全文获取类型
收费全文 | 62篇 |
免费 | 5篇 |
专业分类
儿科学 | 8篇 |
妇产科学 | 2篇 |
基础医学 | 11篇 |
口腔科学 | 1篇 |
临床医学 | 7篇 |
内科学 | 5篇 |
皮肤病学 | 2篇 |
神经病学 | 6篇 |
特种医学 | 7篇 |
外科学 | 3篇 |
预防医学 | 3篇 |
眼科学 | 4篇 |
药学 | 6篇 |
肿瘤学 | 2篇 |
出版年
2023年 | 1篇 |
2021年 | 2篇 |
2017年 | 1篇 |
2016年 | 1篇 |
2015年 | 2篇 |
2014年 | 1篇 |
2013年 | 3篇 |
2011年 | 2篇 |
2010年 | 2篇 |
2009年 | 3篇 |
2008年 | 4篇 |
2007年 | 1篇 |
2006年 | 2篇 |
2005年 | 1篇 |
2001年 | 1篇 |
1998年 | 6篇 |
1997年 | 11篇 |
1996年 | 4篇 |
1995年 | 1篇 |
1994年 | 2篇 |
1993年 | 1篇 |
1992年 | 1篇 |
1991年 | 1篇 |
1986年 | 1篇 |
1985年 | 1篇 |
1980年 | 1篇 |
1979年 | 1篇 |
1978年 | 2篇 |
1977年 | 1篇 |
1976年 | 3篇 |
1975年 | 1篇 |
1967年 | 1篇 |
1965年 | 1篇 |
排序方式: 共有67条查询结果,搜索用时 15 毫秒
21.
JM Davis WN Rosenfeld SE Richter MR Parad IH Gewolb AR Spitzer WA Carlo RJ Couser A Price E Flaster N Kassem L Edwards J Tierney S Horowitz 《Pediatrics》1997,100(1):24-30
OBJECTIVES: To examine the safety and pharmacokinetics of multiple intratracheal (IT) doses of recombinant human CuZn superoxide dismutase (rhSOD) in premature infants with respiratory distress syndrome who are at risk for developing bronchopulmonary dysplasia (BPD). Methods. Thirty-three infants (700 to 1300 g) were randomized and blindly received saline, 2.5 mg/kg or 5 mg/kg rhSOD IT within 2 hours of surfactant administration. Infants were treated every 48 hours (as long as endotracheal intubation was required) up to 7 doses. Serial blood and urine studies, chest radiographs, neurosonograms, SOD concentration and activity measurements, and tracheal aspirate (TA) inflammatory markers were assessed throughout the 28-day study. RESULTS: SOD concentrations in serum (0.1 [0.05/0.15] microg/mL-geometric mean with lower/upper confidence intervals), tracheal aspirates (TA) (0.2 [0.1/0.3] microg/mL) and urine (0.3 [0.2/0.4] microg/mL) were similar at baseline in all 3 groups and did not change significantly in the placebo group. In the rhSOD treatment groups, SOD concentrations were increased on day 3 and did not change significantly thereafter over the 14-day dosing period (also measured on days 5, 7, and 13). SOD concentrations averaged 0.4 [0.3/0.5] microg/mL in serum, 0.8 [0.6/1.2] microg/mL in TA and 1.1 [1.0/1.3] microg/mL in urine for the low-dose group and 0.6 [0.5/0.7] microg/mL in serum, 1.1 [0.9/1.5] microg/mL in TA, and 2.2 [1.6/2.9] microg/mL in urine for the high-dose group over the 14-day dosing period. Enzyme activity directly correlated with SOD concentration and rhSOD was active even when excreted in urine. TA markers of acute lung injury (neutrophil chemotactic activity, albumin concentration) were lower in the rhSOD agroups compared with placebo. No significant differences in any clinical outcome variable were noted between groups. CONCLUSIONS: These data indicate that multiple IT doses of rhSOD increase the concentration and activity of the enzyme in serum, TA and urine, reduce TA lung injury markers and are well-tolerated. Further clinical trials examining the efficacy of rhSOD in the prevention of BPD are warranted. 相似文献
22.
Chorionic gonadotropin inhibits rat mammary carcinogenesis through activation of programmed cell death 总被引:3,自引:2,他引:3
Human chorionic gonadotropin (hCG) inhibits the progression of 7,12-
dimethylbenz[a]anthracene (DMBA) induced mammary carcinomas. In order to
determine whether this phenomenon was mediated by induction of programmed
cell death or apoptosis, 45-day-old virgin Sprague-Dawley rats received 8
mg DMBA/100 g body weight; 20 days later they were injected daily with 100
IU hCG for 40 days (DMBA + hCG group). Age- matched untreated, hCG- and
DMBA + saline treated rats were used as controls. Tissues were collected at
the time of DMBA administration and at 5, 10, 20 and 40 days of hCG
injection. RNA from mammary glands, adenocarcinomas and ovaries was probed
for transforming growth factors (TGF) alpha and beta, and the apoptotic
genes TRPM2, ICE, bcl2, bcl-XL, bcl-XS, p53 and c-myc. The mammary glands
of hCG-treated animals with or without DMBA exhibited elevated expression
of TRPM2, ICE, bcl-XS, c- myc and p53; and elevation in the apoptotic
index. Mammary adenocarcinomas developed in those animals treated with hCG
showed an elevation in the expression of p53, c-myc and ICE genes in
comparison with the levels detected in the adenocarcinomas developed by the
animals treated with DMBA alone. No significant alterations in the
expression of any of the genes tested was observed in ovarian RNAs. These
results led us to conclude that hCG induces programmed cell death in the
mammary gland initiated in the carcinogenic process, that this process is
p53 dependent, and is modulated by c-myc expression. Our data also indicate
the possibility that a cell death program dependent on the bcl2 family
exists, because of the potential involvement of p53, bcl-XS and Bax in
apoptosis. This additional mechanism of tumor inhibition makes hCG
treatment a useful approach for the prevention and therapy of breast
cancer.
相似文献
23.
Cloning and characterization of DXS6673E, a candidate gene for X-linked mental retardation in Xq13.1 总被引:3,自引:0,他引:3
van der Maarel SM; Scholten IH; Huber I; Philippe C; Suijkerbuijk RF; Gilgenkrantz S; Kere J; Cremers FP; Ropers HH 《Human molecular genetics》1996,5(7):887-897
In several families with non-specific X-linked mental retardation (XLMR)
linkage analyses have assigned the underlying gene defect to the
pericentromeric region of the X chromosome, but none of these genes have
been isolated so far. Here, we report on the cloning and characterization
of a novel gene, DXS6673E, that maps to Xq13.1, is subject to
X-inactivation and is disrupted in the 5' untranslated region by a balanced
X;13 translocation in a mentally retarded female. The DXS6673E gene is
highly conserved among vertebrates and its expression is most abundant in
brain. It encodes a hydrophilic protein of 1358 amino acids (aa) that does
not show sequence homology to other known proteins. A segment of this
protein consisting of neutral and hydrophobic aa with a proline residue in
every second position may represent a transmembrane domain. Almost complete
sequence identity was found between the 3' end of the DXS6673E gene and two
expressed sequence tags (ESTs) and between the 5' end of the DXS6673E gene
and a third EST. Moreover, weaker sequence similarity was observed between
coding regions and two other ESTs.
相似文献
24.
JAJM van den Hurk M Schwartz H van Bokhoven TJR van de Pol L Bogerd AJLG Pinckers EM Bleeker-Wagemakers IH Pawlowitzki K Rüther H-H Ropers FPM Cremers 《Human mutation》1997,9(2):110-117
Choroideremia (CHM) is an X-linked recessive eye disease that results from mutations involving the Rab escort protein-1 (REP-1) gene. In 18 patients deletions of different sizes have been found. Two females suffering from CHM were reported to have translocations that disrupt the REP-1 gene. In 22 patients, small mutations have been identified. Interestingly, these are all nonsense, frameshift or splice-site mutations; with one possible exception, missense mutations have not been found. This comprises all the known mutations in the disease. Hum Mutat 9:110–117, 1997. © 1997 Wiley-Liss, Inc. 相似文献
25.
Jacq K Delaney E Teasdale A Eyley S Taylor-Worth K Lipczynski A Reif VD Elder DP Facchine KL Golec S Oestrich RS Sandra P David F 《Journal of pharmaceutical and biomedical analysis》2008,48(5):1339-1344
An automated sample preparation and analysis procedure was developed to monitor the formation of ethyl methane sulfonate from reaction mixtures containing ethanol and methane sulfonic acid. The system is based on a liquid handling robot combined with a static headspace module. The formed ethyl methane sulfonate is analysed after derivatisation with pentafluorothiophenol using static headspace-gas chromatography–mass spectrometry (SHS-GC–MS).Using the automated reaction–derivatisation–headspace GC–MS system, the formation of ethyl methane sulfonate can be monitored in different reaction mixtures under different reaction conditions, including temperature, water content and pH. Excellent linearity, repeatability and robustness were obtained, allowing the system to be used in kinetic studies. 相似文献
26.
AIM: The psychometric properties of the Brief Psychiatric Rating Scale, the Beck Anxiety Inventory (BAI), and the Beck Depression Inventory (BDI) were tested in a sample of 134 patients with a substance use disorder and a non-substance related psychiatric disorder in a special inpatient dual diagnosis treatment unit. METHODS: Subjects were assessed at baseline. At discharge on average 6 months post-intake, 78% of patients were re-assessed using the same instruments. All instruments were tested in (1) their ability to discriminate patients with different diagnoses at baseline and follow-up using comparison of area under the curves, and (2) their temporal stability. Moderator regression was used to test whether thought disorder at baseline had any effect on the test-retest rank-order stability of other instruments. FINDINGS: The BPRS Thought Disorder scale was able to discriminate between patients with and without schizophrenia spectrum diagnoses, and the BDI was able to discriminate between patients with and without mood disorders and schizoaffective disorders at intake to treatment, and each instrument was significantly better than the other at discriminating relevant diagnostic groups. Discriminant correlations between the BDI and the BAI were high and statistically significant. Moderator regression analyses showed no indication that any of the scales were less stable at higher levels of thought disorder. CONCLUSIONS: It is concluded that dual diagnosis patients can be reliably assessed for symptoms using the BDI and some subscales of the BPRS. 相似文献
27.
Jaewoo Park Jinkyeong Park Yoon Suk Lee Kwangrok Jung In Ho Jung Jong-Chan Lee Jin-Hyeok Hwang Jaihwan Kim 《Hepatobiliary & pancreatic diseases international : HBPD INT》2023,22(3):294-301
Background: Pancreatic cysts are common. However, most studies are based on data collected from individual centers. The present study aimed to evaluate the changes of management patterns for pancreatic cystic lesions(PCLs) by analyzing large epidemiologic data. Methods: Between January 2007 and December 2018, information regarding pancreatic cystic lesions was acquired from the nationwide Health Insurance Review and Assessment Service database in Korea. Results: The final number of patients with... 相似文献
28.
29.
A case of well-differentiated minute hepatocellular carcinoma with extrahepatic metastasis 总被引:1,自引:0,他引:1
SOO RYANG KIM YOSHITAKE HAYASHI TOSHIYUKI MATSUOKA SOK YONG PARK SHIGEYUKI SHINTANI KAZUNORI SASAKI JUN ASANO JUNG HYO KIM KE IH KIM SUSUMU IMOTO HIROSHI ITOH MASATOSHI KUDO 《Journal of gastroenterology and hepatology》1998,13(9):892-896
A rare case of well-differentiated minute hepatocellular carcinoma (HCC) metastasizing to distant sites in a 77-year-old man with hepatitis C virus (HCV)-related cirrhosis is presented. Ultrasonography (US) disclosed a 9 mm hypoechoic lesion in segment seven (S7) of the liver, although computed tomography (CT), magnetic resonance imaging (MRI) and angiography did not reveal any space-occupying lesion. Ultrasound-guided biopsy showed the histological features of well-differentiated HCC. A plain film of the abdomen and CT revealed osteolytic changes in the sacrum and the lumbar vertebra. Ultrasound-guided biopsy of the sacrum revealed well-to-moderately differentiated HCC metastasizing from the liver. Percutaneous ethanol injection therapy (PEIT) effected complete response and completely eliminated the abnormal findings on US. Three months after PEIT, metastasis to the thoracic vertebra was revealed by CT, despite negative α-fetoprotein-mRNA in serum. This is the first report describing a well-differentiated HCC with metastatic potential. Further studies may provide insights into metastasis of well-differentiated HCC. 相似文献
30.
Theodore Krupin John C. Grove Stephen M. Gugenheim Charles J. Oestrich Steven M. Podos Bernard Becker 《Experimental eye research》1978,27(2):129-134
Calcium administration into the third ventricle of rabbits resulted in a dose-dependent elevation of intraocular pressure (IOP) and reduction in deep body temperature. These responses were not inhibited by pretreatment with atropine, phentolamine, propanolol or indomethacin. Pretreatment with agents which reduce aqueous humor production, acetazolamide and non-anesthetic doses of phenobarbital, prevented the elevation of IOP but not the induced hypothermia. Imidazole, an agent which alters calcium kinetics, blocked the hypothermia response but not the IOP elevation. 相似文献