全文获取类型
收费全文 | 88952篇 |
免费 | 41571篇 |
国内免费 | 61篇 |
专业分类
耳鼻咽喉 | 1593篇 |
儿科学 | 4571篇 |
妇产科学 | 883篇 |
基础医学 | 16991篇 |
口腔科学 | 5230篇 |
临床医学 | 14544篇 |
内科学 | 24829篇 |
皮肤病学 | 7605篇 |
神经病学 | 14426篇 |
特种医学 | 2460篇 |
外国民族医学 | 1篇 |
外科学 | 14640篇 |
综合类 | 137篇 |
一般理论 | 37篇 |
预防医学 | 5864篇 |
眼科学 | 1415篇 |
药学 | 6325篇 |
1篇 | |
中国医学 | 1021篇 |
肿瘤学 | 8011篇 |
出版年
2023年 | 70篇 |
2022年 | 131篇 |
2021年 | 1517篇 |
2020年 | 5171篇 |
2019年 | 11064篇 |
2018年 | 10284篇 |
2017年 | 11608篇 |
2016年 | 12307篇 |
2015年 | 12199篇 |
2014年 | 12240篇 |
2013年 | 12866篇 |
2012年 | 5069篇 |
2011年 | 4953篇 |
2010年 | 9369篇 |
2009年 | 5683篇 |
2008年 | 2859篇 |
2007年 | 1779篇 |
2006年 | 1757篇 |
2005年 | 1479篇 |
2004年 | 1474篇 |
2003年 | 1382篇 |
2002年 | 1546篇 |
2001年 | 854篇 |
2000年 | 758篇 |
1999年 | 368篇 |
1998年 | 208篇 |
1997年 | 173篇 |
1996年 | 148篇 |
1995年 | 121篇 |
1994年 | 94篇 |
1993年 | 108篇 |
1992年 | 62篇 |
1991年 | 62篇 |
1990年 | 46篇 |
1989年 | 66篇 |
1988年 | 33篇 |
1987年 | 32篇 |
1986年 | 52篇 |
1985年 | 34篇 |
1984年 | 65篇 |
1983年 | 46篇 |
1982年 | 60篇 |
1981年 | 47篇 |
1980年 | 41篇 |
1979年 | 34篇 |
1978年 | 41篇 |
1977年 | 31篇 |
1976年 | 21篇 |
1974年 | 23篇 |
1973年 | 19篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
111.
Dry skin (xerosis) is a common dermatosis affecting people of varying skin types and ages and various areas of the body. It is associated with both skin thickening and skin thinning and is triggered by both exogenous (e.g. climate, environment, lifestyle) and endogenous (e.g. medication, hormone fluctuations, organ diseases) factors. Skin requires a water content of 10–15% to remain supple and intact. This water is either ‘static’ (i.e. bound) or ‘dynamic’. The predominance of hydrophobic substances in intercellular constituents is a means of regulating the humidity of the skin. Emollients, highly effective treatment adjuncts in the management of all dry skin disorders, help to restore damaged intercorneocyte lipid structures and increase the water content of the skin, helping to reduce scaling and improving its barrier function. 相似文献
112.
113.
Leslee J. Shaw Romalisa Miranda-Peats Piotr Slomka John Friedman Sean W. Hayes Daniel S. Berman Gary V. Heller Marcin Dada William E. Boden Paul Casperson Robert A. O’Rourke Ronald Schwartz William S. Weintraub David J. Maron Spencer King Koon Teo Pamela Hartigan 《Journal of nuclear cardiology》2006,13(5):685-698
Background Stress gated myocardial perfusion single photon emission computed tomography (gSPECT) is increasingly used before and after
intercurrent therapeutic intervention and is the basis for ongoing evaluation in the Department of Veterans Affairs clinical
outcomes utilizing revascularization and aggressive drug evaluation (COURAGE) trial.
Methods and Results The COURAGE trial is a North American multicenter randomized clinical trial that enrolled 2287 patients to aggressive medical
therapy vs percutaneous coronary intervention plus aggressive medical therapy. Three COURAGE nuclear substudies have been
designed. The goals of substudy 0 are to examine the diagnostic accuracy of the extent and severity of inducible ischemia
at baseline in COURAGE patients compared with patient symptoms and quantitative coronary angiography and to explore the relationship
between inducible ischemia and the benefit from revascularization when added to medical therapy. Substudy 1 will correlate
the extent and severity of provocative ischemia with the frequency, quality, and instability of recurrent symptoms in postcatheterization
patients. Substudy 2 (n _ 300) will examine the usefulness of sequential gSPECT monitoring 6 to 18 months after therapeutic
intervention. Together, these nuclear substudies will evaluate the role of gSPECT to determine the effectiveness of aggressive
risk-factor modifications, lifestyle interventions, and anti-ischemic medical therapies with or without revascularization
in reducing patients’ ischemic burdens.
Conclusions The unfolding of evidence on the application of gSPECT in trials such as COURAGE defines a new era for nuclear cardiology.
We hope the evidence that emerges from the COURAGE trial will further establish the role of nuclear imaging in the evidence-based
management of patients with stable coronary disease.
The COURAGE trial was supported by the Cooperative Studies Program of the Department of Veterans Affairs Office of Research
and Development in collaboration with the Canadian Institutes of Health Research. Unrestricted research grants were obtained
from Merck & Co; Pfizer Pharmaceuticals; Bristol-Myers Squibb Medical Imaging; Astellas Pharma; Kos Pharmaceuticals; Data
Scope; Astra Zeneca Pharmaceuticals; Astra-Zeneca-Canada; Schering-Plough Coorporation, Ltd; Sanofi-Aventis, Inc; First Horizon;
and GE Healthcare. All industrial funding for this trial was directed through the Department of Veterans Affairs. Additional
funding for this substudy was provided by grants to the Department of Veterans Affairs and Canadian Institutes of Health Research
from Astellas Pharma and Bristol-Myers-Squibb Medical Imaging. 相似文献
114.
115.
116.
Jing‐Ping Zhang Limin Zheng Jiang‐Hai Wang Karl‐Eric Magnusson Xin Liu 《Phytotherapy research : PTR》2009,23(6):844-850
Ganoderma sinensis has been used widely in Oriental countries for the prevention and treatment of various diseases including cancer. Previous studies have shown that the lipid extract from Ganoderma exhibits direct cytotoxicity against tumor cells. Here, it is reported that the lipid extract from germinating G. sinensis spores, at lower concentrations that have no direct tumoricidal activity, induce potent antitumor immune responses in human monocytes/macrophages. Upon stimulation with the lipid extract, monocytes/macrophages exhibited markedly increased production of proinflammatory cytokines and surface expression of costimulatory molecules. Conditioned medium from stimulated cells effectively suppressed the growth of tumor cells. Apparently, the lipid extract triggered macrophage activation via a mechanism different from that associated with LPS. Moreover, it was observed that the lipid extract could partially re‐establish the antitumor activity of the immunosuppressive tumor‐associated macrophages. These results indicated that in addition to its direct tumoricidal activity, the lipid extract from G. sinensis spores could exert antitumor activity by stimulating the activation of human monocytes/macrophages. Copyright © 2008 John Wiley & Sons, Ltd. 相似文献
117.
118.
119.
Henry Ho‐Lung Chan 《Clinical & experimental optometry》2005,88(6):410-414
The first‐order kernel analysis in multifocal electroretinogram (mfERG) using low contrast stimulation is suggested as a way to detect the inner retinal responses in animal studies. In this case report, this protocol is applied to human patients with glaucoma to demonstrate the possibility of using mfERG as a tool to detect glaucomatous damage. Two patients with glaucoma were recruited and had mfERG measurements with the 103‐scaled hexagonal stimulus pattern at low (50 per cent) contrast. Their responses were analysed and compared with those from normal subjects with the mfERG measured under the same condition. In the normal subjects, there were obvious oscillatory components on the ascending and descending limbs of the first‐order kernel response to 50 per cent contrast. In the glaucomatous patients, the oscillatory component on the descending limb was obviously diminished. In addition, this component was significantly diminished in the quadrant with a glaucomatous visual field defect. This suggests that the low‐contrast stimulation condition in mERG measurement may provide a good way to detect glaucomatous damage and this may help in clinical diagnosis of glaucoma. 相似文献
120.