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101.
M. Rozenblat Y. Pessach A. Gat R. Bergman E. Sprecher I. Goldberg 《Clinical and experimental dermatology》2013,38(7):748-750
Reactive angioendotheliomatosis (RAE) is a diagnostically challenging condition characterized by multiple possible clinical presentations, which makes diagnosis challenging. We present a rare case of RAE mimicking cellulitis in a 74‐year‐old woman with a valvular disease and also end‐stage renal disease, for which she was being treated with haemodialysis. 相似文献
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Hiba Zaaroura Yuval Geffen Reuven Bergman Emily Avitan‐Hersh 《The Journal of dermatology》2018,45(8):994-999
Staphylococcus lugdunensis is an emerging pathogen in skin and soft tissue infections that was previously considered a commensal. The aim of this study was to elucidate the characteristics of skin infections by S. lugdunensis and its appropriate management, in a tertiary referral medical center. The clinical files, bacterial cultures and histopathology reports of all S. lugdunensis isolates from skin infections over a period of 8 years (September 2009–September 2017) were reviewed. S. lugdunensis was isolated from 29 patients with skin infections, aged 7–89 years (mean 33.3 years). A state of immune suppression (drug‐induced, malignancy or diabetes) was present in five patients (17%). Folliculitis and cutaneous pustulosis were the most common presentations (16 cases, 55%), followed by secondary infection of hidradenitis suppurativa (five cases, 17%). Other sources of isolation were infected molluscum contagiosum (two cases), folliculitis decalvans (one case), dissecting cellulitis (one case), abscess (one case), cyst (one case), impetigo (one case) and granuloma after trauma (one case). The in vitro antibiotic sensitivity tests showed susceptibility to most tested antibiotics, although a few isolates were resistant to gentamycin, penicillin and oxacillin. In 19 of 20 patients for whom follow ups were available, cutaneous manifestations improved or resolved with proper local and/or oral antibiotic therapy. S. lugdunensis may play a role as a primary or secondary pathogen in various skin infections, most commonly folliculitis and pustulosis. Proper antibiotic therapy may lead to improvement or resolution. 相似文献
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Cell Therapeutics in Parkinson’s Disease 总被引:1,自引:0,他引:1
The main pathology underlying motor symptoms in Parkinson’s disease (PD) is a rather selective degeneration of nigrostriatal
dopamine (DA) neurons. Intrastriatal transplantation of immature DA neurons, which replace those neurons that have died, leads
to functional restoration in animal models of PD. Here we describe how far the clinical translation of the DA neuron replacement
strategy has advanced. We briefly summarize the lessons learned from the early clinical trials with grafts of human fetal
mesencephalic tissue, and discuss recent findings suggesting susceptibility of these grafts to the disease process long-term
after implantation. Mechanisms underlying graft-induced dyskinesias, which constitute the only significant adverse event observed
after neural transplantation, and how they should be prevented and treated are described. We summarize the attempts to generate
DA neurons from stem cells of various sources and patient-specific DA neurons from fully differentiated somatic cells, with
particular emphasis on the requirements of these cells to be useful in the clinical setting. The rationale for the new clinical
trial with transplantation of fetal mesencephalic tissue is described. Finally, we discuss the scientific and clinical advancements
that will be necessary to develop a competitive cell therapy for PD patients. 相似文献
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