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Douglas L. Miller Xiaofang Lu Chunyan Dou Yiying I. Zhu Rachael Fuller Kristina Fields Mario L. Fabiilli Gabe E. Owens David Gordon Oliver D. Kripfgans 《Ultrasound in medicine & biology》2018,44(7):1439-1450
Ultrasound myocardial cavitation-enabled treatment was applied to the SS-16BN rat model of hypertrophic cardiomyopathy for proof of the principle underlying myocardial reduction therapy. A focused ultrasound transducer was targeted using 10-MHz imaging (10 S, GE Vivid 7) to the left ventricular wall of anesthetized rats in a warmed water bath. Pulse bursts of 4-MPa peak rarefactional pressure amplitude were intermittently triggered 1:8 heartbeats during a 10-min infusion of a microbubble suspension. Methylprednisolone was given to reduce initial inflammation, and Losartan was given to reduce fibrosis in the healing tissue. At 28 d post therapy, myocardial cavitation-enabled treatment significantly reduced the targeted wall thickness by 16.2% (p?<0.01) relative to shams, with myocardial strain rate and endocardial displacement reduced by 34% and 29%, respectively, which are sufficient for therapeutic treatment. Premature electrocardiogram complexes and plasma troponin measurements were found to identify optimal and suboptimal treatment cohorts and would aid in achieving the desired impact. With clinical translation, myocardial cavitation-enabled treatment should fill the need for a new non-invasive hypertrophic cardiomyopathy therapy option. 相似文献
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Pulmonary hypertension: Barrier or just a bump in the road in transplanting adults with congenital heart disease
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Jonathan N. Menachem MD Edo Y. Birati MD Payman Zamani MD Anjali T. Owens MD Pavan Atluri MD Christian A. Bermudez MD David Drajpuch NP Stephanie Fuller MD Yuli Y. Kim MD Christopher E. Mascio MD Vikram Palanivel MD J. Eduardo Rame MD Joyce Wald DO Michael A. Acker MD Jeremy A. Mazurek MD 《Congenital heart disease》2018,13(4):492-498
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Nicholas Booth Christabel Owens 《International review of psychiatry (Abingdon, England)》2013,25(1):27-30
The evidence relating postpartum mood disorder to endocrine factors is reviewed, with particular reference to thyroid hormones, progesterone, cortisol and oestrogen. The findings on non-psychotic depression and thyroid dysfunction are the most robust, but such biological changes have to be seen as interacting with psychological and social factors to produce depression. Hormone treatment trials in specific subgroups of postnatal women would enhance our understanding of aetiology 相似文献
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The epidermis of the skin is a multilayered stratified epithelium whose primary function is to provide a barrier against our external environment. As a result, cells in the epidermis are subject to constant assault from environmental pathogens, many of which can cause deleterious mutations. However, most of these mutations do not lead to skin cancer. One explanation is that most genetic hits are sustained by mature or transit cells with limited proliferative capacity and only stem cells that acquire genetic alterations have the potential to propagate a frank tumor. In this mini-review we will discuss recent studies that provide some of the first genetic evidence to support a stem cell origin for a number of skin cancer types. 相似文献
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