全文获取类型
收费全文 | 32543篇 |
免费 | 1697篇 |
国内免费 | 73篇 |
专业分类
耳鼻咽喉 | 428篇 |
儿科学 | 1259篇 |
妇产科学 | 592篇 |
基础医学 | 4030篇 |
口腔科学 | 640篇 |
临床医学 | 2201篇 |
内科学 | 8467篇 |
皮肤病学 | 982篇 |
神经病学 | 2906篇 |
特种医学 | 914篇 |
外科学 | 4991篇 |
综合类 | 150篇 |
一般理论 | 6篇 |
预防医学 | 2722篇 |
眼科学 | 614篇 |
药学 | 1719篇 |
中国医学 | 109篇 |
肿瘤学 | 1583篇 |
出版年
2023年 | 187篇 |
2022年 | 154篇 |
2021年 | 746篇 |
2020年 | 347篇 |
2019年 | 808篇 |
2018年 | 1209篇 |
2017年 | 698篇 |
2016年 | 676篇 |
2015年 | 707篇 |
2014年 | 846篇 |
2013年 | 1332篇 |
2012年 | 2176篇 |
2011年 | 2375篇 |
2010年 | 1241篇 |
2009年 | 967篇 |
2008年 | 1944篇 |
2007年 | 2077篇 |
2006年 | 1988篇 |
2005年 | 1965篇 |
2004年 | 1861篇 |
2003年 | 1665篇 |
2002年 | 1644篇 |
2001年 | 1053篇 |
2000年 | 1276篇 |
1999年 | 920篇 |
1998年 | 173篇 |
1997年 | 116篇 |
1996年 | 121篇 |
1995年 | 78篇 |
1994年 | 71篇 |
1993年 | 65篇 |
1992年 | 338篇 |
1991年 | 260篇 |
1990年 | 267篇 |
1989年 | 186篇 |
1988年 | 142篇 |
1987年 | 133篇 |
1986年 | 140篇 |
1985年 | 111篇 |
1984年 | 97篇 |
1983年 | 70篇 |
1982年 | 50篇 |
1981年 | 46篇 |
1979年 | 42篇 |
1974年 | 69篇 |
1973年 | 67篇 |
1972年 | 45篇 |
1971年 | 47篇 |
1970年 | 45篇 |
1969年 | 48篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
981.
982.
Lázaro Saéz M Hernández Martínez A Bendezú García RÁ Rodríguez Manrique MA Simón López F Medina Estévez E Vega Sáenz JL 《Gastroenterologia y hepatologia》2012,35(5):321-325
Inflammatory bowel disease is accompanied by extraintestinal manifestations in a high percentage of patients. Cutaneous lesions are the second most prevalent of these manifestations, and within these, metastatic Crohn's disease is one of the least common, being the least frequent specific cutaneous manifestation of Crohn's disease. This entity includes cutaneous and subcutaneous lesions with a non-caseating granulomatous appearance on histological analysis identical to that of Crohn's disease. These lesions are not found adjacent to the digestive tract. Due to the low prevalence of these manifestations, conclusive trials on the treatment of choice have not been performed and there is no well-defined therapeutic strategy. Distinct therapies with varying results have been reported. We report the case of a female patient with longstanding and complex Crohn's disease who developed metastatic cutaneous manifestations while receiving adalimumab. The cutaneous manifestations responded well to dose intensification of this drug. A review of the literature is provided. 相似文献
983.
Senosiain Lalastra C Martínez González J Mesonero Gismero F Moreira Vicente V 《Gastroenterologia y hepatologia》2012,35(8):567-571
Chylous ascites is infequent after abdominal surgery. We describe the case of a 43-year-old man with portal cavernomatosis who underwent surgery to insert a splenorenal shunt, which was not placed due to the absence of signs of portal hypertension. On postoperative day 20, the patient developed abdominal distension and mild dyspnea and was diagnosed with chylous ascites, which was related to the surgery. The patient was initially treated with diet and diuretics, with no clinical response, and consequently octreotide therapy was started. Four days later, the ascites was almost resolved and an ultrasound scan at 4 months showed its complete disappearance. This article demonstrates the effectiveness of octreotide in the treatment of postsurgical chylous ascites. 相似文献
984.
985.
986.
987.
988.
989.
Sanz J Boluda JC Martín C González M Ferrá C Serrano D de Heredia CD Barrenetxea C Martinez AM Solano C Sanz MA Sanz GF 《Bone marrow transplantation》2012,47(10):1287-1293
Attempts to optimize outcomes in cord blood transplantation (CBT) by using new conditioning regimens and standardization of cord blood unit selection are warranted. In all, 88 patients (18 children and 70 adults) with hematological malignancy from nine Spanish institutions underwent a single-unit CBT after an i.v. BU-based myeloablative conditioning regimen. All evaluable patients except one engrafted. The overall cumulative incidence (CI) of myeloid engraftment was 94% at a median time of 19 days. In multivariate analysis, nonadvanced disease stage was the only factor with a favorable impact on myeloid engraftment. The CI of acute GVHD grades II-IV and chronic extensive GVHD were 24% each. The CI of nonrelapse mortality at 100 days, 180 days and 5 years was 14, 23 and 44%, respectively. The 5-year CI of relapse was 18%, whereas disease-free survival (DFS) was 46%, 39% and 11% for patients transplanted in early, intermediate and advanced stages of the disease, respectively. Our study shows high rates of engraftment with fast neutrophil recovery in patients undergoing single-unit CBT using a BU-based conditioning regimen. Long-term DFS can be achieved in a substantial number of patients with high-risk hematological malignancies, particularly when transplanted in an early stage of the disease. 相似文献
990.
Martín-Antonio B Álvarez-Laderas I Cardesa R Márquez-Malaver F Baez A Carmona M Falantes J Suarez-Lledo M Fernández-Avilés F Martínez C Rovira M Espigado I Urbano-Ispizua Á 《Bone marrow transplantation》2012,47(9):1206-1211
An adequate response of the innate immune system after allo-SCT is crucial for the clinical outcome of patients submitted to this procedure. EP300 is one of the key genes of the innate immune system (IIS). We evaluated the influence of gene variant A>G rs20551 in EP300 in donor and/or recipient on clinical results after HLA-identical sibling allo-SCT. Patients with AA gene variant had a lower relapse incidence (31 vs 48%, P=0.025; odds ratio (OR)=1.6, P=0.05), attained better disease-free survival (AA: 53% vs AG+GG: 24%, P=0.001; OR=1.8, P=0.01), and better OS (AA: 53% vs AG+GG: 34%, P=0.001; OR=1.9, P=0.007). This beneficial association was more evident when AA gene variant was present in both donor and patient. In healthy individuals, AA gene variant was associated with lower IL2 production after a mitogenic stimuli, higher CD4+ cell response after CMV infection, and higher expression of innate immune genes (IRF-3 and MIF), cell cycle genes (AURKB, CCNA2 and CCNB1), lymphocyte survival genes (NFAT5 and SLC38A2), and with a lower expression of P53 compared with recessive GG gene variant. These findings suggest a beneficial effect of the AA gene variant in rs20551 on clinical outcome after allo-SCT. 相似文献