新华社区部分高血压患者危险因素分析

目的 了解本社区高血压患者的危险因素现状，探讨干预对策。方法 采用分层整群抽样的方法，随机抽取社区4个里委2级、3级高血压患者402例作为研究对象，收集各项危险因素如性别、年龄、血脂、血糖、吸烟、饮食、体育锻炼、体重等，并进行统计分析。结果402例高血压患者1年内进行所有相关辅助检查者有14例，占3．48％；1年内进行相关辅助检查一项者306例，占76．12％。饮食控制及进行体育锻炼有300例，占74．43％；吸烟62例，占15．42％。结论 高血压患者对饮食控制及体育锻炼、吸烟有害的知晓率明显提高，而对相关辅助检查认识不足。     

Why study transport of peptides and proteins at the neurovascular interface

The blood–brain barrier (BBB) is an immense neurovascular interface. In neurodegenerative, ischemic, and traumatic disorders of the central nervous system (CNS), the BBB may hinder the delivery of many therapeutic peptides and proteins to the brain and spinal cord. Fortunately, the mistaken dogma that peptides and proteins do not cross the BBB has been corrected during the past two decades by the accumulating evidence that peptides and proteins in the periphery exert potent effects in the CNS. Not only can peptides and proteins serve as carriers for selective therapeutic agents, but they themselves may directly cross the BBB after delivery into the bloodstream. Their passage may be mediated by simple diffusion or specific transport, both of which can be affected by interactions in the blood compartment (outside the BBB) and within the endothelial cells (at the BBB level). Although the majority of current delivery strategies focuses on modification of the molecule to be delivered, understanding the mechanisms of transport will eventually facilitate regulation of the BBB directly. We review the different aspects of interactions and discuss recent advances in the cell biology of peptide/protein transport across the BBB. Better understanding of the nature and regulation of the transport systems at the BBB will provide a new direction to enhance the interactions of peripheral peptides and proteins with the CNS.     

血卟啉在H-22肝癌荷瘤小鼠体内的分布

目的探讨声敏剂血卟啉衍生物在肿瘤组织中的富集情况,以便在给药后超声结合血卟啉治疗肿瘤时选择最佳的超声处理时间。方法H-22肝癌荷瘤小鼠尾静脉注射HpD后,不同时间点取材,采用荧光分光光度法测定不同组织提取液中HpD的荧光强度,研究HpD在不同组织中的分布以及代谢变化。结果给药后2 h肿瘤组织以外的其他各组织内(血浆、肝、肾、皮肤、肌肉)血卟啉含量均达到其代谢过程的最高点,后逐渐下降;肿瘤组织中的HpD含量注射后不断上升,6 h时达到顶峰,随后又开始下降,10~24 h代谢比较缓慢,表现为肿瘤组织中对HpD的滞留作用,24 h时肿瘤组织中的HpD含量高于其他各组织,48~72 h趋于稳定在较低水平。结论提出了不同部位的肿瘤应选择各自适当的时间点进行超声处理。     

XD—1型微电脑程序刺激器在心血管病中的临床应用

本文应用XD—Ⅰ型微电脑程序刺激器检查26例患者,在窦房结功能检查中测定了窦房结恢复时间、窦房传导时间及固有心率;在房室传导功能的估计中测定了文氏点,2∶1阻滞点及房室结的有效不应期;在室上性心动过速中测定了旁路不应期,房室结双通道,折返区及折返性心动过速区;还进行了心脏负荷试验及右束支不应期等方面的测定。并就其方法,判断标准及临床意义等分别作了讨论。     

The use of the facial translocation technique in the management of tumors of the paranasal sinuses and skull base.

OBJECTIVE: We sought to assess the efficacy of facial translocation in the management of tumors of the skull base and paranasal sinuses. STUDY DESIGN AND SETTING: From July 1993 to December 1999, 75 patients, aged 3 to 102 years old, underwent facial translocation. Thirty-three (44%) patients also underwent a combined neurosurgical procedure. Nineteen (25%) had previous surgery. These patients were followed up to 6 years. RESULTS: There were 21 benign and 54 malignant tumors. There were no perioperative deaths. The morbidity rate was 31%. Of the 54 patients with malignant tumors, the actuarial 3-year survival rate was 59%, whereas the local control rate was 54%. CONCLUSION: The facial translocation technique offers favorable exposure of the critical zones of the anterior and middle cranial base, thus facilitating extensive resection and reconstruction. SIGNIFICANCE: This study demonstrates that facial translocation is one of the best surgical approaches to the skull base.     

人晶体 γ-晶体蛋白的研究:Ⅳ.近紫外线对胚 γ_2-晶体蛋白的光氧化作用

对人胚胎晶体γ_2-晶体蛋白溶液用近紫外线(γmax 365nm)照射,不同时间取样分析。利用巯基(-SH)特异性试剂 DACM[N-(7-甲基氨基-4-甲基-3-邻羟苯烯基)-马来酰亚胺],经 SDS-聚丙烯酰胺凝胶电泳观察光照射后的γ_2-晶体蛋白及其聚合物的游离巯基,同时检测照射后的蛋白溶液的紫外吸收光谱、光散射强度、色氨酸荧光发射光谱,以及丙烯酰胺对色氨酸荧光的猝灭效应。结果显示:人胚胎γ_2-晶体蛋白经紫外线照射,使其游离-SH 减少,蛋白聚合和分解,蛋白溶液的光散射增强,其二聚体不含游离-SH,γ_2-晶体蛋白的色氨酸荧光减少,这些变化随照射时间的延长而更明显;而对丙烯酰胺对蛋白分子中的色氨酸荧光猝灭效应影响不大。说明人胚胎γ_2-晶体蛋白通过光氧化,损伤及含游离-SH 的氨基酸残基、色氨酸残基,光氧化促使蛋白聚合和分解.提出通过进一步定量分析,可能在较深层次揭示紫外光氧化损伤含-SH 氨基酸、色氨酸残基,进而影响整个蛋白质分子结构的差异。眼科学报 1993;9:85-89。     

Ligase chain reaction for diagnosis of familial hypertrophic cardiomyopathy

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白内障显微囊外摘除联合小梁切除术

报告20例(21眼)青光眼白内障并存患者采用显微囊外摘除联合小梁切除术.术后眼压控制满意,滤过泡形成,视力不同程度提高,无明显并发症.并对有关机制,手术优点及不易控制的眼压问题进行了讨论.