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991.
Sugano M Shintani Y Kobayashi K Sakakibara N Isomura I Morita A 《The Journal of dermatology》2006,33(12):887-891
Discoid lupus erythematosus (DLE), a cutaneous form of lupus erythematosus, is characterized as atrophic and scaly erythema and the lesions are often refractory to a wide range of topical or systemic therapies. Herein, we present four cases of DLE that were successfully treated with topical tacrolimus. Tacrolimus ointment (0.1%) was applied to DLE lesions twice daily and the erythematous plaques readily diminished after 4-8 weeks. Adverse effects, such as burning sensation or irritations, were not observed. These results indicate that topical tacrolimus might be an effective and alternative treatment to control DLE. 相似文献
992.
993.
Namba F Kitajima H Tabata A Nakayama M Suehara N Matsunami K Yanagihara K Nishihara M Morita A Yamada M Kimoto A Hirano S Sekiguchi K Fujimura M Yanagihara I 《Pediatric research》2006,60(6):699-704
Intrauterine infection is associated with chorioamnionitis (CAM), which can lead to preterm delivery. We previously reported that the levels of IgM and the incidence of CAM were elevated in preterm infants with neonatal pulmonary emphysema. The pathogen and target of this IgM remain unclear. By using Western blot and amino acid sequences, we have determined one of the target proteins: annexin A2. Immunohistochemical analysis showed that annexin A2 was expressed at fetal chorion and amnion membranes. Among very low birth weight (VLBW) infants with hyper-IgM (> or = 30 mg/dL), 58.8% showed a high titer against annexin A2 (more than x 16), which accounted for about 20%-40% of the total IgM. Anti-annexin A2 IgM antibody inhibited plasmin generation. Furthermore, the median of anti-annexin A2 IgM titer from preterm infants who were delivered with high-grade (grade III) CAM was significantly higher than those from preterm infants without CAM (p = 0.011) and with low-grade CAM (grade I and II) (p = 0.010). Here, we indicate the fetal autoimmunoreactivity against the fetomaternal interface in preterm infants. 相似文献
994.
Tatsuya Nakamura Chihiro Shimizu Mayumi Kasahara Kazuyuki Okuda Chiyo Nakata Hiroko Fujimoto Hiroe Okura Masaru Komatsu Kouichi Shimakawa Noriyuki Sueyoshi Toshiro Ura Kaori Satoh Masahiro Toyokawa Yasunao Wada Tamaki Orita Tomomi Kofuku Katsutoshi Yamasaki Masako Sakamoto Hisaaki Nishio Shohiro Kinoshita Hakuo Takahashi 《Journal of infection and chemotherapy》2009,15(1):13-17
Extended-spectrum β-lactamase (ESBL)-producing bacteria are known to be resistant to penicillins, cephalosporins, and monobactams
because of their substrate specificity, and these bacteria are sensitive only to a narrow range of antimicrobial agents. The
present study was undertaken to evaluate the efficacy of carbapenems and the new quinolones against ESBL-producing Escherichia coli, using a Monte Carlo simulation based on the pharmacokinetic/pharmacodynamic (PK/PD) theory. The time above MIC (TAM, %)
served as the PK/PD parameter for carbapenems, with the target level set at 40%. The AUC/MIC served as the PK/PD parameter
for the new quinolones, with the target level set at more than 125. In the analysis of drug sensitivity, the MIC50 of all
carbapenems other than imipenem was low (0.03 μg/ml), while the MIC50 of the new quinolones was higher (1–2 μg/ml). The probability
of achieving the PK/PD target with carba penems after two doses at the usual dose level, as determined by the Monte Carlo
simulation, was high for each of the carbapenems tested (99.0% for biapenem, 99.60% for meropenem, and 95.03% for doripenem),
except for imipenem. Among the new quinolones, the highest probability of achieving the PK/PD target was obtained with pazufloxacin
(42.90%). Thus, the results of the present study have revealed that carbapenems are effective at the regular dose and can
be used as the first-choice antibiotics for ESBL-producing E. coli because the resistance ratios for carbapenems are low compared to those of the new quinolones. 相似文献
995.
Koichiro Shinozaki Shigeto Oda Tomohito Sadahiro Masataka Nakamura Yo Hirayama Ryuzo Abe Yoshihisa Tateishi Noriyuki Hattori Tadanaga Shimada Hiroyuki Hirasawa 《Critical care (London, England)》2009,13(4):R121-12
Introduction
Neurological prognostic factors after cardiopulmonary resuscitation (CPR) in patients with cardiac arrest (CA) as early and accurately as possible are urgently needed to determine therapeutic strategies after successful CPR. In particular, serum levels of protein neuron-specific enolase (NSE) and S-100B are considered promising candidates for neurological predictors, and many investigations on the clinical usefulness of these markers have been published. However, the design adopted varied from study to study, making a systematic literature review extremely difficult. The present review focuses on the following three respects for the study design: definitions of outcome, value of specificity and time points of blood sampling. 相似文献996.
Background Benign metastasizing leiomyoma (BML) is a rare disease most often located in the lungs of women with a history of surgery
for benign leiomyoma of the uterus. Optimum therapy for BML, has not been established. We report here an additional case of
BML in the lung that was successfully treated with surgical castration followed by hormonal therapy with anastrozole, an aromatase
inhibitor.
Case A 46-year-old primigravid Japanese woman was admitted to our hospital for investigation of multiple pulmonary nodules found
on a routine chest X-ray. At the age of 36, she had undergone myomectomy for uterine myomas. Upon gynecological examination,
her uterus, was enlarged to the size of a child’s head. Abdominal total hysterectomy, bilateral salpingo-oophorectomy, and
thracoscopic biopsy of pulmonary nodules were performed. Histologically, the lung nodules were diagnosed as BML. Subsequently
oral anastrozole was started. The patient is alive and the size of the pulmonary nodules was stable, 15 months following the
surgery.
Conclusion In addition to castration by bilateral oophorectomy or gonadotropin-releasing hormone agonist, the use of aromatase inhibitor
is one of the treatment options for the further suppression of peripheral estrogen production in these patients. 相似文献
997.
Soleymani Majd H Turner SA Choji K Lwin K B-Lynch C 《Archives of gynecology and obstetrics》2009,280(5):725-727
A 36-year-old woman presented unwell, with abdominal pain. A pelvic mass was found and being investigated but when she deteriorated
and became peritonitic. An emergency laparotomy was performed and she required a pelvic clearance for a Stage IIB ovarian
tumour, later confirmed as a yolk sac tumour. Accurate staging and tumour-reductive surgery strongly affects the prognosis
of yolk sac tumours. Thus ability to perform a meticulous surgical clearance may well positively impact on the outcome for
these young patients. This case describes the challenges that generalists will be faced with when highly suspicious cancer
patients present as an emergency. 相似文献
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