruction was CDS in 25 (49%), CJS in 20 (39%) and CC in 6 transplantations (12%). Biliary leaks occurred in the early follow-up (< or =41 days) only in CDS patients (20%). However, in the late follow-up (>4 months), stricturing of anastomosis was found once in CDS (4%) and CJS (5%). Later (>9 months), intrahepatic bile duct strictures were diagnosed in four CDS (16%), one CJS (5%) and one CC (17%) patient(s). In 48% of CDS (12/25), 60% of CJS (12/20) and 17% of CC (1/6) at least one incidence of cholangitis was observed. Overall, biliary complication rates were significantly higher in CDS (40%) than CJS (10%) and CC (17%); of those none in CC and 12% in CDS were anastomosis-related. Graft/patient survival showed no significant differences among groups. Based on our results we consider CJS the standard method for biliary reconstruction in PSC; however, in selected cases where CJS is difficult to accomplish because of previous surgery or for retransplantation, CDS may present an alternative technique. 相似文献
976.
The precise molecular cause of insulin resistance has not yet been elucidated. Resistance to the normal action of insulin contributes to the pathogenesis of a number of common human disorders, including type 1 (insulin-dependent) and type 2 (non-insulin-dependent) diabetes mellitus, hypertension, and the Metabolic Syndrome X, thus constituting a major public health problem. A disease program aimed at combating this disorder should focus on the identification of targets for therapeutic intervention which may overcome insulin resistance and hence the associated metabolic consequences characteristic of the Metabolic Syndrome. Although the primary defect in the pathogenesis of type 2 diabetes is unknown, genetic and environmental factors are likely to contribute to the manifestation of this progressive metabolic disorder, which is usually not clinically apparent until mid-life. Defects at the level of glucose uptake/phosphorylation characterize insulin resistance in skeletal muscle of type 2 diabetic patients. Identification of putative components of the insulin receptor-signaling pathway may offer insights into mechanisms involved in insulin resistance. Enhanced flux of free fatty acids due to impaired lipid metabolism may contribute to impaired insulin secretion and peripheral insulin resistance. Genes regulating lipolysis are prime candidates for susceptibility towards the metabolic syndrome. Here we describe pathways constituting complex interactions that control glucose homeostasis. We will be considering (1) regulation of glucose uptake by the insulin receptor signaling pathway, and (2) control of adipogenesis and insulin sensitivity by the sterol response element binding protein (SREBP) pathway. 相似文献
977.
978.
979.
980.